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1.发明公开METHOD AND DEVICES FOR X-RAY CRYSTALLOGRAPHY, IN PARTICULAR WITH MICROCRYSTALS OF BIOLOGICAL MACROMOLECULES 审中-公开方法和X射线晶体学设备，尤其是微晶生物大分子
公开(公告)号：EP3102930A1
公开(公告)日：2016-12-14
申请号：EP15702375.5
申请日：2015-02-03
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Arizona Board of Regents acting for and on behalf of Arizona State University
发明人： DOAK, Robert Bruce , SHOEMAN, Robert , BOTHA, Sabine , SCHLICHTING, Ilme , BARENDS, Thomas R.M. , NASS, Karol
IPC分类号： G01N23/20
摘要： A method of X-ray crystallography for investigating microscopic crystals, in particular microscopic crystals of biological macromolecules, comprises the steps of extruding a sample stream (1) with an injector nozzle device (100), wherein the sample stream (1) comprises a viscous liquid with microscopic crystals embedded therein, providing an X-ray beam (2) with a synchrotron source device (210) and irradiating the sample stream (1) with the X-ray beam (2), and collecting diffraction image data created by diffraction of the X-ray beam (2) by the microscopic crystals with a series of X-ray exposures of the sample stream (1). Furthermore, an injector nozzle device (100) and an X-ray crystallography apparatus (200) for X-ray crystallography investigations of microscopic crystals are described.
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公开(公告)号：EP2162736A1
公开(公告)日：2010-03-17
申请号：EP07840332.6
申请日：2007-06-29
申请人： Arizona Board of Regents, acting for and on behalf of Arizona State University , Millipore Corporation
IPC分类号： G01N27/42
CPC分类号： G01N27/48
摘要： A systems and apparatus for measuring non-electroactive materials in liquids using electrochemical detection. A first electrical activity of a electroactive material is detected in absence of a target non-electroactive material (Step 120). A second electrical activity of the electroactive material is detected in presence of the target non-electroactive material (Step 130). A difference between the first and second electrical activities is obtained, and based on the obtained difference, a concentration of the target non-electroactive material is identified (Step 140).
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3.发明公开REGULATED SYNTHESIS OF ANTIGEN AND/OR REGULATED ATTENTUATION TO ENHANCE VACCINE IMMUNOGENICS AND/OR SAFETY 审中-公开监管抗原合成和/或调节衰减，以提高疫苗的免疫原性和/或HEALTHANDSAFETY
公开(公告)号：EP2150616A2
公开(公告)日：2010-02-10
申请号：EP08827622.5
申请日：2008-05-09
申请人： Arizona Board of Regents, acting for and on behalf of Arizona State University , Washington University
发明人： CURTISS, III, Roy , WANG, Shifeng , WANDA, Soo-young , KONG, Wei
IPC分类号： C12N15/00
CPC分类号： C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
摘要： The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
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4.发明公开
公开(公告)号：EP2109909A1
公开(公告)日：2009-10-21
申请号：EP07869765.3
申请日：2007-12-21
发明人： FRIESEN, Cody A. , HAYES, Joel R.
CPC分类号： H01M8/04089 , H01M4/8605 , H01M8/04186 , H01M8/08 , H01M8/22 , H01M8/2455 , H01M8/247
摘要： The present invention relates to a fuel cell with a gap for transport flow of an electrolyte containing charge carrying ions from either a fuel or an oxidizer between anode and a cathode.
摘要翻译： 本发明涉及具有用于输送电流的间隙的燃料电池，所述电解质含有从阳极和阴极之间的燃料或氧化剂中携带离子的电荷。
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5.发明公开
公开(公告)号：EP1994181A2
公开(公告)日：2008-11-26
申请号：EP07757589.2
申请日：2007-02-27
发明人： JOHNSTON, Stephen, A. , LAKE, Doug
CPC分类号： C07K19/00 , A61K39/0011 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , G01N33/5011 , G01N33/5047
摘要： Disclosed are compositions relating to novopeptides identified by the presence of frameshift mutations in tumor genes previously not identified as being oncogenic. The disclosed peptides can be used in the disclosed methods for the treatment of cancer.
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公开(公告)号：EP1720552A2
公开(公告)日：2006-11-15
申请号：EP05724535.9
申请日：2005-03-04
申请人： Arizona Board of Regents, acting for and on behalf of Arizona State University , SUN HEALTH RESEARCH INSTITUTE
发明人： CHANG, Yung , LORTON, Dianne , LUBAHN, Cheri , PETTIT, George, R. , WILSON, David , ANANIEVA, Olga
IPC分类号： A61K31/4741 , A61K31/675 , A61P1/00 , A61P1/02 , A61P9/10 , A61P11/06 , A61P11/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P29/00 , A61P37/02
CPC分类号： A61K31/4741 , A61K31/675
摘要： The present invention provides methods for treating inflammatory conditions, rheumatoid diseases, autoimmune conditions, and conditions associated with bone loss, comprising administering to a subject with an inflammatory condition an amount effective to treat the condition of a compound selected from the group consisting of narcistatin, pancratistatin, pancratistatin-7' phosphate and pancratistatin-3',4' cyclic phosphate, or pharmaceutically acceptable salts thereof.
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7.发明公开MOLECULAR SIGNATURE AND ASSAY FOR FLUOROQUINOLINE RESISTANCE IN BACILLUS ANTHRACIS 审中-公开芽孢杆菌的分子标记和荧光醌抗性检测
公开(公告)号：EP1581650A3
公开(公告)日：2005-12-28
申请号：EP03816737.5
申请日：2003-10-14
申请人： Arizona Board of Regents acting for and on behalf of Arizona State University (ABR/NAU) , Keim, Paul S. , Pearson, Talima , Price, Lance , Busch, Joseph D.
IPC分类号： C12Q1/00
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公开(公告)号：EP2162736B1
公开(公告)日：2018-12-26
申请号：EP07840332.6
申请日：2007-06-29
申请人： Arizona Board of Regents, acting for and on behalf of Arizona State University , EMD Millipore Corporation
CPC分类号： G01N27/48
摘要： A systems and apparatus for measuring non-electroactive materials in liquids using electrochemical detection. A first electrical activity of a electroactive material is detected in absence of a target non-electroactive material (Step 120). A second electrical activity of the electroactive material is detected in presence of the target non-electroactive material (Step 130). A difference between the first and second electrical activities is obtained, and based on the obtained difference, a concentration of the target non-electroactive material is identified (Step 140).
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公开(公告)号：EP2430698B1
公开(公告)日：2016-07-06
申请号：EP10719193.4
申请日：2010-05-10
发明人： FRIESEN, Cody A. , BUTTRY, Daniel
CPC分类号： H01M12/08 , H01M12/06 , H01M2300/0025 , H01M2300/0045 , Y02E60/128
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公开(公告)号：EP2765991A1
公开(公告)日：2014-08-20
申请号：EP12840669.1
申请日：2012-10-12
CPC分类号： A61K38/14 , A61K9/0024 , A61K9/06 , A61K47/32 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2400/06 , A61L2430/24
摘要： A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.
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