公开(公告)号：EP2714919A4

公开(公告)日：2015-02-25

申请号：EP12789354

申请日：2012-05-25

申请人： UNIV CINCINNATI ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： CLARK JOSEPH F ,  PYNE-GEITHMAN GAIL ,  KUROSAWA YUKO ,  ZHANG KEJIAN ,  ZHANG WENYING ,  KEDDACHE MEHDI

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/156 ,  C12Q2531/113 ,  C12Q2537/143

公开(公告)号：EP2376656A4

公开(公告)日：2012-05-16

申请号：EP09830999

申请日：2009-12-01

申请人： CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： ROTHENBERG MARC ,  CALDWELL JULIE

IPC分类号： C12Q1/68 ,  C12N15/12

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

公开(公告)号：EP2819993A4

公开(公告)日：2016-01-20

申请号：EP13755719

申请日：2013-03-01

申请人： UNIV CINCINNATI ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： MERINO EDWARD J ,  MULLOY JAMES C ,  LI GUORUI ,  BELL-HORWATH TIFFANY

IPC分类号： C07C229/00 ,  A01N43/40 ,  A61K31/138 ,  A61K31/145 ,  A61K31/167 ,  A61K31/196 ,  A61K31/215 ,  A61K31/216 ,  A61K31/451 ,  A61K45/06 ,  C07C217/20 ,  C07C217/84 ,  C07C233/25 ,  C07C237/04 ,  C07C237/08 ,  C07C273/00 ,  C07C323/25 ,  C07D295/096

CPC分类号： C07C217/20 ,  A61K31/138 ,  A61K31/145 ,  A61K31/167 ,  A61K31/196 ,  A61K31/215 ,  A61K31/216 ,  A61K31/451 ,  A61K45/06 ,  C07C217/84 ,  C07C229/42 ,  C07C233/25 ,  C07C237/04 ,  C07C237/08 ,  C07C321/28 ,  C07C323/25 ,  C07D295/096 ,  A61K2300/00

摘要： Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

摘要翻译： 提供根据下式I的化合物：式I化合物在活性氧（ROS）存在下活化，因此是与升高的ROS相关的癌症的选择性抗癌治疗剂。 还提供了用于治疗与增加的ROS相关的癌症的方法和药物组合物。

公开(公告)号：EP2785872A4

公开(公告)日：2015-12-09

申请号：EP12853542

申请日：2012-12-03

申请人： UNIV OHIO STATE ,  GOVERNMENT OF THE U S A AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： FISHEL RICHARD ,  CROCE CARLO M ,  KOPELOVICH LEVY ,  ARONOW BRUCE ,  MARTIN-LOPEZ JUANA

IPC分类号： C12Q1/68 ,  A61K31/60 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/192 ,  A61K31/616 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/20 ,  G06F19/706 ,  G16H50/30 ,  Y02A90/26

摘要： Described herein are methods of preventing cancer, treating cancer, inhibiting tumor growth, predicting patient outcomes, optimizing dosage, and monitoring the efficacy of treatment. In particular, certain microRNAs and messenger RNAs are useful indicators of response to NSAID chemoprevention and therapy of patients having Lynch syndrome or hereditary non-polyposis colorectal cancer.

公开(公告)号：EP2425356A4

公开(公告)日：2014-06-25

申请号：EP10770196

申请日：2010-04-27

申请人： CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： PESTIAN JOHN ,  GLAUSER TRACY A ,  ARONOW BRUCE

IPC分类号： G06F17/18 ,  G06F19/00

CPC分类号： G16H50/20 ,  G16H50/30

摘要： A method for assessing a neuropsychiatric condition (such as, but not limited to, a risk that a subject may attempt to commit suicide or repeat an attempt to commit suicide, a risk that terminally ill patient is not being cared-for or treated according to the patient's true wishes, a risk that a subject may perform or repeat a criminal act and/or a harmful act, a risk of the subject having a psychiatric illness, and/or a risk of a subject feigning a psychiatric illness) may include a plurality of steps. A step may include receiving biomarker data associated from an analysis of the subject's biological sample and a step of receiving thought-marker data obtained pertaining to one or more of the subject's recorded thoughts, spoken words, transcribed speech, and writings. A step may include generating a biomarker score associated with the neuropsychiatric condition from the biomarker data. A step may include generating a thought-marker score associated with the neuropsychiatric condition from the thought-marker data. And a step may involve calculating a neuropsychiatric condition score based, at least in part, upon the biomarker score and the thought-marker score. Such method may be operating from one or more memory devices including computer-readable instructions configured to instruct a computerized system to perform the method, and the method may be operating on a computerized system including one or more computer servers (or other available devices) accessible over a computer network such as the Internet or over some other data network.

公开(公告)号：EP2914279A4

公开(公告)日：2016-07-06

申请号：EP13851855

申请日：2013-11-01

申请人： UNIV WASHINGTON CT COMMERCIALI ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： DUFFIELD JEREMY ,  REN SHUYU ,  HEGDE RASHMI

IPC分类号： A61K38/17

CPC分类号： C07K14/4703 ,  A61K38/1709

摘要： The present disclosure provides molecules, compositions and methods for treating scarring in organs. The molecules, compositions and methods treat scarring by modulating the WNT, platelet-derived growth factor receptor (PDGFR), transforming growth factor-beta (TGF3) and/or connective-tissue growth factor (CTGF) signaling pathways.

公开(公告)号：EP2814494A4

公开(公告)日：2016-05-04

申请号：EP13749793

申请日：2013-02-13

申请人： CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： ZHENG YI ,  JAGTAP PRAKASH ,  BOSCO EMILY E ,  MELLER JAROSLAW ,  FILIPPI MARIE-DOMINIQUE

IPC分类号： A61K31/47 ,  A61P11/00

CPC分类号： C07D498/04 ,  A61K31/473 ,  A61K31/4738 ,  A61K31/5365 ,  A61K31/5377 ,  C07D215/06 ,  C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D221/12 ,  C07D221/16 ,  C07D401/04 ,  C07D409/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/052

摘要： Inhibitors of p67phox protein are provided herein, as well as pharmaceutical compositions and methods recited thereto.

公开(公告)号：EP2408466A4

公开(公告)日：2013-08-28

申请号：EP10754107

申请日：2010-03-18

申请人： BRIGHAM & WOMENS HOSPITAL ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： DUFFIELD JEREMY ,  LANG RICHARD A

IPC分类号： A61K38/16 ,  A61K39/395 ,  A61P1/00 ,  A61P9/00 ,  A61P21/00

CPC分类号： A61K38/16 ,  G01N33/6872 ,  G01N33/6893

公开(公告)号：EP2404173A4

公开(公告)日：2012-11-14

申请号：EP10749439

申请日：2010-03-08

申请人： CINCINNATI CHILDREN S HOSPITAL MEDICAL CT ,  GEN HOSPITAL CORP ,  INST NAC DE CIENCIAS MEDICAS Y NUTRICION

发明人： MORROW ARDYTHE L ,  NEWBURG DAVID S ,  RUIZ-PALACIOS GUILLERMO M

IPC分类号： G01N33/53 ,  G01N33/558

CPC分类号： G01N33/558 ,  G01N33/5308 ,  G01N2333/42 ,  G01N2333/4724 ,  G01N2400/12

公开(公告)号：EP2418961A4

公开(公告)日：2012-09-12

申请号：EP10764968

申请日：2010-04-12

申请人： INST NAC DE CIENCIAS MEDICAS Y NUTRICION ,  GEN HOSPITAL CORP DBA ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： NEWBURG DAVID S ,  RUIZ-PALACIOS GUILLERMO M ,  MORROW ARDYTHE L

IPC分类号： A23C9/12 ,  A01N43/04 ,  A23C9/20 ,  A23K1/16 ,  A61K31/70 ,  A61K31/702 ,  A61K31/7028 ,  A61K31/715

CPC分类号： A61K31/70 ,  A23C9/206 ,  A23K20/163 ,  A23K50/10 ,  A23K50/30 ,  A23K50/40 ,  A23K50/50 ,  A23K50/75 ,  A61K31/702 ,  A61K31/7028 ,  A61K31/715

摘要： Animal food composition or veterinary pharmaceutical composition containing one or more oligosaccharides derived from milk, or a glycoconjugate including the oligosaccharide(s). Also disclosed are uses thereof for treating infected animals.

摘要翻译： 动物食物组合物或兽用药物组合物包含衍生自牛奶的一种或多种寡糖，或糖复合物包括寡糖。 所以光盘游离缺失是其治疗感染动物的用途。