公开(公告)号：EP2346455A4

公开(公告)日：2012-08-15

申请号：EP09816782

申请日：2009-09-23

申请人： CYTYC CORP

发明人： VIRAY VICTOR E ,  CALLAGHAN DAVID

IPC分类号： A61F6/06

CPC分类号： A61F6/225 ,  A61M25/0136 ,  A61M37/0069

公开(公告)号：EP1573041A4

公开(公告)日：2006-05-31

申请号：EP03773198

申请日：2003-10-07

申请人： CYTYC CORP

发明人： COHENFORD MENASHI A ,  LENTRICHIA BRIAN B

IPC分类号： C07K14/025 ,  C12Q1/68 ,  C12Q1/70 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C12Q1/6888 ,  C07K14/005 ,  C12N2710/20022 ,  C12Q1/708 ,  C12Q2600/156

摘要： Materials and methods for detection and typing of HPV infection using PNA probes, including methods for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively amplify only high-risk types of HPV. Novel primer sequences are also provided.

公开(公告)号：EP1179184A4

公开(公告)日：2004-04-21

申请号：EP00939309

申请日：2000-05-17

申请人： CYTYC CORP

发明人： HUNG DAVID T

IPC分类号： A61B10/00 ,  A61K31/00 ,  A61K31/138 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/4535 ,  A61K31/566 ,  A61M3/02 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48 ,  C12Q1/533 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/02 ,  C07K1/00

CPC分类号： G01N33/57415 ,  A61B10/0041 ,  A61K31/00 ,  A61K31/138 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/4535 ,  A61K31/566 ,  A61M3/0262 ,  A61M3/0279 ,  A61M2210/1007 ,  A61K2300/00

摘要： Methods and systems for identifying material from a breast duct using one or more markers that can be identified in ductal fluid retrieved from the breast are provided.

公开(公告)号：EP1608392A4

公开(公告)日：2007-09-05

申请号：EP04749464

申请日：2004-03-26

申请人： CYTYC CORP

发明人： LAPEN DANIEL ,  SOULE NORMAN ,  LIM SOMTHOUK

IPC分类号： A61K38/00 ,  G01N1/30

CPC分类号： G01N1/30

摘要： A method for treating a biological sample with a Papanicolaou staining process is provided. The method comprises incorporating a detergent treatment into the staining process at any of various steps. The method has been found to advantageously reduce the number of artifacts produced during Papanicolaou staining. Also provided is a sample stained by such a process.

公开(公告)号：EP0998330A4

公开(公告)日：2006-11-15

申请号：EP98931470

申请日：1998-06-22

申请人： CYTYC CORP

发明人： WILLIAMS JEFFERY A ,  PORTER CHRISTOPHER H ,  WILLIAMSON JEFFREY F ,  DEMPSEY JAMES F ,  PATRICK TIMOTHY J ,  STUBBS JAMES B

IPC分类号： A61M25/00 ,  A61N5/10 ,  A61M36/04

CPC分类号： A61N5/1015 ,  A61N2005/1021

摘要： An instrument (10) for use in brachy-therapy comprises a concentric arrangement of inner and outer distensible, spherical chambers (30, 34) disposed near the proximal end of a catheter body (12) where one of the chambers (30, 34) is made to contain a radioactive material with the other chamber (30, 34) containing a radiation absorptive material, the apparatus (10) functioning to provide a more uniform absorbed dose profile in tissue surrounding a cavity created by the removal of a tumor. An alternative embodiment includes non-spherical inner and outer chambers whose respective walls are spaced equidistant over the entire surfaces thereof.

公开(公告)号：EP1495301A4

公开(公告)日：2005-04-13

申请号：EP99967699

申请日：1999-12-27

申请人： CYTYC CORP

发明人： HUNG DAVID ,  KEN CHRISTOPHER G M ,  HE XUANMIN ,  OLSEN PHILIP M ,  NIKOLCHEV JULIAN ,  O'LEARY SHAWN ,  SAYAVONG PAM

IPC分类号： C12M1/26 ,  A61B10/00 ,  A61M3/02 ,  C12M1/28 ,  C12N5/06 ,  G01N1/00

CPC分类号： A61M3/0262 ,  A61B10/0041 ,  A61B10/0045 ,  A61M3/0279 ,  A61M2210/1007

摘要： The invention provides methods, devices and systems for collecting breast ductile fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductile access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for identification of breast percancer or cancer in patient.

公开(公告)号：EP1165160A4

公开(公告)日：2004-08-11

申请号：EP00913661

申请日：2000-02-29

申请人： CYTYC CORP

发明人： HUNG DAVID

IPC分类号： A61M37/00 ,  A61B10/00 ,  A61M1/00 ,  A61M3/02 ,  A61M3/00

CPC分类号： A61M3/0262 ,  A61B10/0041 ,  A61B10/0045 ,  A61M3/0279 ,  A61M2210/1007

摘要： Apparatus, methods and kits for simultaneous delivery of a fluid or other substance to two or more breast milk ducts are provided. The fluid can be delivered for a variety of purposes including lavage of the ducts and administering an agent for therapeutic, prophylactic, or diagnostic purposes.

公开(公告)号：EP1668338A4

公开(公告)日：2008-11-19

申请号：EP04785004

申请日：2004-09-24

申请人： CYTYC CORP

发明人： KLAUTKY TRUDEE ,  LAPEN DANIEL C

IPC分类号： A61B10/00 ,  G01N20060101 ,  G01N1/31 ,  G01N33/48 ,  G01N33/52 ,  G01N35/00

CPC分类号： G01N1/312 ,  G01N1/38 ,  G01N33/52 ,  G01N35/00594 ,  G01N35/00603 ,  G01N2035/00841 ,  G01N2035/00861 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/2575

摘要： An automated method for classifying a cytological sample is provided. The method comprises interrogating the sample with one or more wavelengths of light to obtain a result, and then attaching one or more designators to the sample based on whether the result meets a given criterion. The method allows for rapid feedback on the characteristics of the sample, permitting automated designation of the sample as positive for a given characteristic, and allowing for immediate remedial actions if the sample fails to meet the criterion.

公开(公告)号：EP1644525A4

公开(公告)日：2008-11-05

申请号：EP04756924

申请日：2004-07-09

申请人： CYTYC CORP

发明人： LINDER JAMES ,  COHENFORD MICHAEL ,  COFFMAN ERIN ,  LENTRICHIA BRIAN B

IPC分类号： C12Q1/68 ,  C12Q20060101 ,  C12Q1/70

CPC分类号： C12Q1/6881 ,  C12Q1/6841 ,  C12Q1/6888 ,  C12Q1/708 ,  C12Q2525/107

摘要： This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target of interest in the sample. In one aspect, a method is provided that comprises contacting a sample suspected of containing a target with a detectable sensor molecule known to bind to such target in an alcoholic preservative solution. The method may be performed in multiplex form to permit simultaneous analysis of a plurality of targets. Methods for identifying a sensor capable of binding to a desired target in an alcoholic preservative solution are also provided. An alcoholic preservative solution comprising one or more such detectable sensors is also provided. Also provided is a sample comprising a bound sensor provided by such a process. Also provided are kits useful for such methods.

公开(公告)号：EP1492570A4

公开(公告)日：2007-06-27

申请号：EP03723752

申请日：2003-03-17

申请人： CYTYC CORP

发明人： HUNG DAVID

IPC分类号： G01T1/161 ,  A61K48/00 ,  A61K49/00 ,  A61K51/04 ,  A61M25/00 ,  A61M39/00

CPC分类号： A61K51/0491 ,  A61K48/00

摘要： The present invention relates to an apparatus and method for administering diagnostic and therapeutic agents into a breast duct. A thymidine kinase vector may be administered into a breast duct in conjunction with an acycloguanidine compound for enhanced imaging on PET scanning of the breast to detect breast lesions. The thymidine kinase phosphoraylates the acycloguanidine compound to enhance visibility of lesions on PET scan. An acyclic nucleoside compound may be administered into the breast duct to form phosphorylated adducts that phosphorylate DNA and kill thymidine kinase expressing cancer cells.