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    Apparatus for preparing an elongate fluid-containing member and related apparatus for removing fluid from such member
    3.
    发明公开
    Apparatus for preparing an elongate fluid-containing member and related apparatus for removing fluid from such member 失效
    用于制备含扩展构件和用于从液体，例如构件去除液体对应的设备的装置。

    公开(公告)号：EP0438626A2

    公开(公告)日：1991-07-31

    申请号：EP90111059.3

    申请日：1990-06-12

    申请人： CRYO-CELL INTERNATIONAL INC.

    发明人： Knippscheer, Hermann ,  Richard, Daniel D.

    IPC分类号： A01N1/00 ,  A61B10/00 ,  A61B17/00 ,  A61M1/00 ,  B65B51/04 ,  B65B9/12

    CPC分类号： B65B51/04 ,  A01N1/0263 ,  A61B10/0045 ,  A61B10/0096 ,  A61B17/128 ,  A61B17/32 ,  A61B17/42

    摘要： An apparatus (10) for preparing an elongate fluid-containing member (12) such as an umbilical cord comprises a housing (14) and support elements (30) in the housing for maintaining the umbilical cord in a substantially linear configuration. The support elements are generally horizontally oriented and arranged in a linear array and are pivotably mounted to the housing. A clamping device (42) in the housing applies at least four clamps or staples to the umbilical cord, while a severing device (58) divides the umbilical cord at a point between two midle staples to form at least two separate sections of the umbilical cord. A transfer mechanism in the housing automatically transfers the severed umbilical cord sections to respective receptacles (74), the transfer mechanism including a device (34) operatively connected to the support elements for tilting those elements, the transfer mechanism further including guide funnels (36) disposed in the housing below the support elements for guiding the severed sections of the umbilical cord into the receptacles. A closure assembly (150) is provided for automatically closing the receptacles upon the disposition therein of the severed sections of the umbilical cord. And a control unit (28) is operatively connected to the clamping device, the severing device, the transfer mechanism and the closure assembly for sequencing the operations thereof.

    摘要翻译： 用于制备伸长含流体元件（12）的装置（10）：如在脐带包括在所述外壳中的壳体（14）和支撑元件（30），用于在大致线性构造维护脐带。 支撑元件是基因反弹水平定向并以线性阵列布置并且可枢转地安装到壳体。 在壳体内的夹紧装置（42）适用于至少四个夹具或卡钉到脐带，而切断装置（58）将所述脐带在两个midle钉之间的点，以形成所述脐带的至少两个分开的部分 ， 在壳体中的传送机构自动地传送被切断的脐带部到respectivement插座（74），所述传送机构包括一个装置（34）可操作地连接到用于倾斜的那些元件，所述转移机构还包括导向漏斗的支撑元件（36） 布置在用于引导脐带的被切断的部分进入插座支撑元件下方的外壳。 的封闭组件（150）被设置用于在其中的脐带的被切断的部分的经配置自动关闭所述容器。 和控制单元（28）可操作地连接到所述夹持装置，所述切断装置中，传送机构和用于测序其操作的封闭组件。

    METHODS FOR CO-CULTURING CORD BLOOD DERIVED CELLS WITH MENSTRUAL STEM CELLS
    5.
    发明公开
    METHODS FOR CO-CULTURING CORD BLOOD DERIVED CELLS WITH MENSTRUAL STEM CELLS 审中-公开
    方法培养具有经期干细胞的脐血衍生细胞

    公开(公告)号：EP2212418A1

    公开(公告)日：2010-08-04

    申请号：EP08845236.2

    申请日：2008-10-31

    申请人： Cryo-Cell International, Inc. ,  Allickson, Julie G.

    发明人： ALLICKSON, Julie, G. ,  WALTON, Mercedes, A.

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0647 ,  C12N2502/137 ,  C12N2502/1388 ,  C12N2502/243

    摘要： Methods are provided for obtaining expanded human cord blood cells expressing CD34. The methods involve seeding a sufficient amount of cord blood cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord blood cells, and co-culturing the cord blood cells with the menstrual cells under culture conditions that support at least two or more population doublings of the cord blood cells. Methods are also provided for growing expanded human cord blood cells to give rise to any one of colony forming units, colony forming unit granulocyte macrophages (CFU-GM), burst forming unit erythroids (BFU-E), and colony forming unit granulocyte erythrocyte macrophage megakaryocyte (CFU- GEMM) blood lineage precursor cells. The expanded cells may express CD34, SSEA-4, and HLA-II. Compositions of the expanded cells are also provided.

    摘要翻译： 提供了用于获得表达CD34的扩增人脐带血细胞的方法。 所述方法包括在足以促进脐带血细胞扩增的共同培养条件下接种足够量的脐带血细胞和足量的月经细胞，并在支持培养条件下共培养脐带血细胞与月经细胞 至少两次或更多次脐带血细胞的群体倍增。 还提供了用于生长扩增的人脐带血细胞以产生集落形成单位，集落形成单位粒细胞巨噬细胞（CFU-GM），爆发形成单位红细胞（BFU-E）和集落形成单位粒细胞红细胞巨噬细胞 巨核细胞（CFU-GEMM）血液谱系前体细胞。 扩增的细胞可以表达CD34，SSEA-4和HLA-II。 还提供了扩展细胞的组成。

    STORAGE APPARATUS, PARTICULARLY WITH AUTOMATIC INSERTION AND RETRIEVAL
    7.
    发明公开
    STORAGE APPARATUS, PARTICULARLY WITH AUTOMATIC INSERTION AND RETRIEVAL 失效
    存储设备中，尤其是自动开启和外包

    公开(公告)号：EP1012515A2

    公开(公告)日：2000-06-28

    申请号：EP98913233.7

    申请日：1998-03-27

    申请人： Cryo-Cell International, Inc.

    发明人： VAGO, Robert, E.

    IPC分类号： F25D23/12 ,  F25D25/00 ,  F25D25/02

    CPC分类号： G01N1/42 ,  F25D25/00 ,  G01N2035/0453 ,  G01N2035/0465

    摘要： A storage unit includes a housing (72) with a storage chamber, a carrier (100) disposed inside the chamber for supporting a plurality of specimens (138) in a predetermined array, and an access port (76) on the housing (72) for enabling access to the chamber for insertion and retrieval of specimens (138) from the carrier (1009. The access port (76) includes an opening in the housing (72) and a plug member (86) removably located in the opening. The carrier (100) is provided with a seat (194) for receiving the plug member (86) during an access operation, so that the plug member (86) is located in the chamber during the access operation. A drive is operatively connected to the carrier (100) for moving the carrier (100) in the chamber to juxtapose different specimens (138) to the access port (76). An insertion and removal mechanism (142) is coupled to the housing (72) for alternately inserting and removing specimens (138) from the chamber via the access port (76) during the access operation.

    Cryogenic storage apparatus
    8.
    发明公开
    Cryogenic storage apparatus 失效
    Kryogene Lagervorrichtung。

    公开(公告)号：EP0411224A2

    公开(公告)日：1991-02-06

    申请号：EP89311300.1

    申请日：1989-11-01

    申请人： CRYO-CELL INTERNATIONAL INC. (a Delaware corporation)

    发明人： Knippscheer, Hermann ,  Richard, Daniel D.

    IPC分类号： F25D3/11 ,  B65G1/127 ,  B65G1/137

    CPC分类号： G01N1/42 ,  B65G1/127 ,  B65G1/1371 ,  F25D3/11 ,  G01N35/021

    摘要： A cryogenic storage apparatus comprises a housing (1) with an automatically operated access door (19). A holder device (4) disposed in the housing (1) supports a plurality of specimen-containing ampules (16), while a conveyor (3) moves the holder device (4), together with the plurality of ampules (16), through cooling fluid in the housing (1) along a path (103) preferably including a snaking portion (105) with vertically extending folds (109). An inverted L-shaped cooling component (18) with an opened upper side is disposed in the housing (1) for maintaining the cooling fluid at a predetermined low temperature. An extraction mechanism (50) disposed outside of the housing (1) at the access door (19) serves to remove a selectable ampule (16) positioned in the housing (1) in juxtaposition to the door (19). A tracking device automatically tracks the positions of the ampules (16) during motion thereof along the snaking path (105), while a control unit (cc1) connected to the tracking device, the drive mechanism (115), the conveyor (3) and the extraction mechanism (50) activates the conveyor (3) to move a given ampule (16) along the path (103) to the access door (19), opens the access door (19), and operates the extraction mechanism (50) to remove the given ampule (16) from the holder device (4) and out through the opened door (19).

    摘要翻译： 低温储存装置包括具有自动操作的检修门（19）的外壳（1）。 设置在壳体（1）中的保持器装置（4）支撑多个包含标本的安瓿（16），而输送机（3）与多个安瓿（16）一起移动保持装置（4），通过 壳体（1）中沿着优选地包括具有垂直延伸折叠（109）的蛇形部分（105）的路径（103）的冷却流体。 具有敞开的上侧的倒L形冷却部件（18）设置在壳体（1）中，用于将冷却流体保持在预定的低温。 在进出门（19）处设置在壳体（1）外侧的提取机构（50）用于移除与门（19）并置的位于壳体（1）中的可选安瓿（16）。 跟踪装置在其沿着蛇形路径（105）的运动期间自动跟踪安瓿（16）的位置，而连接到跟踪装置的控制单元（cc1），驱动机构（115），输送机（3）和 提取机构（50）启动输送机（3）以将给定的安瓿（16）沿着路径（103）移动到检修门（19），打开检修门（19）并操作提取机构（50） 从保持装置（4）中取出给定的安瓿（16），并通过打开的门（19）离开。