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    Sensing, interrogating, storing, telemetering and responding medical implants
    1.
    发明公开
    Sensing, interrogating, storing, telemetering and responding medical implants 审中-公开
    Medinzinisches植入物接触，数据存储和遥测信号和用于递送治疗

    公开(公告)号：EP1847217A2

    公开(公告)日：2007-10-24

    申请号：EP07000766.1

    申请日：2000-09-15

    Applicant: ENDOLUMINAL THERAPEUTICS, INC.

    Inventor： Slepian, Marvin J.

    IPC: A61B5/0205 ,  A61B5/00

    CPC classification number: A61B5/14539 ,  A61B5/0031 ,  A61B5/02007 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/145

    Abstract: Implants, including sensors responsive to pressure, fluid flow, concentration of analytes, pH and other variables, including a feedback loop and means for modifying the implant after placement in a patient in response to measurements made using the sensors, have been developed. Feedback from the sensor(s) signal changes that may be required, such as expansion of the implant in the case where the vessel diameter changes over time or the implant becomes unstable or migrates. In another embodiment, the implant contains a bioactive, prophylactic, diagnostic or pH modifying agent wherein the implant is formed of a temperature or pH responsive material so that the agent is released when the temperature or pH is altered. These systems can also be used to connect a patient to a remote data storage system, such as the internet or a computer accessible through devices such as PDA (Palm Pilot systems), phone system devices, that the physician can use to interact remotely with the implant.

    Abstract translation: 植入物，包括传感器响应于压力，流体流量，分析物的浓度，pH和其它变量，包括用于响应于使用传感器进行的测量修改放置后，植入物在患者中的反馈回路和手段，已被开发。 从传感器（一个或多个）信号的变化的反馈也可能需要,:诸如在随时间的血管直径变化或植入物变得不稳定或迁移的情况下的植入物的膨胀。 在另一个，本实施例的植入物包含生物活性，预防，诊断或pH调节剂worin所述植入物形成的温度下或pH响应性材料的所以没有剂释放当温度或PH值被改变。 因此，这些系统可用于向患者连接到远程数据存储系统，：诸如因特网或通过设备访问的计算机：如PDA（Palm试验系统）电话系统设备，没医生可以用来与远程交互 植入物。

    SENSING, INTERROGATING, STORING, TELEMETERING AND RESPONDING MEDICAL IMPLANTS
    2.
    发明公开
    SENSING, INTERROGATING, STORING, TELEMETERING AND RESPONDING MEDICAL IMPLANTS 有权
    医疗植入物对于触摸，数据存储和遥测

    公开(公告)号：EP1215994A1

    公开(公告)日：2002-06-26

    申请号：EP00961948.7

    申请日：2000-09-15

    Applicant: ENDOLUMINAL THERAPEUTICS, INC.

    Inventor： SLEPIAN, Marvin, J.

    IPC: A61B5/00

    CPC classification number: A61B5/02055 ,  A61B5/0031 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/145 ,  A61B5/14539

    Abstract: Implants, including sensors responsive to pressure, fluid flow, concentration of analytes, pH and other variables, including a feedback loop and means for modifying the implant after placement in a patient in response to measurements made using the sensors, have been developed. Feedback from the sensor(s) signal changes that may be required, such as expansion of the implant in the case where the vessel diameter changes over time or the implant becomes unstable or migrates. In another embodiment, the implant contains a bioactive, prophylactic, diagnostic or pH modifying agent wherein the implant is formed of a temperature or pH responsive material so that the agent is released when the temperature or pH is altered. These systems can also be used to connect a patient to a remote data storage system, such as the internet or a computer accessible through devices such as PDA (Palm Pilot systems), phone system devices, that the physician can use to interact remotely with the implant.

    CHANNELED ENDOMURAL THERAPY
    3.
    发明公开
    CHANNELED ENDOMURAL THERAPY 审中-公开
    利用渠道ENDOMURALE治疗

    公开(公告)号：EP1948043A1

    公开(公告)日：2008-07-30

    申请号：EP06825828.4

    申请日：2006-10-13

    Applicant: ENDOLUMINAL THERAPEUTICS, INC.

    Inventor： SLEPIAN, Marvin, J.

    IPC: A61B17/22 ,  A61B17/00 ,  A61B18/24 ,  A61B17/88

    CPC classification number: A61B17/3207 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/12195 ,  A61B17/22 ,  A61B18/24 ,  A61B2017/00247 ,  A61B2017/1205 ,  A61B2017/22077 ,  A61B2018/00392 ,  A61K35/545

    Abstract: Diseases, aging, trauma, environmental exposure, infection and other events or agents can alter tissue function. In one embodiment, treatment is provided by therapeutically altering tissue function. This may be by continuing normal tissue function, suppressing tissue function, or enhancing tissue function. In a preferred embodiment, this treatment is effectuated by penetrating an organ, organ component or tissue structure and placing a supplemental material in a newly created space. This space is generally referred to herein as a "privileged space", i.e. a space not otherwise present in native tissue. Supplemental materials can be deposited and secured within the zone. Supplemental materials include materials forming barriers, supports, and/or materials that deliver agents having a pharmacologic, biochemical, or physiologic effect in vivo. Suitable supplemental materials include polymeric and non-polymeric materials, pharmacologic agents, cells, tissue fragments, microorganisms, viral agents, or other reagents modifying tissue function. The supplemental material is typically in the form of a reservoir/depot, or continuous or discontinuous layer. In one embodiment, supplemental materials, and methods of use thereof, are provided for the continuous or discontinuous therapy of defined regions of an organ, organ component or tissue structure. The supplemental materials may be delivered directly to any one or more of the three zones, endoluminal (or ectomural, for solid organs), endomural, or ectoluminal, of organs, organ components, or tissue structures. The supplemental materials can include natural or synthetic polymeric materials that are biodegradable or non-biodegradable. The supplemental materials can also contain bioactive agents to effectuate a change in an organ or organ component in need thereof. For example, agents that result in a reduced/hyponormal response or an amplified/hypernormal response may be included in the supplemental materials.

    ENDOMURAL THERAPY
    5.
    发明公开
    ENDOMURAL THERAPY 审中-公开
    内分泌治疗

    公开(公告)号：EP1463438A2

    公开(公告)日：2004-10-06

    申请号：EP02704388.4

    申请日：2002-02-08

    Applicant: ENDOLUMINAL THERAPEUTICS, INC.

    Inventor： SLEPIAN, Marvin, J.

    IPC: A61B1/00

    CPC classification number: A61K9/0024 ,  A61B17/00491 ,  A61B17/3478 ,  A61B2017/00398 ,  A61B2017/00871 ,  A61M25/00 ,  A61M2025/0057 ,  A61M2025/0058

    Abstract: Methods, devices and materials for the treatment or repair, replacement, transplantation or augmentation of tissues in endomural zones specifically by open surgical, minimally invasive or percutaneous transmural or trans parenchymal application of polymeric material alone or in combination with bioactive agents or cells, have been developed. These methods and systems are useful to repair, after function, replace function or augment function of the central or endomural aspects of solid organs or tubular body structures.

    Abstract translation: 特别通过开放式手术，微创或经皮透壁或经实质应用单独或与生物活性剂或细胞组合的聚合物材料，用于治疗或修复，置换，移植或增强组织在月经带中的方法，装置和材料已经 发达。 这些方法和系统有助于修复功能后，替换实体器官或管状体结构的中心或腔内方面的功能或增强功能。

    SENSING, INTERROGATING, STORING, TELEMETERING AND RESPONDING MEDICAL IMPLANTS
    8.
    发明授权
    SENSING, INTERROGATING, STORING, TELEMETERING AND RESPONDING MEDICAL IMPLANTS 有权
    医疗植入物对于触摸，数据存储和遥测

    公开(公告)号：EP1215994B1

    公开(公告)日：2007-07-25

    申请号：EP00961948.7

    申请日：2000-09-15

    Applicant: ENDOLUMINAL THERAPEUTICS, INC.

    Inventor： SLEPIAN, Marvin, J.

    IPC: A61B5/00

    CPC classification number: A61B5/02055 ,  A61B5/0031 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/145 ,  A61B5/14539

    Abstract: Implants, including sensors responsive to pressure, fluid flow, concentration of analytes, pH and other variables, including a feedback loop and means for modifying the implant after placement in a patient in response to measurements made using the sensors, have been developed. Feedback from the sensor(s) signal changes that may be required, such as expansion of the implant in the case where the vessel diameter changes over time or the implant becomes unstable or migrates. In another embodiment, the implant contains a bioactive, prophylactic, diagnostic or pH modifying agent wherein the implant is formed of a temperature or pH responsive material so that the agent is released when the temperature or pH is altered. These systems can also be used to connect a patient to a remote data storage system, such as the internet or a computer accessible through devices such as PDA (Palm Pilot systems), phone system devices, that the physician can use to interact remotely with the implant.

    TREATMENT OF TISSUES TO REDUCE SUBSEQUENT RESPONSE TO INJURY
    9.
    发明公开
    TREATMENT OF TISSUES TO REDUCE SUBSEQUENT RESPONSE TO INJURY 失效
    组织用于业务干扰的减少所引起的应变准备

    公开(公告)号：EP0785801A1

    公开(公告)日：1997-07-30

    申请号：EP95939831.0

    申请日：1995-10-11

    Applicant: ENDOLUMINAL THERAPEUTICS, INC.

    Inventor： SLEPIAN, Marvin, J. ,  MASSIA, Stephen, P.

    IPC: C07D311 ,  A61K31 ,  A61K33 ,  A61K38 ,  A61K41 ,  A61K45 ,  A61K47 ,  A61P7 ,  A61P43

    CPC classification number: A61K41/0023

    Abstract: An exogenous stimulus is applied to tissues or cells which are at risk in a subsequent surgical procedure or other intervention which induces a response by the cells that minimizes reaction to the subsequent procedure. Stimuli can be chemical, physiological or physical. Examples include those stimuli known to induce expression of stress response proteins or heat shock proteins, especially heat shock protein 70 (hsp 70) and hsp 90, for example, exposure to heat or dilute hydrogen peroxide, or direct administration of exogenous heat shock proteins, or those stimuli which act to inhibit or reduce heat shock protein expression, for example, treatment with flavonoids. An amount effective to modulate levels of stress response proteins or reduce the endogenous response is administered, based on in vitro assays which are used to determine levels of heat shock proteins or which are experimentally determined to reduce cell proliferation, thrombus formation, and matrix deposition following subsequent exposure to a procedure. Procedures can be surgery, angioplasty, or abrasion. The method and compositions are also useful in mediating some disease processes, where the process involves undesirable migration.

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