公开(公告)号：EP2066315A1

公开(公告)日：2009-06-10

申请号：EP07820528.3

申请日：2007-09-24

申请人： GPC Biotech AG

发明人： MCKEARN, Thomas J. ,  ROZENCWEIG, Marcel

IPC分类号： A61K31/282 ,  A61K31/573 ,  A61P35/00

CPC分类号： A61K31/282 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

摘要： The instant invention relates to methods using satraplatin, packaged-pharmaceutical-products that include satraplatin and uses of satraplatin to prepare pharmaceutical compositions for the treatment of pain associated with metastatic hormone refractory prostate cancer.

公开(公告)号：EP1303303A4

公开(公告)日：2009-06-10

申请号：EP01937390

申请日：2001-05-14

申请人： GPC BIOTECH AG ,  MORPHOSYS AG

发明人： NAGY ZOLTAN ,  TESAR MICHAEL ,  THOMASSEN-WOLF ELISABETH

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/02 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N5/06 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  G01N33/53 ,  A61P37/00

CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76

摘要： The present invention relates to human peptides/proteins comprising at least one antibody-based antigen-binding domain of human composition with a binding specificity for a human MHC class II antigen, wherein binding of said peptide/protein to said antigen expressed on the surface of a cell causes or leads to modulation of the immune system. The invention further relates to nucleic acids encoding said peptides/proteins, methods for production, immunosuppression, pharmaceutical and diagnostic compositions or kits comprising the peptides/proteins and uses of the peptides/proteins.

公开(公告)号：EP1156060B1

公开(公告)日：2007-06-27

申请号：EP00110065.0

申请日：2000-05-12

申请人： GPC Biotech AG ,  MorphoSys AG

发明人： Nagy, Zoltan ,  Brunner, Christoph ,  Tesar, Michael ,  Thomassen-Wolf, Elizabeth

IPC分类号： C07K16/00 ,  C07K16/30 ,  C07K16/28 ,  C12N15/13 ,  C12N15/70 ,  C12N15/85 ,  C12N1/21 ,  C12N5/10 ,  A61K39/395 ,  G01N33/577 ,  G01N33/574 ,  G01N33/68 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

公开(公告)号：EP1721609A3

公开(公告)日：2007-01-31

申请号：EP06013237.0

申请日：2002-05-16

申请人： GPC Biotech AG

发明人： Stein-Gerlach, Matthias ,  Salassidis, Konstadinos ,  Bacher, Gerald ,  Müller, Stefan ,  Klebl, Bert ,  Marosfalvi, Jenö ,  Keri, György ,  Örfi, Laszlo ,  Varga, Zoltan

IPC分类号： A61K31/506 ,  G01N33/68 ,  C12Q1/42 ,  C12Q1/48 ,  C07K16/40 ,  C12N15/11 ,  A61P25/28 ,  C07D401/04 ,  C07D409/14 ,  C07D401/14 ,  C07D471/04

CPC分类号： C07D401/04 ,  A61K31/506 ,  A61K31/7084 ,  A61K31/7088 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04 ,  G01N2500/04

摘要： The present invention relates to pyridylpyrimidine derivatives of the general formula (I):

wherein R represents hydrogen or methyl and Z represents nitrogen containing functional groups, the use of the pyridylpyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of prion infections and prion diseases, as well as compositions containing at least one pyridylpyrimidine derivative and/or pharmaceutically acceptable salt thereof. Furthermore, the present invention is directed to methods for preventing and/or treating prion infections and prion diseases using said pyridylpyrimidine derivatives. Human cellular protein kinases, phosphatases and cellular signal transduction molecules are disclosed as targets for detecting, preventing and/or treating prion infections and diseases, especially BSE, vCJD, or CJD which can be inhibited by the inventive pyridylpyrimidine derivatives.

公开(公告)号：EP1673346A1

公开(公告)日：2006-06-28

申请号：EP04790130.1

申请日：2004-10-05

申请人： GPC Biotech AG

发明人： HERGET, Thomas

IPC分类号： C07D215/44 ,  A61K31/517

CPC分类号： C07D215/44

摘要： The present invention relates to phenyl-quinazolinyl-amine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one of these derivatives and/or pharmaceutically salts thereof, as well as the use of these derivatives for the prophylaxis and/or treatment of herpesviral induced infections, including opportunistic infections, especially for the prophylaxis and/or treatment of infections and diseases induced by HCMV.

公开(公告)号：EP1289551A1

公开(公告)日：2003-03-12

申请号：EP01935513.0

申请日：2001-05-14

申请人： GPC Biotech AG ,  MorphoSys AG

发明人： NAGY, Zoltan ,  BRUNNER, Christoph ,  TESAR, Michael ,  THOMASSEN-WOLF, Elisabeth

IPC分类号： A61K39/395 ,  A61K39/44

CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

摘要： The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.

摘要翻译： 本发明涉及导致或导致包括淋巴样肿瘤细胞在内的细胞杀伤的人肽/蛋白质。 本发明还涉及编码肽/蛋白质的核酸，用于产生肽/蛋白质的方法，用于杀死细胞的方法，药物，诊断和多价组合物以及包含肽/蛋白质的试剂盒和肽/蛋白质的用途。

公开(公告)号：EP2096107A1

公开(公告)日：2009-09-02

申请号：EP09161687.0

申请日：2004-12-23

申请人： GPC Biotech AG

发明人： Murthi, Krishna K. ,  Köstler, Roland ,  Smith, Chase ,  Brandstetter, Tilman ,  Kluge, Arthur F.

IPC分类号： C07D213/74 ,  C07D401/12 ,  A61K31/4406 ,  A61K31/4409 ,  A61P35/00

CPC分类号： C07D213/74 ,  C07D401/12

摘要： The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and arc useful in the treatment of diseases including cancer.

摘要翻译： 本发明提供方酸的衍生物，特别是3,4-二氨基 - 环丁-3-烯-1,2-二酮及其互变异构体及其异构体的衍生物，作为单一立体异构体或立体异构体的混合物，或作为药学上 其可接受的盐。 这些化合物显示抗增殖活性，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：EP1833832A1

公开(公告)日：2007-09-19

申请号：EP06847011.1

申请日：2006-01-02

申请人： GPC Biotech AG

发明人： MÜLLER, Stefan ,  SCHWAB, Wilfried ,  KLEBL, Bert ,  HAFENBRADL, Doris ,  HOPPE, Edmund ,  HORVATH, Zoltán ,  KERI, György ,  VARGA, Zoltán ,  ÖRFI, László ,  MAROSFALVI, Jenö ,  MÜLLER, Gerhard

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P7/02 ,  A61P9/00 ,  A61P11/06 ,  A61P19/10 ,  A61P15/10 ,  A61P27/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to compounds having a naphthyridine scaffold, and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these naphthyridine derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said naphthyridine compounds have been identified as inhibitors of the protein kinase ROCK2, also known as Rho-kinase, and are useful for the treatment of cancers (tumor growth and metastases), erectile dysfunction, cardiovascular diseases, hypertension, angina pectoris, cerebral ischaemia, cerebral vasospasm, myocardial ischaemia, coronary vasospasm, heart failure, myocardial hypertrophy, atherosclerosis, restenosis, spinal cord injuries, neuronal degeneration, thrombotic disorders, asthma, glaucoma, inflammation, anti-viral diseases (e.g. HIV), and osteoporosis.

公开(公告)号：EP1720540A2

公开(公告)日：2006-11-15

申请号：EP05715410.6

申请日：2005-02-18

申请人： GPC Biotech AG

发明人： CALIGIURI, Maureen ,  WOSIKOWSKI-BUTERS, Katja ,  CASAZZA, Anne Maria

IPC分类号： A61K31/282 ,  A61P35/00 ,  A61K33/24

CPC分类号： A61K45/06 ,  A61K31/282 ,  A61K31/555 ,  A61K33/24 ,  A61K2300/00

摘要： The instant invention relates to methods, pharmaceutical compositions and packaged pharmaceuticals for treating resistant or refractory tumors by administering platinum-based compounds.

公开(公告)号：EP1165832A2

公开(公告)日：2002-01-02

申请号：EP00920677.2

申请日：2000-04-07

申请人： GPC Biotech AG

发明人： LOFERER, Hannes ,  JACOBI, Alexander

IPC分类号： C12Q1/18 ,  C07K14/245 ,  C12Q1/68

CPC分类号： C07K14/245 ,  A61K38/00 ,  C12Q1/18

摘要： The present invention relates to a method for identifying an antagonist or inhibitor of the expression of a gene encoding a polypeptide essential for bacterial growth or survival as well as for an antagonist or inhibitor of said polypeptide. The invention further relates to a method for improved antagonists or inhibitors. The invention also provides an antagonist or inhibitor of the activity of said polypeptide. The invention is further related to a method for producing a therapeutic agent in a composition comprising said antagonist or inhibitor. Furthermore, the invention is related to the use of the polypeptide and the antagonist or inhibitor as well as to a method to identify a surrogate marker.