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1.发明公开AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 审中-公开氨基丙二醇衍生物，工艺用于生产药物组合物适当地使用该
公开(公告)号：EP2786982A4
公开(公告)日：2015-04-15
申请号：EP12808109
申请日：2012-07-05
发明人： HAN WEIJUAN , ZHANG HAIJING , WANG XIAOJIAN , JIN JING , LI GANG , ZHANG YI , XIAO QIONG , ZHOU WANQI , CHEN XIAOGUANG , YIN DALI
IPC分类号： C07C215/38 , A61K31/137 , A61K31/341 , A61K31/40 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/505 , A61P37/02 , A61P37/04 , A61P37/06 , C07C31/44 , C07C217/48 , C07C217/56 , C07C323/32 , C07D207/333 , C07D263/32 , C07D277/24 , C07D277/26 , C07D307/28
CPC分类号： C07D307/52 , A61K31/137 , A61K31/341 , A61K31/40 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/505 , C07C217/64 , C07C217/72 , C07C233/18 , C07C233/47 , C07C323/32 , C07C323/62 , C07C2601/02 , C07D207/333 , C07D213/38 , C07D233/64 , C07D239/26 , C07D263/32 , C07D277/24 , C07D277/26 , C07D277/28 , C07D307/38 , C07D307/42
摘要： Disclosed are immune-modulators of formula (I), the preparation method thereof, a pharmaceutical composition containing the immune-modulators, and the use of the pharmaceutical composition as a drug, especially as an immune-modulating drug. The compound can be used in immune disorders and immune suppression, and can be used in treating hypo-immunity, rejection after organ transplantation and auto-immune disease.
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2.发明公开THE USE OF POTASSIUM 2-( - HYDROXYPENTYL) BENZOATE IN THE MANUFACTURE OF MEDICAMENTS FOR PREVENTING AND/OR TREATING SENILE DEMENTIA 有权钾的2-（羟基戊基）苯甲酸酯在药物方面的制造用于预防和/或治疗AGE性痴呆
公开(公告)号：EP2332530A4
公开(公告)日：2012-02-01
申请号：EP08773142
申请日：2008-07-08
发明人： WANG XIAOLIANG , ZHAO WANHONG , YANG JINGHUA , WANG LING , LI JIANG , XU SHAOFENG , FENG NAN , MA SHIPING
CPC分类号： A61K31/192
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3.发明公开THE USE OF THE EFFECTIVE SECTION OF ALKALOIDS FROM RAMULUS MORI FOR PREPARATION OF A HYPOGLYCEMIG AGENT 审中-公开用于制备降血糖剂，从桑枝生物碱的截面的有效使用
公开(公告)号：EP2255822A4
公开(公告)日：2011-05-11
申请号：EP07800760
申请日：2007-08-22
发明人： LIU YULING , SHEN ZHUFANG , CHEN ZHEN , WANG RENYUN , XIA XUEJUN , CHEN YUETENG , LIU QUAN , SUN SUJUAN , XIE MINGZHI
IPC分类号： A61K36/605 , A61K125/00 , A61P3/10
CPC分类号： A61K36/605
摘要： The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.
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4.发明公开CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE 有权化学合成及抗肿瘤和ANTIMETASTASEWIRKUNG一个共轭双重功能
公开(公告)号：EP2612857A4
公开(公告)日：2014-07-23
申请号：EP11786102
申请日：2011-05-27
IPC分类号： C07D305/14 , A61K31/337 , A61K47/48 , A61P35/00 , A61P35/04 , A61P37/04 , C07D405/12 , C07D409/12 , C07K5/06
CPC分类号： C07K5/0215 , A61K31/337 , A61K47/54 , A61K47/542 , A61K47/65 , C07D305/14 , C07D405/12 , C07D409/12
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5.发明公开INSULIN-LIPID COMPLEX, PREPARATION METHOD THEREFOR, AND PREPARATION THEREOF 审中-公开胰岛素 - 脂质体，大肠杆菌DAFÜRUNDPRÄPARATDARAUS
公开(公告)号：EP2594281A4
公开(公告)日：2014-02-26
申请号：EP11806298
申请日：2011-07-14
发明人： LIU YULING , ZHOU CUIPING , SONG ZHIHUI , LI LIN , WANG HONGLIANG , XIA XUEJUN , WANG RENYUN , DONG WUJUN , JIN DUJIA
摘要： Provided are an insulin-lipid complex, a preparation method therefor, and a preparation therefor. The insulin-lipid complex is prepared by compounding insulin and a lipid material in organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is1:3ˆ¼1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.
摘要翻译： 提供胰岛素 - 脂质复合物及其制备方法及其制备方法。 胰岛素 - 脂质复合物通过将胰岛素和脂质物质混合在含有低沸点酸的有机溶剂体系中并干燥来制备。 胰岛素与脂质的质量比为1:3:1:20。 进一步提供胰岛素 - 脂质复合物和含有胰岛素的囊泡的油溶液。
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公开(公告)号：EP2494956A4
公开(公告)日：2013-10-23
申请号：EP10826098
申请日：2010-10-28
发明人： LIU YULING , XIA XUEJUN , GUO RUIFANG , ZHANG PENGXIAO , ZHOU CUIPING , WANG RENYUN , JIN DUJIA
IPC分类号： A61K9/107 , A61K31/337 , A61K47/28 , A61P35/00
CPC分类号： A61K31/575 , A61K9/1075 , A61K9/145 , A61K9/19 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/337 , A61K31/57 , A61K45/06 , A61K2300/00
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7.发明公开N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF 审中-公开N6-取代腺苷衍生物，N6 - 取代腺嘌呤及其用途
公开(公告)号：EP2511283A4
公开(公告)日：2013-07-03
申请号：EP09851974
申请日：2009-12-10
发明人： SHI JIANGONG , ZHANG JIANJUN , YUE ZHENGGANG , LI MIN , ZHU CHENGGEN , ZHANG YING , ZI JIACHEN , WANG YAFANG , FAN XIAONA , XU RUIMING , LIN SHENG , LI YAN , YANG YONGCHUN , SHENG LI
IPC分类号： C07H19/167 , A61K31/70 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/28 , C07D473/00
CPC分类号： C07D473/34 , C07H19/167
摘要： The present invention provides N 6 -substituted adenosine derivatives and N 6 -substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.
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8.发明公开TWO TYPES OF CRYSTALLINE OF PINOCEMBRIN: A AND B, THEIR PREPARATION AND THEIR USE FOR MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS 有权TWO松属素晶体的类型：A和B，用于制造药物组合物的生产和使用
公开(公告)号：EP2360152A4
公开(公告)日：2012-05-30
申请号：EP08878072
申请日：2008-11-13
发明人： DU GUANHUA , LV YANG , WU SONG , WANG KE , CHANG YING , YANG ZHIHONG , TONG YUANFENG , GAO MEI
IPC分类号： C07D311/22 , A61K31/353 , A61P9/10 , C07D311/32
CPC分类号： C07D311/22 , A61K31/353 , C07D403/04 , C07D403/08
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9.发明公开ARYLAMINE KETONES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 有权ARYLAMINKETONE，PROCESS FOR及其药物组合物含有它们及其用途
公开(公告)号：EP1783115A4
公开(公告)日：2010-04-07
申请号：EP05774475
申请日：2005-08-05
发明人： ZHU LIYA , WANG WENJIE , HUANG HAIHONG , LIN ZIYUN , MOU LIYUAN , NIE ZHENGUI , HE YU , OUYANG XUEYU , PENG SHANYING , ZHANG DONGFENG , WEI JUN
IPC分类号： C07D211/14 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/535 , A61K31/5375 , A61P7/02 , A61P29/00 , C07D211/18 , C07D211/20 , C07D211/22 , C07D211/36 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D241/04 , C07D265/30 , C07D265/32 , C07D295/108 , C07D295/15
CPC分类号： C07D295/205 , C07D211/14 , C07D211/22 , C07D211/60 , C07D211/62 , C07D241/04 , C07D295/108 , C07D295/185 , C07D317/58 , C07D405/06
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10.发明公开SUBMICRO EMULSION OF PACLITAXEL USING STEROID COMPLEX AS INTERMEDIATE CARRIER 审中-公开紫杉醇与类固醇复杂得多，运营商之间的亚微米乳液。
公开(公告)号：EP2494957A4
公开(公告)日：2014-04-16
申请号：EP10826102
申请日：2010-10-28
发明人： LIU YULING , XIA XUEJUN , GUO RUIFANG , ZHANG PENGXIAO , HAN RUI , FU ZHAODI , ZHOU CUIPING , WANG RENYUN , JIN DUJIA
IPC分类号： A61K9/107 , A61K31/337 , A61K47/28 , A61K47/44 , A61P35/00
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/337 , A61K47/28 , A61K47/44
摘要： A submicron emulsion of paclitaxel, the preparation method and the use thereof are disclosed. Said paclitaxel submicron emulsion comprises paclitarxel/steroid complex, oil for injection, water for injection, emulsifier, assistant emulsifier and isotonic agent, wherein the mole ratio of paclitaxel to steroid in the complex is 1:0.2ˆ¼4; preferably 1:0.25-2. Said submicron emulsion is useful for the treatment for malignant tumor. The average particle diameter of the submicron emulsion is less than 400 nm and the pH Value is 3.5-6.
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