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公开(公告)号：EP3145951A1
公开(公告)日：2017-03-29
申请号：EP15739029.5
申请日：2015-06-24
发明人： PINKUS, Ronny , BUTBUL, Meir
CPC分类号： C07K1/36 , C07K1/165 , C07K1/18 , C07K1/22 , C07K16/00 , C07K16/241 , C07K2317/21 , C07K2317/24 , C07K2317/76
摘要： Methods of purifying an antibody (Ab) from a mixture comprising impurities are disclosed. One method comprises: (a) purifying the Ab using an affinity resin; (b) purifying the Ab using a cation exchange (CEX) resin; and (c) purifying the Ab using a mixed mode (MM) resin which comprises anion exchange and hydrophobic interaction functional groups; wherein step (b) follows step (a) and step (c) follows step (b), and wherein the method does not comprise use of a hydrophobic interaction chromatography (HIC) medium, thereby purifying the Ab.
摘要翻译： 公开了从包含杂质的混合物中纯化抗体（Ab）的方法。 一种方法包括：（a）使用亲和树脂纯化Ab; （b）使用阳离子交换（CEX）树脂纯化Ab; 和（c）使用包含阴离子交换和疏水相互作用官能团的混合模式（MM）树脂纯化Ab; 其中步骤（b）遵循步骤（a）和步骤（c）遵循步骤（b），并且其中所述方法不包括使用疏水相互作用层析（HIC）培养基，从而纯化Ab。
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公开(公告)号：EP1676912A3
公开(公告)日：2008-12-31
申请号：EP06004005.2
申请日：1998-08-31
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , A61M15/009 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A polynucleotide ( hpa ) encoding a polypeptide having heparanase activity, vectors including same, transduced cells expressing heparanase and a recombinant protein having heparanase activity.
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3.发明公开METHODS AND KITS UTILIZING HEPARANASE AS A DIAGNOSTIC MARKER FOR HAEMOSTATIC DISORDERS 审中-公开使用肝素酶作为治疗静脉炎的诊断标记物的方法和试剂盒
公开(公告)号：EP1385990A4
公开(公告)日：2004-09-22
申请号：EP02728008
申请日：2002-05-09
发明人： YACOBY-ZEEVI ORON
IPC分类号： G01N33/573 , C12Q1/10 , G01N33/53 , G01N33/537
CPC分类号： G01N33/573 , G01N2333/924 , G01N2800/52
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公开(公告)号：EP1439193B1
公开(公告)日：2013-08-28
申请号：EP04001481.3
申请日：1998-08-31
IPC分类号： C12N15/56 , C12N15/63 , C12N1/21 , C12N9/24 , C12N15/11 , A61K38/47 , C07K16/40 , G01N33/573 , A61K39/395
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , A61M15/009 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
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公开(公告)号：EP1126878B1
公开(公告)日：2009-09-16
申请号：EP99956781.1
申请日：1999-10-28
发明人： PERETZ, Tuvia , MIRON, Daphna , SHLOMI, Yinon , PECKER, Iris , AYAL-HERSHKOVITZ, Maty , FRIEDMAN, Yael , VLODAVSKY, Israel
IPC分类号： A61K39/395 , A61K38/47 , C07K16/40
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
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6.发明公开Heparanase specific molecular probes and their use in research and medical applications 审中-公开肝素酶特异性分子探针，以及他们在研究和医疗应用
公开(公告)号：EP1734133A2
公开(公告)日：2006-12-20
申请号：EP06009462.0
申请日：1999-04-29
发明人： Pecker, Iris , Friedman, Yael , Vlodavski, Israel , Perets, Tuvia
IPC分类号： C12Q1/68 , C07K16/40 , A61K51/10 , G01N33/573 , A61K39/395 , A61P35/00 , A61P13/12 , A61P3/10 , A61P37/00
CPC分类号： A61M15/009 , A61K38/00 , C07K16/40 , C12N9/2402 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40 , Y10S977/906
摘要： A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
摘要翻译： 各种哪个可以用于研究和医学应用，包括诊断和治疗的乙酰肝素酶的特异性分子探针。 具体的应用包括使用用于检测的存在，不存在或乙酰肝素酶表达的水平的乙酰肝素酶特异性分子探针; 使用用于与乙酰肝素酶的表达有关的病症的治疗中的乙酰肝素酶特异性分子探针; 使用用于在体液肝素酶定量的乙酰肝素酶特异性分子探针; 使用用于靶向药物递送的乙酰肝素酶特异性分子探针; 和使用乙酰肝素酶特异性分子探针的作为治疗剂。
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公开(公告)号：EP1720828A2
公开(公告)日：2006-11-15
申请号：EP05703192.4
申请日：2005-02-06
发明人： VAN GELDER, Joel M. , BASEL, Yochai , KRAIZ, Boris O. , MOUALLEM, Orly , MIRON, Daphna , GUR-ARIE, Nina , KLEIN, Joseph
IPC分类号： C07C257/18 , C07C257/00
CPC分类号： A61K31/415 , A61K31/136 , A61K31/16 , A61K31/185 , A61K31/21
摘要： The invention provides heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.
摘要翻译： 本发明提供了适用于治疗由乙酰肝素酶催化活性引起的或与之相关的疾病和病症的乙酰肝素酶抑制剂，所述疾病和病症例如癌症，炎性病症和自身免疫性疾病。
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8.发明授权HEPARANASE SPECIFIC MOLECULAR PROBES AND THEIR USE IN RESEARCH AND MEDICAL APPLICATIONS 有权乙酰肝素酶特异性分子探针和它们在研究和医疗应用
公开(公告)号：EP1073682B1
公开(公告)日：2006-05-31
申请号：EP99921513.0
申请日：1999-04-29
发明人： PECKER, Iris , VLODAVSKY, Israel , FRIEDMAN, Yael , PERETS, Tuvia
CPC分类号： A61M15/009 , A61K38/00 , C07K16/40 , C12N9/2402 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40 , Y10S977/906
摘要： A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
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公开(公告)号：EP1439193A3
公开(公告)日：2004-10-06
申请号：EP04001481.3
申请日：1998-08-31
IPC分类号： C12N15/56 , C12N15/63 , C12N1/21 , C12N9/24 , C12N15/11 , A61K38/47 , C07K16/40 , G01N33/573 , A61K39/395
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , A61M15/009 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： An antibody specifically binding to at least one epitope of a heparanase protein.
摘要翻译： 特异性结合乙酰肝素酶蛋白的至少一个表位的抗体。
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10.发明公开METHODS AND KITS UTILIZING HEPARANASE AS A DIAGNOSTIC MARKER FOR HAEMOSTATIC DISORDERS 审中-公开方法和药盒作为诊断标志物乙酰肝素酶止血疾病
公开(公告)号：EP1385990A1
公开(公告)日：2004-02-04
申请号：EP02728008.0
申请日：2002-05-09
发明人： YACOBY-ZEEVI, Oron
IPC分类号： C12Q1/10 , G01N33/53 , G01N33/573 , G01N33/537
CPC分类号： G01N33/573 , G01N2333/924 , G01N2800/52
摘要： Provided is a method of determining a presence, absence, or severity of a haemostatic disorder in a subject. The method is effected by determining a level of heparanase expression or activity in a biological sample obtained from the subject. Also provided are kits for use with the method.
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