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公开(公告)号：EP1126878B1
公开(公告)日：2009-09-16
申请号：EP99956781.1
申请日：1999-10-28
发明人： PERETZ, Tuvia , MIRON, Daphna , SHLOMI, Yinon , PECKER, Iris , AYAL-HERSHKOVITZ, Maty , FRIEDMAN, Yael , VLODAVSKY, Israel
IPC分类号： A61K39/395 , A61K38/47 , C07K16/40
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
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公开(公告)号：EP1126878A1
公开(公告)日：2001-08-29
申请号：EP99956781.1
申请日：1999-10-28
发明人： PERETZ, Tuvia , MIRON, Daphna , SHLOMI, Yinon , PECKER, Iris , AYAL-HERSHKOVITZ, Maty , FRIEDMAN, Yael , VLODAVSKY, Israel
IPC分类号： A61K39/395 , A61K38/47 , C07K16/40
CPC分类号： C07K16/40 , A61K38/00 , A61K2039/505 , C12N9/2402 , C12Y302/01166 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
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3.发明公开METHOD OF SCREENING FOR POTENTIAL ANTI-METASTATIC AND ANTI-INFLAMMATORY AGENTS USING MAMMALIAN HEPARANASE AS A PROBE 审中-公开筛选方法，潜在的抗METASTASISCHE-和抗炎剂使用哺乳动物乙酰肝素酶为探针
公开(公告)号：EP1097241A1
公开(公告)日：2001-05-09
申请号：EP99932382.7
申请日：1999-07-12
发明人： BEN-ARTZI, Hanna , AYAL-HERSHKOVITZ, Maty , VLODAVSKY, Israel , PECKER, Iris , PELEG, Yoav , MIRON, Daphna
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , C12N9/2402 , C12Q1/34 , C12Q1/527 , G01N2333/924 , G01N2333/988 , G01N2400/40 , G01N2500/20
摘要： Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.
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4.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING HEPARANASE ACTIVATION AND USES THEREOF 审中-公开对于调制和方法和药物组合物及其用途HEPARANASEAKTIVIERUNG
公开(公告)号：EP1654380A2
公开(公告)日：2006-05-10
申请号：EP04745083.8
申请日：2004-08-12
CPC分类号： C12Q1/37 , A61K31/075 , A61K38/57
摘要： Methods of identifying proteases participating in heparanase activation, methods and pharmaceutical compositions useful in modulating heparanase activation and methods of modulating biological processes depending, at least in part, on heparanase activity are disclosed.
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公开(公告)号：EP1720828A2
公开(公告)日：2006-11-15
申请号：EP05703192.4
申请日：2005-02-06
发明人： VAN GELDER, Joel M. , BASEL, Yochai , KRAIZ, Boris O. , MOUALLEM, Orly , MIRON, Daphna , GUR-ARIE, Nina , KLEIN, Joseph
IPC分类号： C07C257/18 , C07C257/00
CPC分类号： A61K31/415 , A61K31/136 , A61K31/16 , A61K31/185 , A61K31/21
摘要： The invention provides heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.
摘要翻译： 本发明提供了适用于治疗由乙酰肝素酶催化活性引起的或与之相关的疾病和病症的乙酰肝素酶抑制剂，所述疾病和病症例如癌症，炎性病症和自身免疫性疾病。
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