公开(公告)号：EP1848432B1

公开(公告)日：2013-07-17

申请号：EP06715982.2

申请日：2006-02-15

申请人： Md Bioalpha Co., Ltd. ,  KT & G Co., Ltd.

发明人： YOO, Sang-Ku ,  PARK, Myunggyu ,  JO, In Geun ,  KWAK, Taehwan

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P1/16 ,  A61P9/10 ,  A61P29/00 ,  A61P27/02 ,  A61P9/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/343

CPC分类号： A61K31/352 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/146 ,  A61K9/2054 ,  A61K31/343 ,  A61K31/353 ,  A61K31/453 ,  A61Q19/00

摘要： Provided is a pharmaceutical composition for the treatment and prevention of obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, comprising: a therapeutically effective amount of a compound represented by Formula I below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.

公开(公告)号：EP2532389A3

公开(公告)日：2013-02-20

申请号：EP12175606.8

申请日：2006-02-15

申请人： Md Bioalpha Co., Ltd.

发明人： Yoo, Sang-Ku ,  Park, Myunggyu ,  Jo, In Geum ,  Kwak, Tae-hwan

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P1/16 ,  A61P9/10 ,  A61P29/00 ,  A61P27/02 ,  A61P9/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/343

CPC分类号： A61K31/352 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/146 ,  A61K9/2054 ,  A61K31/343 ,  A61K31/353 ,  A61K31/453 ,  A61Q19/00

摘要： Provided is a pharmaceutical composition for the treatment and prevention of obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, comprising: a therapeutically effective amount of a compound represented by Formula I below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.

公开(公告)号：EP2426212A1

公开(公告)日：2012-03-07

申请号：EP11179000.2

申请日：2007-02-15

申请人： Md Bioalpha Co., Ltd.

发明人： Park, Myung-Gyu ,  Yoo, Sang-Ku ,  Jo, In Geun ,  Kwak, Taehwan

IPC分类号： C12Q1/26

CPC分类号： C12Q1/26 ,  A61K31/12 ,  A61K31/343 ,  A61K38/44 ,  C12Y106/05002

摘要： The present invention provides a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochrondrial dysfunction-related diseases, via elevation of an NAD(P) + ZNAD(P)H ratio by increasing an NAD(P) + concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinine oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.

摘要翻译： 本发明提供一种能够通过升高NAD（P）+ ZNAD（P）H比例来有效治疗与能量过量相关的各种疾病，例如肥胖症，糖尿病，代谢综合征，退行性疾病和线粒体功能障碍相关疾病的方法 通过使用NAD（P）H作为底物或通过氧化还原酶如NAD（P）H：奎宁氧化还原酶（NQO1）的氧化还原酶的辅酶，在体内或体外增加NAD（P）+浓度， 相同和治疗药物。

公开(公告)号：EP1706108A4

公开(公告)日：2009-08-12

申请号：EP04808674

申请日：2004-12-30

申请人： MD BIOALPHA CO LTD ,  KT & G CO LTD

发明人： KWAK TAEHWAN ,  PARK MYUNGGYU

IPC分类号： A61K36/537 ,  A23C9/152 ,  A23L1/30 ,  A23L2/02 ,  A23L2/52 ,  A61K9/00 ,  A61K31/343 ,  A61K36/00 ,  A61P3/04

CPC分类号： A61Q19/06 ,  A23C9/152 ,  A23L2/02 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/4973 ,  A61K9/0095 ,  A61K9/2054 ,  A61K31/343 ,  A61K36/537 ,  A61K2300/00 ,  A23V2250/0606 ,  A23V2250/032 ,  A23V2250/704 ,  A23V2200/332 ,  A23V2200/328 ,  A23V2200/326 ,  A23V2250/708 ,  A23V2250/606 ,  A23V2250/5042

摘要： The present invention relates to a composition for preventing and treating metabolic syndrome, containing tanshinone derivatives as an effective ingredient. More specifically, the present invention relates to a composition for preventing and treating metabolic syndrome, containing tanshinone derivatives that exhibit superior activity in enhancing metabolic activity, as an effective ingredient.

摘要翻译： 本发明涉及一种组合物，用于预防和治疗代谢综合征，含丹参酮衍生物作为有效成分。 更具体地，本发明涉及用于预防和治疗代谢综合征，含丹参酮衍生物的组合物的确显示出优越的活性增强的代谢活性，作为有效成分。

公开(公告)号：EP2532389A2

公开(公告)日：2012-12-12

申请号：EP12175606.8

申请日：2006-02-15

申请人： Md Bioalpha Co., Ltd.

发明人： Yoo, Sang-Ku ,  Park, Myunggyu ,  Jo, In Geum ,  Kwak, Tae-hwan

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P1/16 ,  A61P9/10 ,  A61P29/00 ,  A61P27/02 ,  A61P9/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/343

CPC分类号： A61K31/352 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/146 ,  A61K9/2054 ,  A61K31/343 ,  A61K31/353 ,  A61K31/453 ,  A61Q19/00

摘要： Provided is a pharmaceutical composition for the treatment and prevention of obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, comprising: a therapeutically effective amount of a compound represented by Formula I below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.

摘要翻译： 本发明提供用于治疗和预防肥胖症，糖尿病，代谢综合症，退行性疾病和线粒体功能障碍相关疾病的药物组合物，其包含：治疗有效量的由下式I表示的化合物或其药学上可接受的盐，前药， 溶剂化物或异构体，以及药学上可接受的载体，稀释剂或赋形剂或其任何组合。

公开(公告)号：EP1848432A1

公开(公告)日：2007-10-31

申请号：EP06715982.2

申请日：2006-02-15

申请人： Md Bioalpha Co., Ltd. ,  KT & G Co., Ltd.

发明人： YOO, Sang-Ku ,  PARK, Myunggyu, 107-302, Seogeunaemaeul SK Apt. ,  JO, In Geun, 405-701, Dujeong 4-cha prugio Apt. ,  KWAK, Taehwan, 103-503, Seogeunaemaeul SK Apt.

IPC分类号： A61K31/453 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/352 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/146 ,  A61K9/2054 ,  A61K31/343 ,  A61K31/353 ,  A61K31/453 ,  A61Q19/00

摘要： Provided is a pharmaceutical composition for the treatment and prevention of obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, comprising: a therapeutically effective amount of a compound represented by Formula I below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.

公开(公告)号：EP1507544A4

公开(公告)日：2007-07-18

申请号：EP03725845

申请日：2003-05-28

申请人： MD BIOALPHA CO LTD

发明人： KWAK TAE HWAN ,  SHIN MYOUNG SOOK ,  KIM JI YEON ,  PARK JONG-KOOK

IPC分类号： A61K9/08 ,  A23L1/30 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/191 ,  A61K31/225 ,  A61K31/337 ,  A61K31/675 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/702 ,  A61K31/715 ,  A61K33/24 ,  A61K36/00 ,  A61K36/25 ,  A61K36/254 ,  A61K36/258 ,  A61K45/00 ,  A61P7/00 ,  A61P7/06 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P35/04 ,  A61P37/04 ,  A61P39/00 ,  A61P43/00 ,  A61K35/78

CPC分类号： A61K36/258 ,  A23L33/105 ,  A61K31/191 ,  A61K31/225 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/702 ,  A61K2300/00

摘要： Provided is a composition that contains, as an active ingredient, an extract or polysaccharides separated from the leaves and/or stems of plants belonging to Panax genus, for an anticancer drug or its adjuvant, having an effect on the activity of hematopoiesis enhancement, cancer metastasis inhibition, bone marrow defense, etc. . . . , and a process for preparation of the extract from the leaves and/or stems of plants belonging to Panax genus.

公开(公告)号：EP1507544A1

公开(公告)日：2005-02-23

申请号：EP03725845.6

申请日：2003-05-28

申请人： Md Bioalpha Co., Ltd.

发明人： KWAK, Tae Hwan103-503, Seogeunaemaeul SK Apt. ,  SHIN, Myoung Sook611, Samjeongateutel ,  KIM, Ji Yeon ,  PARK, Jong-Kook

IPC分类号： A61K35/78

CPC分类号： A61K36/258 ,  A23L33/105 ,  A61K31/191 ,  A61K31/225 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/702 ,  A61K2300/00

摘要： Provided is a composition that contains, as an active ingredient, an extract or polysaccharides separated from the leaves and/or stems of plants belonging to Panax genus, for an anticancer drug or its adjuvant, having an effect on the activity of hemotopoiesis enhancement, cancer metastasis inhibition, bone marrow defense, etc…, and a process for preparation of the extract from the leaves and/or stems of plants belonging to Panax genus.

公开(公告)号：EP2532390B1

公开(公告)日：2016-08-17

申请号：EP12175609.2

申请日：2006-02-15

申请人： Md Bioalpha Co., Ltd.

发明人： Yoo, Sang-Ku ,  Park, Myunggyu ,  Jo, In Geum ,  Kwak, Tae-hwan

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P1/16 ,  A61P9/10 ,  A61P29/00 ,  A61P27/02 ,  A61P9/12 ,  A61K31/352 ,  A61K31/353 ,  A61K31/343

CPC分类号： A61K31/352 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/146 ,  A61K9/2054 ,  A61K31/343 ,  A61K31/353 ,  A61K31/453 ,  A61Q19/00

摘要： Provided is a pharmaceutical composition for the treatment and prevention of obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, comprising: a therapeutically effective amount of a compound represented by Formula I below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.

公开(公告)号：EP1765393A1

公开(公告)日：2007-03-28

申请号：EP05765959.1

申请日：2005-07-02

申请人： Md Bioalpha Co., Ltd.

发明人： Ha, Joohun ,  Park, Myunggyu, 107-302, Seogeunaemaeul SK Apt.

IPC分类号： A61K39/235

CPC分类号： A61K45/06

摘要： Provided is herein a method for enhancing therapeutic effects of an anti-cancer drug by inhibition of AMPK activity in conjunction with use of an anti-cancer drug for inhibiting proliferation and/or metastasis of cancer. The method in accordance with the present invention can significantly enhance therapeutic effects of an anti-cancer drug via inhibition of AMPK activity and therefore is very useful in inhibition of cancer proliferation and metastasis, utilizing anti-cancer drugs. Further, the present invention enables use of conventional anti-cancer drugs for cancer cells having drug- resistance to such anti-cancer drugs.