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公开(公告)号：EP2955226B1
公开(公告)日：2019-06-26
申请号：EP14748891.0
申请日：2014-02-07
发明人： ONO, Kenichiro , YAGI, Kasumi
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公开(公告)号：EP3121273A1
公开(公告)日：2017-01-25
申请号：EP15764290.1
申请日：2015-03-20
申请人： JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES , Medical & Biological Laboratories Co., Ltd. , Toray Industries, Inc.
IPC分类号： C12N15/00 , A61K39/395 , A61P1/16 , A61P31/14 , C07K16/10 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/576
CPC分类号： C07K16/109 , C07K2317/40 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , G01N33/5767
摘要： The present invention provides an anti-hepatitis C virus E2 protein antibody or antigen-binding antibody fragment thereof having infection inhibiting activity against hepatitis C virus (HCV). The present invention further provides an anti-hepatitis C virus E2 protein antibody or antigen-binding antibody fragment thereof comprising a certain variable region, which have infection inhibiting activity against hepatitis C virus (HCV) and exhibits an escape mutant emergence suppressive property.
摘要翻译： 本发明提供具有针对丙型肝炎病毒（HCV）的感染抑制活性的抗丙型肝炎病毒E2蛋白抗体或其抗原结合抗体片段。 本发明还提供一种抗丙型肝炎病毒E2蛋白质抗体或其抗原结合抗体片段，其包含具有针对丙型肝炎病毒（HCV）的感染抑制活性并具有逃避突变体出苗抑制性质的某一可变区。
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3.发明公开
公开(公告)号：EP2881467A1
公开(公告)日：2015-06-10
申请号：EP13825402.4
申请日：2013-07-30
申请人： National University Corporation Nagoya University , Medical & Biological Laboratories Co., Ltd.
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/18 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/90
摘要： A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.
摘要翻译： 已经发现，在人类midkine的位置69，位置79，位置81和位置102的氨基酸中识别至少两个氨基酸的单克隆抗体具有优异的与人类midkine的反应性和优异的中和活性。 此外，在具有优异的中和活性的抗体中观察到抑制肿瘤增殖的活性。 使用本发明的抗体可以有效地治疗癌症并有效地检测或纯化中期因子。
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公开(公告)号：EP1548107B1
公开(公告)日：2011-01-12
申请号：EP03792798.5
申请日：2003-08-22
CPC分类号： G01N33/542 , C07K14/37 , C07K2319/00 , G01N33/533 , G01N33/582 , G01N2021/6439 , G01N2500/10
摘要： It is intended to provide a novel chromoprotein and novel fluoroproteins. Namely, a chromoprotein originating in Anthopleure inornata and having definite properties; and fluoroproteins originating in Trachyphyllia geoffroyi and Scolymia vitiensis and having definite fluorescent properties.
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5.发明授权
公开(公告)号：EP2990418B1
公开(公告)日：2018-12-12
申请号：EP14787867.2
申请日：2014-04-17
发明人： ONO, Kenichiro , AKATSUKA, Junichi
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00 , C12N5/10 , C12N15/09
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/34 , C07K2317/732 , C07K2317/76
摘要： Two types of antibodies (35-1 antibody and 292 antibody) capable of binding to phenylalanine at position 115, isoleucine at position 117, glycine at position 140, glutamic acid at position 141, and arginine at position 142 of a human HB-EGF protein were successfully obtained. Then, it was also found that these antibodies had an activity of suppressing cleavage of the human HB-EGF protein, and an activity of suppressing EGFR phosphorylation that would occur when the human HB-EGF bound to the EGFR. Further, determined were amino acid sequences of light chain and heavy chain variable regions of these antibodies and sequences of CDRs of each of the variable regions.
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公开(公告)号：EP2881467B1
公开(公告)日：2018-10-31
申请号：EP13825402.4
申请日：2013-07-30
申请人： National University Corporation Nagoya University , Medical & Biological Laboratories Co., Ltd.
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/18 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C07K16/22
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/90
摘要： A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.
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公开(公告)号：EP3156484A4
公开(公告)日：2017-12-27
申请号：EP15806561
申请日：2015-06-10
发明人： WATANABE TAKU , SHOJI TORU , MATSUZAWA SHUN
CPC分类号： G01N33/5005 , C07K14/435 , C07K14/43504 , C07K2319/00 , C07K2319/60 , C07K2319/70 , C12N15/09 , C12Q1/02 , G01N33/582 , G01N33/6845
摘要： A method for determining an interaction between a first protein and a second protein comprises the steps of: expressing in a cell or introducing into a cell a first fusion protein comprising the first protein, a multimerizable protein, and a fluorescent protein, and a second fusion protein comprising the second protein and a multimerizable protein; detecting a fluorescent focus formed by an association between the first fusion protein and the second fusion protein in the cell; and determining an interaction between the first protein and the second protein according to the detection of the fluorescent focus.
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8.发明公开FUNCTIONAL MONOCLONAL ANTIBODY AGAINST HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR 审中-公开功能性单克隆抗体的肝素结合表皮生长因子样生长因子
公开(公告)号：EP2990418A1
公开(公告)日：2016-03-02
申请号：EP14787867.2
申请日：2014-04-17
发明人： ONO, Kenichiro , AKATSUKA, Junichi
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00 , C12N5/10 , C12N15/09
CPC分类号： C07K16/22 , C07K2317/24 , C07K2317/34 , C07K2317/732 , C07K2317/76
摘要： Two types of antibodies (35-1 antibody and 292 antibody) capable of binding to phenylalanine at position 115, isoleucine at position 117, glycine at position 140, glutamic acid at position 141, and arginine at position 142 of a human HB-EGF protein were successfully obtained. Then, it was also found that these antibodies had an activity of suppressing cleavage of the human HB-EGF protein, and an activity of suppressing EGFR phosphorylation that would occur when the human HB-EGF bound to the EGFR. Further, determined were amino acid sequences of light chain and heavy chain variable regions of these antibodies and sequences of CDRs of each of the variable regions.
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公开(公告)号：EP1642969B1
公开(公告)日：2009-09-16
申请号：EP04746255.1
申请日：2004-06-16
发明人： MIYAWAKI, Atsushi c/o RIKEN , TSUTSUI, Hidekazu c/o RIKEN , KARASAWA, Satoshi MEDICAL & BIOLOGICAL LAB. CO.LTD
IPC分类号： C12N15/09 , C12N1/21 , C12N5/10 , C07K14/435 , C07K19/00 , C12Q1/02 , G01N33/50 , G01N33/533
CPC分类号： C07K14/43504
摘要： A novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum; and a novel pigment protein derived from Actinia equina.
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10.发明公开METHOD OF CONSTRUCTING RECOMBINANT PROTEOLIPOSOME FOR DIAGNOSTIC USE 有权VERFAHREN ZUR KONSTRUKTION EINES REKOMBINANTEN PROTEOLIPOSOMS ZUR DIAGNOSTISCHEN VERWENDUNG
公开(公告)号：EP1992688A1
公开(公告)日：2008-11-19
申请号：EP07714229.7
申请日：2007-02-15
IPC分类号： C12N15/00 , C12M1/00 , C12N15/09 , G01N33/549 , G01N33/564 , G01N33/58 , G01N33/68
CPC分类号： G01N33/5432 , C12N15/86 , C12N15/88 , C12N2710/14143 , C12N2810/855 , G01N33/564 , G01N33/56983 , G01N2333/01 , G01N2469/20
摘要： [PROBLEMS] To provide a method for preparation of recombinant proteoliposomes suitable for diagnostic applications, a detection plate coated with the recombinant proteoliposomes, a detection kit and so on.
[PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, β1 adrenalin receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.摘要翻译： [问题]提供一种适用于诊断应用的重组蛋白脂质体的制备方法，用重组蛋白脂质体包被的检测板，检测试剂盒等。 [问题解决方案]重组蛋白脂质体通过表达靶膜受体（例如人类促甲状腺激素受体，乙酰胆碱受体，胰岛素受体，β肾上腺素受体，脱唾液酸糖蛋白受体等）的重组杆状病毒的发芽病毒颗粒的融合而制备 ，各自参与自身抗体相关疾病），与脂质体。 与重组杆状病毒相比，这些蛋白脂质体具有改进的与自身抗体结合的能力，并且使得可以容易地制备用于其检测的试剂盒。
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