公开(公告)号：EP1702072A4

公开(公告)日：2007-03-21

申请号：EP03767310

申请日：2003-12-23

申请人： MURDOCH CHILDRENS RES INST

发明人： CHOO ANDY ,  SAFFERY RICHARD ERIC ,  WONG LEE HWA

IPC分类号： C12N15/85 ,  A61K48/00 ,  C12N15/12 ,  C12N15/79 ,  C12N15/82 ,  C12N15/90

CPC分类号： A61K48/005 ,  C12N15/82 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/002 ,  C12N2830/003 ,  C12N2830/15 ,  C12N2830/46

摘要： The present invention provides a target region within a mammalian, avian, plant or other eukaryotic chromosome or an artificial or engineered chromosomal construct which is capable of carrying and expressing a heterologous gene or other genetic molecule of interest. The gene or genetic molecule of interest is expressed in a region of the chromosome which corresponds to or which immediately adjoins or is proximal to a centromeric or neocentromeric region or a functional derivative thereof or a latent, synthetic or hybrid form thereof. A method for facilitating genetic therapy or genetic modification or other applications are also provided including protein production for proteomic therapy in a mammal, avian species or plant or other higher eukaryotes.

公开(公告)号：EP2948565A4

公开(公告)日：2016-09-21

申请号：EP14743573

申请日：2014-01-24

申请人： MURDOCH CHILDRENS RES INST

发明人： GODLER DAVID ,  INABA YOSHIMI

IPC分类号： C12Q1/68 ,  G06F19/22

CPC分类号： C12Q1/6883 ,  C12Q1/6851 ,  C12Q2600/154 ,  G06F19/24 ,  C12Q2523/125 ,  C12Q2527/107 ,  C12Q2545/113 ,  C12Q2561/113

摘要： An assay quantifies the extent of methylation in a DNA sample. Kits and clinical diagnostic assays include assays to determine clinical phenotypes based on extent of methylation of a DNA target site.

公开(公告)号：EP2680921A4

公开(公告)日：2014-09-10

申请号：EP12752697

申请日：2012-03-02

申请人： MURDOCH CHILDRENS RES INST

发明人： SOUTHWELL BRIDGET RAE ,  HUTSON JOHN MEDWYN ,  TAN ANDRE YI FENG

IPC分类号： A61N1/24 ,  A61N1/36 ,  A61N1/375 ,  G06F15/00

CPC分类号： A61N1/36007 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/36014

摘要： A method of treating a waste evacuation dysfunction comprising administering transcutaneous electrical stimulation (TES) to at least one lower pelvic and/or sacral region for a specific treatment regimens. Also disclosed is a system for configuring a stimulation device to deliver transcutaneous electrical stimulation (TES) the system comprising: a computing device storing or having access to a plurality or TES settings and comprising a user interface to enable authorized selection of at least on of the TES settings for provision of TES by the stimulation device according to the at least one selected TES setting and the stimulation device communicatively coupled to the computing device to receive and store the selected at least one TES setting the stimulation device being of a size to be readily carried on a body and configured to selectively provide current to external electrode according to the one TES setting.

摘要翻译： 一种治疗废物排泄功能障碍的方法，其包括对至少一个下盆骨和/或骶骨区域进行经皮电刺激（TES）用于特定治疗方案。 还公开了一种用于配置刺激装置以递送经皮电刺激（TES）的系统，所述系统包括：计算装置，其存储或具有对多个或TES设置的访问，并且包括用户界面，以使得至少能够 TES设置，用于根据所述至少一个选择的TES设置由刺激装置提供TES，以及通信地耦合到所述计算设备的所述刺激装置，以接收和存储所选择的至少一个TES设置，所述刺激装置具有容易的尺寸 承载在主体上并被配置为根据一个TES设置选择性地向外部电极提供电流。

公开(公告)号：EP2603609A4

公开(公告)日：2013-11-27

申请号：EP11815911

申请日：2011-08-11

申请人： MURDOCH CHILDRENS RES INST

发明人： GODLER DAVID EUGENY

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/68 ,  C12Q2600/154 ,  G06F19/24

公开(公告)号：EP2398917A4

公开(公告)日：2012-07-25

申请号：EP10743317

申请日：2010-02-17

申请人： MURDOCH CHILDRENS RES INST

发明人： GODLER DAVID EUGENY

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2523/125 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/156

公开(公告)号：EP1765990A4

公开(公告)日：2008-07-09

申请号：EP05742151

申请日：2005-05-19

申请人： MELBOURNE HEALTH ,  MURDOCH CHILDRENS RES INST

发明人： LOCARNINI STEPHEN ,  VISVANATHAN KUMAR

IPC分类号： C12N7/00 ,  A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  C07K14/02 ,  C12N15/12 ,  C12N15/51 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/706 ,  A61K38/162 ,  A61K39/00 ,  C07K14/005 ,  C12N2730/10122 ,  C12Q2600/158

公开(公告)号：EP1354055A4

公开(公告)日：2004-07-07

申请号：EP01271443

申请日：2001-12-20

申请人： MURDOCH CHILDRENS RES INST

发明人： CHOO KONG-HONG ANDY ,  WONG LEE HWA ,  SAFFERY RICHARD ERIC

IPC分类号： G01N33/53 ,  A61K31/7088 ,  A61K48/00 ,  C12N5/10 ,  C12N15/09 ,  C12N15/68 ,  C12N15/85 ,  C12Q1/68 ,  G01N33/566 ,  C12N15/64 ,  C12N15/79

CPC分类号： C12N15/68 ,  A61K48/00 ,  C12N15/85 ,  C12N2800/204 ,  C12N2800/30

摘要： The present invention is directed generally to a defined or isolated nucleic acid molecule encompassing a neocentreomere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic mini-chromosomes and artificial chromosomes including mammalian (e.g. human) and non-mammalian mini-chromosomes and artificial chromosomes. The present invention further provides a telomere-associated chromosome truncation (TACT) approach to develop mini-chromosomes, but is not limited to this approach. It is directed to any truncation approach that produces a neocentromere-containing mini-chromosome, or any transfection approach using cloned or pre-fabricated DNA that provides neocentromere function in the construction of artificial chromosome. Such mini-chromosomes and artificial chromosomes are useful in a range of genetic therapies.

公开(公告)号：EP2723902A4

公开(公告)日：2015-02-18

申请号：EP12803257

申请日：2012-06-22

申请人： MURDOCH CHILDRENS RES INST

发明人： GODLER DAVID EUGENY

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/154 ,  G06F19/22

公开(公告)号：EP2393351A4

公开(公告)日：2012-09-26

申请号：EP10738167

申请日：2010-02-08

申请人： UNIV MELBOURNE ,  MURDOCH CHILDRENS RES INST

发明人： SINCLAIR ANDREW ,  SMITH CRAIG ,  LOWENTHAL JOHN WILLIAM ,  MOORE ROBERT JOHN ,  DORAN TIMOTHY JAMES

IPC分类号： A01K67/02 ,  A01D19/00 ,  A01K67/027 ,  C07K14/465 ,  C12N15/85

CPC分类号： A01K67/02 ,  A01K67/0275 ,  A01K2217/00 ,  A01K2217/058 ,  A01K2227/30 ,  A01K2267/02 ,  C07K14/465 ,  C12N15/8509 ,  C12N2799/027 ,  G06Q99/00

公开(公告)号：EP1390501A4

公开(公告)日：2005-03-30

申请号：EP02719561

申请日：2002-05-03

申请人： MURDOCH CHILDRENS RES INST ,  DELATYCKI MARTIN

发明人： WILLIAMSON ROBERT ,  DAHL HANS-HENRIK ,  FORREST SUSAN MARY ,  WILCOX STEPHEN ANDREW ,  DE SILVA MICHELLE GINA ,  ELLIOTT KATHERINE SEYMOUR ,  LYNCH MICHAEL

IPC分类号： C07K14/47 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K14/705 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/6893 ,  G01N2800/305

摘要： A molecular marker of a behavioural disorder, including Attention Deficit Hyperactivity Disorder (ADHD) and intellectual disorders and its use in the diagnosis of a behavioural disorder or an assessment of a likelihood that a subject may develop the behavioural disorder. The molecular marker may be in the form of a proteinaceous molecule or a genetic sequence.