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公开(公告)号：EP0881228B1
公开(公告)日：2005-08-10
申请号：EP98109492.3
申请日：1998-05-26
申请人： PNA Diagnostics A/S
CPC分类号： B82Y30/00 , C07H21/00 , C07K14/003 , Y10S977/704 , Y10S977/728 , Y10S977/734 , Y10S977/753 , Y10S977/792 , Y10S977/80 , Y10S977/906
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2.发明授权Method of identifying a nucleic acid using triple helix formation of adjacently annealed probes 失效一种用于鉴定核酸的方法以形成具有相邻探针三螺旋
公开(公告)号：EP0849363B1
公开(公告)日：2002-10-30
申请号：EP97122242.7
申请日：1997-12-17
申请人： PNA Diagnostics A/S
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6839
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公开(公告)号：EP0815259B1
公开(公告)日：2001-05-23
申请号：EP96906731.3
申请日：1996-03-04
申请人： PNA Diagnostics A/S
发明人： ORUM, Henrik , LESTER, Ane-Ullerup
CPC分类号： C12Q1/6832 , C12Q1/6827 , Y10T436/143333
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公开(公告)号：EP0730602B1
公开(公告)日：1998-08-12
申请号：EP95902082.7
申请日：1994-11-22
申请人： PNA Diagnostics A/S
CPC分类号： C07K14/003 , C07H21/00 , C12Q1/6813
摘要： A nucleic acid analog comprising a polymeric strand which includes a sequence of ligands bound to a backbone made up of linked backbone moieties, which analog is capable of hybridization to a nucleic acid of complementary sequence, further comprising a chelating moiety capable of binding at least one metal ion by chelation.
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公开(公告)号：EP0733206A1
公开(公告)日：1996-09-25
申请号：EP95903781.0
申请日：1994-11-30
申请人： PNA Diagnostics A/S
CPC分类号： G01N33/533 , C07H21/00 , C07K14/003
摘要： A nucleic acid analogue of the PNA type is provided with a kemptide motif and radio-labelled by phosphorylation at a service residue in said motif to provide a radio-labelled nucleic acid analogue having a specific activity in excess of 1 x 105 cpm/νg 32P.
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公开(公告)号：EP0733062A1
公开(公告)日：1996-09-25
申请号：EP95903782.0
申请日：1994-11-30
申请人： PNA Diagnostics A/S
CPC分类号： C07K14/003 , C07H21/00 , C12Q1/6816 , C12Q2525/107 , C12Q2521/319 , C12Q2521/301
摘要： A selected region of a nucleic acid is protected from attack by nuclease by complexing to the nucleic acid a nucleic acid analogue of the PNA type. The surviving sequence may be detected in an assay, optionally after amplification. A PCR reaction may be sterilised and its product assayed by protecting a characterising region of the product by PNA hybridisation followed by nuclease degradation of unprotected nucleic acid.
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公开(公告)号：EP0857791B1
公开(公告)日：2004-03-31
申请号：EP97122253.4
申请日：1997-12-17
申请人： PNA Diagnostics A/S
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6839
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公开(公告)号：EP0925373B1
公开(公告)日：2003-10-22
申请号：EP97938922.8
申请日：1997-08-18
申请人： PNA Diagnostics A/S
发明人： BERGMANN, Frank , HERRMANN, Rupert , KOBOLD, Uwe
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6872 , C12Q1/6827 , Y10T436/143333
摘要： In a process for detecting nucleic acids, a probe P is bonded to a partial sequence S contained in the nucleic acid, producing a bonded product B1, the nucleic acid is decomposed into a bonded product B2 by generating a partial nucleic acid F of defined length and the bonded product B2 or the partial nucleic acid F is detected based on its mass. This process is particularly suitable for detecting in parallel nucleic acids having different sequences.
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公开(公告)号：EP0701627B1
公开(公告)日：1997-01-29
申请号：EP94916331.5
申请日：1994-05-31
申请人： PNA Diagnostics A/S
CPC分类号： C12Q1/6851
摘要： An assay procedure to quantify the amount of starting template in a nucleic acid amplification procedure such as PCR involves trying the amplification in the presence of varying amounts of a nucleic acid analogue which in sufficient quantity will inhibit said amplification procedure by selective interaction with a nucleic acid species present, e.g. a PNA as described in WO-02-20703. The amount of template is given by the amount of nucleic acid analogue critical to cause failure of said amplification procedure.
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公开(公告)号：EP0730602A1
公开(公告)日：1996-09-11
申请号：EP95902082.0
申请日：1994-11-22
申请人： PNA Diagnostics A/S
CPC分类号： C07K14/003 , C07H21/00 , C12Q1/6813
摘要： A nucleic acid analog comprising a polymeric strand which includes a sequence of ligands bound to a backbone made up of linked backbone moieties, which analog is capable of hybridization to a nucleic acid of complementary sequence, further comprising a chelating moiety capable of binding at least one metal ion by chelation.
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