公开(公告)号：EP2203129A4

公开(公告)日：2011-11-23

申请号：EP08838619

申请日：2008-10-14

申请人： UNIV WAKE FOREST HEALTH SCIENCES ,  UNIV WAKE FOREST

发明人： CARROLL DAVID L ,  WAGNER WILLIAM D ,  LEVI NICOLE H ,  ARGENTA LOUIS ,  MORYKWAS MICHAEL

IPC分类号： A61F2/02 ,  A61L27/00

CPC分类号： A61L27/38 ,  C12N5/0629 ,  C12N5/0656 ,  C12N2501/115 ,  C12N2501/165 ,  C12N2501/17 ,  C12N2533/54 ,  C12N2533/74 ,  C12N2535/10

公开(公告)号：EP2461813A4

公开(公告)日：2014-02-19

申请号：EP10807157

申请日：2010-08-05

申请人： UNIV WAKE FOREST HEALTH SCIENCES ,  UNIV WAKE FOREST

发明人： KULIK GEORGE ,  WELKER MARK E ,  SALSBURY JR FREDDIE R

IPC分类号： A61K31/56 ,  A61K31/535 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K31/535 ,  A61K31/56 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/3069 ,  A61K2300/00

公开(公告)号：EP3094347A4

公开(公告)日：2018-04-04

申请号：EP15737898

申请日：2015-01-13

申请人： UNIV WAKE FOREST HEALTH SCIENCES

发明人： LI KING ,  MINTZ AKIVA ,  XIONG XIAOBING ,  JUNG YOUNGKYOO ,  SUN YAO

IPC分类号： A61K39/00 ,  A61K35/28 ,  A61K35/30 ,  A61K35/545 ,  A61K38/18 ,  A61K38/19 ,  A61K41/00 ,  A61K45/06 ,  A61K48/00 ,  A61P35/00 ,  C07H21/04

CPC分类号： A61K48/0083 ,  A61K9/0019 ,  A61K35/28 ,  A61K35/30 ,  A61K35/545 ,  A61K38/1841 ,  A61K38/1866 ,  A61K38/19 ,  A61K38/191 ,  A61K41/0047 ,  A61K45/06 ,  A61K48/005 ,  A61K48/0058 ,  A61K48/0066 ,  A61M37/0092 ,  A61P35/00 ,  C07K14/49 ,  C07K14/495 ,  C07K14/52 ,  C07K14/525 ,  C12N15/86 ,  C12N2830/002

摘要： A method of increasing blood-brain barrier permeability of selected brain tissue in a subject in need thereof is carried out by: (a) parenterally administering to the subject stem cells that migrate to the brain tissue, the stem cells containing a recombinant nucleic acid, the recombinant nucleic acid comprising a nucleic acid encoding a barrier-opening protein or peptide operably associated with a heat-inducible promoter; and then (b) selectively heating the selected brain tissue sufficient to induce the expression of the barrier-opening protein or peptide in an amount effective to increase the permeability of the blood-brain barrier in the selected brain tissue. Nucleic acids, vectors, stem cells and compositions useful for carrying out such methods are also described.

公开(公告)号：EP3294316A2

公开(公告)日：2018-03-21

申请号：EP16790183

申请日：2016-05-06

申请人： H LEE MOFFITT CANCER CENTER AND RES INSTITUTE INC ,  UNIV SOUTH FLORIDA ,  UNIV WAKE FOREST

发明人： MORSE DAVID ,  GILLIES ROBERT ,  MCLAUGHLIN MARK ,  WADAS THADDEUS ,  KIL HYUN JOO ,  TAFRESHI NARGES

IPC分类号： A61K38/08 ,  A61K38/12 ,  A61K45/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K51/088 ,  C07K14/705 ,  G01N33/5743

摘要： The subject matter disclosed herein relates generally to cancer therapy and to anti-cancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents that target MC1R and their use in the treatment of cancer. Methods of screening for MC1R targeted agents are also disclosed.

公开(公告)号：EP3104862A4

公开(公告)日：2017-11-08

申请号：EP15764478

申请日：2015-03-15

申请人： UNIV WAKE FOREST

发明人： BIERBACH ULLRICH ,  PICKARD AMANDA J

IPC分类号： A61K31/555 ,  A61K31/473 ,  C07F15/00

CPC分类号： C07F15/0093 ,  A61K47/545

摘要： wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula I are effective as anti-cancer compounds.

公开(公告)号：EP2897625A4

公开(公告)日：2016-08-17

申请号：EP13834448

申请日：2013-09-10

申请人： UNIV WAKE FOREST HEALTH SCIENCES

发明人： SKARDAL ALEKSANDER ,  ATALA ANTHONY ,  MURPHY SEAN V

IPC分类号： A61L27/36 ,  A61K31/74 ,  A61K35/50 ,  A61L15/40 ,  A61L26/00 ,  A61L27/34 ,  A61L27/48 ,  A61L27/52 ,  C12N5/00

CPC分类号： A61K35/50 ,  A61K47/36 ,  A61K47/42 ,  A61L15/40 ,  A61L26/0057 ,  A61L26/0076 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/52 ,  A61L2430/40 ,  C12N5/0068 ,  C12N2533/92 ,  C08L89/00

摘要： The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.

公开(公告)号：EP2718864A4

公开(公告)日：2016-06-29

申请号：EP12796912

申请日：2012-06-08

申请人： UNIV WAKE FOREST HEALTH SCIENCES

发明人： JOYCE KAREN E ,  LAURIENTI PAUL J ,  HAYASAKA SATORU

IPC分类号： G06N3/02 ,  G06F19/00 ,  G06N3/08 ,  G06N3/12

CPC分类号： G06N3/10 ,  G06N3/126 ,  G16H50/50 ,  Y02A90/26

摘要： An agent-based modeling system for predicting and/or analyzing brain behavior is provided. The system includes a computer processor configured to define nodes and edges that interconnect the nodes. The edges are defined by physiological interactions and/or anatomical connections. The computer processor further defines rules and/or model parameters that define a functional behavior of the nodes and edges. The computer processor assigns the nodes to respective brain regions, and the rules and/or model parameters are defined by observed physiological interaction of the nodes that are functionally and/or structurally connected by said edges of brain regions to thereby provide an agent-based brain model (ABBM) for predicting and/or analyzing brain behavior.

公开(公告)号：EP2765908A4

公开(公告)日：2015-10-07

申请号：EP12839542

申请日：2012-10-10

申请人： UNIV WAKE FOREST HEALTH SCIENCES

发明人： HAMILTON CRAIG ALAN ,  HUNDLEY WILLIAM GREGORY ,  EDWARDS MATTHEW STEVENS ,  ROCCO MICHAEL VITO

IPC分类号： A61B5/026 ,  A61B5/01 ,  A61B5/055 ,  A61B5/145 ,  A61B5/20 ,  G01R33/50 ,  G01R33/56 ,  G01R33/563 ,  G06T7/00

CPC分类号： A61B5/004 ,  A61B5/015 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/201 ,  A61B5/4848 ,  A61B5/4872 ,  A61M5/14 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/5608 ,  G01R33/5635 ,  G01R33/56366

摘要： Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents.

公开(公告)号：EP2629722A4

公开(公告)日：2015-06-17

申请号：EP11835057

申请日：2011-10-19

申请人： UNIV WAKE FOREST HEALTH SCIENCES ,  LUXON EVAN SCOTT

发明人： LUXON EVAN SCOTT ,  WALTER KEITH ANDREW ,  KOMANSKI CHRISTOPHER BLIGH

IPC分类号： A61F9/008 ,  A61F9/013 ,  A61N5/067

CPC分类号： A61F9/00802 ,  A61B34/10 ,  A61B34/25 ,  A61B2034/108 ,  A61F9/00808 ,  A61F2009/00872 ,  A61F2009/00878 ,  A61F2009/00895

摘要： Methods and systems for correcting presbyopia using a surgical excimer laser include activating the laser once and transmitting a pre-defined three dimensional ablation profile to treat presbyopia based on the single activating step.

摘要翻译： 使用外科准分子激光器校正老花眼的方法和系统包括激活激光一次，并且基于单个激活步骤传输预定义的三维消融轮廓以治疗老花眼。

公开(公告)号：EP2542564A4

公开(公告)日：2014-05-07

申请号：EP11751497

申请日：2011-03-07

申请人： UNIV WAKE FOREST HEALTH SCIENCES

发明人： VAN DYKE MARK E ,  SAUL JUSTIN M ,  SMITH THOMAS L ,  DE GUZMAN ROCHE

IPC分类号： C07K1/18 ,  A61F13/00 ,  A61L27/18 ,  A61L27/52 ,  A61L27/54

CPC分类号： C07K14/4741 ,  A61L15/32 ,  A61L15/44 ,  A61L15/60 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/406 ,  A61L2300/414 ,  C08L89/04

摘要： Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of interest (e.g., in vivo or in vitro). In some embodiments, the composition is a composition formulated for controlled release of the compound of interest.

摘要翻译： 本文提供了包括目标化合物的角蛋白组合物（例如，角蛋白凝胶，支架，颗粒等），其用于释放和/或递送目的化合物（例如体内或体外）。 在一些实施方案中，组合物是配制用于感兴趣化合物的受控释放的组合物。