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公开(公告)号：EP2542564A4
公开(公告)日：2014-05-07
申请号：EP11751497
申请日：2011-03-07
CPC分类号： C07K14/4741 , A61L15/32 , A61L15/44 , A61L15/60 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/414 , C08L89/04
摘要： Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of interest (e.g., in vivo or in vitro). In some embodiments, the composition is a composition formulated for controlled release of the compound of interest.
摘要翻译： 本文提供了包括目标化合物的角蛋白组合物（例如，角蛋白凝胶，支架，颗粒等），其用于释放和/或递送目的化合物（例如体内或体外）。 在一些实施方案中，组合物是配制用于感兴趣化合物的受控释放的组合物。
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公开(公告)号：EP1945132A4
公开(公告)日：2011-03-16
申请号：EP06836364
申请日：2006-10-18
发明人： VAN DYKE MARK E
CPC分类号： A61L27/54 , A61L27/425 , A61L27/58 , A61L2300/406 , A61L2430/02
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3.发明公开STRUCTURALLY MODIFIED ACELLULAR TISSUE ENGINEERING SCAFFOLDS AND METHODS OF PRODUCTION 有权结构修饰的脱细胞组织工程支架材料及工艺
公开(公告)号：EP2031968A4
公开(公告)日：2010-12-15
申请号：EP07755875
申请日：2007-04-20
发明人： VAN DYKE MARK E , CHRIST GEORGE , WHITLOCK PATRICK
CPC分类号： A61L27/56 , A61K35/22 , A61K35/30 , A61K35/32 , A61K35/34 , A61K35/39 , A61K35/407 , A61K35/44 , A61L27/3604 , A61L27/3687 , A61L27/38 , A61L2430/40 , C12N5/0068 , C12N2533/90
摘要： Methods are provided for producing a bioscaffold from natural tissues by oxidizing a decellularized tissue to produce a bioscaffold having pores therein. The pore size and porosity is increased to better accommodate intact cells so that live cells can better infiltrate and inhabit the bioscaffold. The bioscaffold may be freeze-dried or lyophilized, sterilized and (optionally) aseptically packaged for subsequent use. A further aspect of the present invention is a bioscaffold produced by the processes described herein. Methods of treatment using the bioscaffold as a graft or as a biomedical implant for implantation are also provided. Also provided are methods of seeding a bioscaffold with mammalian cells, wherein the seeding carried out either in vitro or in vivo, and wherein a bioscaffold produced as described herein is utilized for said seeding.
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4.发明公开KERATIN COMPOSITIONS FOR TREATMENT OF BONE DEFICIENCY OR INJURY 有权KERATINZUSAMMENSETZUNGEN骨缺损或损伤的治疗
公开(公告)号：EP2640408A4
公开(公告)日：2014-06-18
申请号：EP11841674
申请日：2011-11-17
发明人： VAN DYKE MARK E , TELI THALEIA
CPC分类号： A61K38/1748 , A61K35/28 , A61K38/1875 , A61K38/39 , A61K45/06 , A61L27/227 , A61L27/44 , A61L27/54 , A61L2300/406 , A61L2430/02 , A61K2300/00
摘要： A bone graft composition is described, with one or more of: (a) keratose; (b) kerateine; (c) optionally, particulate filler; (d) optionally, an antibiotic; and (e) water or saline. The composition may be provided in sterile form in a container, and optionally lyophilized. Methods of treating a bone deficiency or fracture making use of such compositions are also described.
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5.发明公开COATINGS AND BIOMEDICAL IMPLANTS FORMED FROM KERATIN BIOMATERIALS 有权BESCHICHTUNGEN UND BIOMEDIZINISCHE IMPLANTAA AUS KERATINBIOMATERIALIEN
公开(公告)号：EP1983927A4
公开(公告)日：2010-12-01
申请号：EP07750987
申请日：2007-02-15
发明人： VAN DYKE MARK E
CPC分类号： A61L33/128 , A61K38/1748 , A61L15/32 , A61L26/0047 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/048 , A61L29/085 , A61L29/16 , A61L31/047 , A61L31/10 , A61L31/16 , A61L33/0041 , A61L2300/42 , A61L2300/424 , C07K1/36 , C07K14/4741 , C08L89/04
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6.发明公开
公开(公告)号：EP1991256A4
公开(公告)日：2010-09-15
申请号：EP07751069
申请日：2007-02-16
发明人： VAN DYKE MARK E
CPC分类号： A61L33/128 , A61K38/1748 , A61L15/32 , A61L26/0047 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/048 , A61L29/085 , A61L29/16 , A61L31/047 , A61L31/10 , A61L31/16 , A61L33/0041 , A61L2300/42 , A61L2300/424 , C07K1/36 , C07K14/4741 , C08L89/04
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公开(公告)号：EP1991253A4
公开(公告)日：2010-03-03
申请号：EP07750473
申请日：2007-02-09
发明人： VAN DYKE MARK E
CPC分类号： A61L27/26 , A61K38/185 , A61L27/227 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/32 , A61N1/0551 , Y10S524/916
摘要： A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
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