公开(公告)号：EP1591437B1

公开(公告)日：2009-11-25

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

公开(公告)号：EP1735644A2

公开(公告)日：2006-12-27

申请号：EP05801167.7

申请日：2005-03-31

申请人： The Regents of the University of California, Office of Technology Transfer, University of California

发明人： LO, Yuhwa ,  ZHANG, Deying

IPC分类号： G02B1/06

CPC分类号： G02B26/005 ,  G02B3/14 ,  G02B13/0075 ,  G02B13/009 ,  G02C7/085

摘要： Fluidic adaptive lens devices, and systems employing such lens devices such as eyeglasses and zoom lens systems, along with methods of fabricating and operating such lens devices, are disclosed. In one embodiment, the fluidic lens device includes a first partition that is flexible and optically transparent and a second partition that is coupled to the first partition, where at least a portion of the second partition is optically transparent, and where a first cavity is formed in between the first partition and the second partition. The lens device further includes a first fluidic medium positioned within the cavity, the fluidic medium also being optically transparent, and a first component capable of controlling a parameter of the fluidic medium. When the parameter of the fluidic medium changes, the first partition flexes and an optical property of the lens is varied.

公开(公告)号：EP0954320A1

公开(公告)日：1999-11-10

申请号：EP97942600.0

申请日：1997-09-19

申请人： The Regents of the University of California ,  Inologic, Inc. ,  University Of California

发明人： TRAYNOR-KAPLAN, Alexis ,  SCHULTZ, Carsten ,  ROEMER, Stefan ,  STADLER, Christoph ,  RUDOLF, Marco

IPC分类号： A61K31 ,  A61P1 ,  A61P11 ,  A61P43 ,  C07F9

CPC分类号： A61K31/6615 ,  A61K31/683 ,  C07F9/117

摘要： The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.

公开(公告)号：EP2279199A1

公开(公告)日：2011-02-02

申请号：EP09742207.5

申请日：2009-05-08

申请人： Laakkonen, Pirjo ,  Burnham Institute for Medical Research ,  The Regents Of The University Of California, University of California San Francisco ("UCSF")

发明人： RUOSLAHTI, Erkki ,  BERGERS, Gabriele ,  LAAKKONEN, Pirjo

IPC分类号： C07K7/06 ,  A61K38/08 ,  A61P35/00

CPC分类号： A61K38/10 ,  C07K7/06 ,  G01N33/57407

摘要： The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.

公开(公告)号：EP1906974A2

公开(公告)日：2008-04-09

申请号：EP06800207.0

申请日：2006-07-21

申请人： The Regents of the University of California, Office of Technology Transfer, University of California

发明人： VARKI, Ajit ,  STEVENSON, Jennifer, L.

IPC分类号： A61K31/727 ,  G01N33/567

CPC分类号： G01N33/566 ,  A61K31/727 ,  G01N33/66 ,  G01N33/86 ,  G01N2333/70564 ,  G01N2400/40 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2800/224 ,  A61K2300/00

摘要： The disclosure provides in vitro and in vivo methods for identifying Heparins and Heparinoids that modulate the activity of selectins. The disclosure also provides Heparins and Heparinoids that modulate the activity of selectins. The identification and isolation of these heparin formulations has the potential to mediate a wide variety of pathologies mediated by P- and/or L-selectin, including hematogenous metastasis, diseases associated with inflammation (e.g., asthma, arthritis, allergic dermatitis), ischemia-reperfusion injury, or other pathologies such as sickle cell anemia. Selectin inhibition can be achieved at plasma concentrations lower than those that cause excessive anticoagulation or unwanted bleeding in a human subject.

公开(公告)号：EP1651241A2

公开(公告)日：2006-05-03

申请号：EP04779183.5

申请日：2004-07-27

申请人： The Regents of the University of California, Office of Technology Transfer, University of California

发明人： JACOBS, R., Dept. Ecology, Evolution&Marine Biolgy ,  MYDLARZ, L., Dept. of Ecology & Evol. Biology ,  MOYA, C., Dept. Ecology, Evolution & Marine Biolgy

IPC分类号： A61K31/70 ,  C07H15/24

CPC分类号： A61K31/704 ,  A61K31/70 ,  A61K2300/00

摘要： Disclosed herein are methods for treating, preventing, or inhibiting injuries, methods for inducing, increasing, or modulating calcium mobilization, methods for preventing, inhibiting, decreasing, or modulating phagocytosis, and treating, preventing, or inhibiting diseases and disorders associated with calcium mobilization and phagocytosis. These methods comprise the administration of at least one pseudopterosin compound.

公开(公告)号：EP1591437A2

公开(公告)日：2005-11-02

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

摘要： A compound having the following chemical structure:
its produg esters and acid-addition salts, useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, wherein R groups are defined in the claims.

公开(公告)号：EP1591437A3

公开(公告)日：2006-03-08

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

摘要： A compound having the following chemical structure:

its produg esters and acid-addition salts, useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, wherein R groups are defined in the claims.

摘要翻译： 具有以下化学结构的化合物：其produg酯和酸加成盐，如白介素-1和肿瘤坏死因子±调制器是有用的，worin R基团中的权利要求限定。

公开(公告)号：EP4457211A2

公开(公告)日：2024-11-06

申请号：EP22917308.3

申请日：2022-12-28

申请人： The Regents of the University of California

发明人： DOHIL, Ranjan ,  BALLATORE, Carlo

IPC分类号： C07C323/50 ,  A61K31/105 ,  A61P1/16

公开(公告)号：EP4455301A2

公开(公告)日：2024-10-30

申请号：EP24200492.7

申请日：2018-02-23

申请人： The Regents of The University of California

发明人： DI CARLO, Dino ,  WU, Chueh-Yu

IPC分类号： C12Q1/6804

摘要： The invention is directed to a particle system comprising a plurality of three-dimensional particles, each particle having an interior region defining a three-dimensional cavity or void and an exterior region, wherein the cavity or void is open to an external environment of the three-dimensional particle and wherein the cavity or void has a volume between about 1 pL and about 125 nL and a molecular capture region disposed on the interior region of the particles configured to capture cells, and to a method of performing an assay using the particle system.