公开(公告)号：EP4406935A1

公开(公告)日：2024-07-31

申请号：EP22872031.4

申请日：2022-09-21

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： NAN, Fajun ,  LI, Jingya ,  CHEN, Yi ,  SONG, Gaolei ,  XIE, Zhifu ,  FANG, Yanfen ,  ZHANG, Mei ,  SUN, Xinyu ,  CAO, Lei ,  MA, Hui ,  YANG, Yurou

IPC分类号： C07C57/13 ,  C07C57/42 ,  C07C61/35 ,  C07C55/28 ,  A61P3/10 ,  A61P3/04 ,  A61P35/00 ,  A61K31/194

CPC分类号： A61K31/201 ,  A61K31/225 ,  A61K31/194 ,  A61K31/496 ,  A61K38/05 ,  A61P1/16 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P35/00 ,  A61P35/02 ,  C07C55/28 ,  C07C57/13 ,  C07C57/42 ,  C07C61/35 ,  C07C69/74 ,  C07D401/14 ,  C07K5/06017

摘要： A long-chain compound, a preparation method therefor and the use thereof are disclosed. The structure of said compound is represented by formula (I). The definition of each substituent in the formula is as set out in the description and claims. The compound of the present invention can directly inhibit ACLY, inhibit lipid synthesis in primary hepatocytes, inhibit lipid de novo synthesis and histone acetylation in various cancer cells such as H358, and inhibit cancer cell proliferation. The compound may be used to prepare drugs that treat metabolic diseases such as hyperlipidemia and atherosclerosis or various cancers such as lung cancer, pancreatic cancer, breast cancer, ovarian cancer, liver cancer, intestinal cancer, brain cancer, and acute myeloid leukemia.

公开(公告)号：EP1301458B1

公开(公告)日：2015-09-09

申请号：EP01950437.2

申请日：2001-06-25

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： GRUBBS, Robert, H. ,  CHATTERJEE, Arnab, K. ,  MORGAN, John, P. ,  SCHOLL, Matthias ,  CHOI, Tae-Lim

IPC分类号： C07C317/14 ,  C07C233/09 ,  C07C205/06 ,  C07C61/35 ,  C07D323/02 ,  C07D263/04 ,  C07D303/04 ,  C07D309/18 ,  C07F7/04 ,  C07B37/00 ,  C07C45/67 ,  C07C45/69 ,  C07C45/72 ,  C07C67/293 ,  C07C67/343 ,  C07C231/12 ,  C07C259/06 ,  C07C315/04 ,  C07D303/22 ,  C07C309/12 ,  C07D315/00 ,  C07D317/12 ,  C07D319/12 ,  C07D321/08 ,  C07D263/22 ,  C07D309/30 ,  C07D319/14

CPC分类号： C07D303/22 ,  C07B37/00 ,  C07C45/673 ,  C07C45/69 ,  C07C45/72 ,  C07C67/293 ,  C07C67/343 ,  C07C201/12 ,  C07C231/12 ,  C07C259/06 ,  C07C315/04 ,  C07D263/22 ,  C07D263/24 ,  C07D309/12 ,  C07D309/30 ,  C07D315/00 ,  C07D317/12 ,  C07D319/12 ,  C07D319/14 ,  C07D321/08 ,  C07D413/12 ,  C07C49/597 ,  C07C317/14 ,  C07C233/09 ,  C07C233/11 ,  C07C205/06 ,  C07C205/56

公开(公告)号：EP1695956A4

公开(公告)日：2007-09-12

申请号：EP04819462

申请日：2004-11-26

申请人： CHUGOKU MARINE PAINTS

发明人： NISHIGUCHI TAKAHIRO ,  NAKAMURA NAOYA ,  TSUBOI MAKOTO

IPC分类号： C07C61/22 ,  A01K75/00 ,  B63B59/04 ,  C07C51/353 ,  C07C61/29 ,  C07C61/35 ,  C07C67/347 ,  C07C69/75 ,  C09D5/16 ,  C09D7/12 ,  C09D133/02 ,  C09D135/00 ,  C09D143/04 ,  E02D29/09

CPC分类号： C07C403/02 ,  C07C61/22 ,  C07C61/29 ,  C07C61/35 ,  C07C69/75 ,  C07C2601/16 ,  C07C2602/44 ,  C09D5/1662

摘要： [MEANS FOR SOLVING PROBLEMS] A novel cyclic carboxylic acid formed by the addition reaction of an unsaturated carboxylic acid with a conjugated diene compound; a metal salt of the acid; a compounding agent (A) for antifouling coating compositions which comprises at least one of the novel cyclic carboxylic acid, derivatives of the cyclic carboxylic acid (excluding the metal salts), metal salts of the cyclic carboxylic acid, and metal salts of the cyclic carboxylic acid derivatives; and an antifouling coating composition comprising the compounding agent (A) and a copolymer (B) for self-polishing type antifouling coating compositions. [EFFECTS] The composition can form an antifouling coating film which is reduced in environmental burden, evenly wears at a given rate over long, and can retain excellent antifouling performance over long. It is applicable also to ships and other objects for use in highly fouling waters.

公开(公告)号：EP1178952B1

公开(公告)日：2007-08-22

申请号：EP00932408.8

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California

发明人： PALLADINO, Michael ,  THEODORAKIS, Emmanuel, A.

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

摘要： Compounds are disclosed that have the chemical structure of Formula (II) and (IIB) and their produg esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the treatment of various diseases, wherein the R groups are defined in the claims.

公开(公告)号：EP1301458A4

公开(公告)日：2006-11-02

申请号：EP01950437

申请日：2001-06-25

申请人： CALIFORNIA INST OF TECHN

发明人： GRUBBS ROBERT H ,  CHATTERJEE ARNAB K ,  MORGAN JOHN P ,  SCHOLL MATTHIAS ,  CHOI TAE-LIM

IPC分类号： B01J31/22 ,  C07B37/00 ,  C07B37/04 ,  C07B61/00 ,  C07C45/67 ,  C07C45/69 ,  C07C45/72 ,  C07C49/597 ,  C07C57/26 ,  C07C67/293 ,  C07C67/313 ,  C07C67/333 ,  C07C67/343 ,  C07C69/145 ,  C07C69/24 ,  C07C69/533 ,  C07C69/608 ,  C07C69/618 ,  C07C69/67 ,  C07C69/73 ,  C07C69/738 ,  C07C69/767 ,  C07C201/12 ,  C07C205/06 ,  C07C205/56 ,  C07C231/12 ,  C07C233/09 ,  C07C233/11 ,  C07C259/06 ,  C07C315/04 ,  C07C317/14 ,  C07D203/10 ,  C07D263/22 ,  C07D263/24 ,  C07D303/22 ,  C07D309/12 ,  C07D309/30 ,  C07D309/32 ,  C07D315/00 ,  C07D317/12 ,  C07D319/12 ,  C07D319/14 ,  C07D321/08 ,  C07D413/12 ,  C07F7/18 ,  C07C61/35 ,  C07C309/12 ,  C07D263/04 ,  C07D303/04 ,  C07D309/18 ,  C07D323/02 ,  C07F7/04

CPC分类号： C07D303/22 ,  C07B37/00 ,  C07C45/673 ,  C07C45/69 ,  C07C45/72 ,  C07C67/293 ,  C07C67/343 ,  C07C201/12 ,  C07C231/12 ,  C07C259/06 ,  C07C315/04 ,  C07D263/22 ,  C07D263/24 ,  C07D309/12 ,  C07D309/30 ,  C07D315/00 ,  C07D317/12 ,  C07D319/12 ,  C07D319/14 ,  C07D321/08 ,  C07D413/12 ,  C07C49/597 ,  C07C317/14 ,  C07C233/09 ,  C07C233/11 ,  C07C205/06 ,  C07C205/56

摘要： The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of α-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of general formula (I) or (II), wherein: M is ruthenium or osmium; X and X1 are each independently an anionic ligand; L is a neutral electron donor ligand; and, R, R?1, R6, R7, R8, and R9¿ are each independently hydrogen or a substituent selected from the group consisting of C¿1?-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl.

公开(公告)号：EP1591437A3

公开(公告)日：2006-03-08

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26

摘要： A compound having the following chemical structure:

its produg esters and acid-addition salts, useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, wherein R groups are defined in the claims.

摘要翻译： 具有以下化学结构的化合物：其produg酯和酸加成盐，如白介素-1和肿瘤坏死因子±调制器是有用的，worin R基团中的权利要求限定。

公开(公告)号：EP1056709A1

公开(公告)日：2000-12-06

申请号：EP99903593.4

申请日：1999-02-15

申请人： CHEMINOVA AGRO A/S

发明人： KLEMMENSEN, Per, Dausell ,  KOLIND-ANDERSEN, Hans ,  WINCKELMANN, Ib

IPC分类号： C07C61/35

CPC分类号： C07C51/377 ,  C07C61/35

摘要： Preparation of cyclopropane carboxylic acids usable as intermediates and of formula (II), wherein R1 represents halogen, preferably Cl or Br, or haloalkyl, preferably CF3, and X2 represents halogen, preferably Cl or Br, where R1 and X2 may be the same or different, and wherein the configuration of (II) is predominantly Z for R1 = CF3 and X2 = Cl; by reacting, in the presence of a catalyst, a compound of formula (I), wherein R1 and X2 are as defined, and X1 represents halogen, preferably Cl or Br, where R1, X1 and X2 may be the same or different, with a compound which is a hydrogen donor.

公开(公告)号：EP0061880B1

公开(公告)日：1985-06-19

申请号：EP82301469.1

申请日：1982-03-22

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Suzukamo, Gohfu ,  Fukao, Masami

IPC分类号： C07C51/487 ,  C07C61/35 ,  C07C61/37 ,  C07C61/40 ,  C07C51/56

CPC分类号： C07C51/487 ,  C07C61/37 ,  C07C61/35

公开(公告)号：EP0010874B1

公开(公告)日：1983-06-22

申请号：EP79302090.0

申请日：1979-10-03

申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

发明人： Leigh, Thomas

IPC分类号： C07B19/00 ,  C07C61/40 ,  C07C61/35 ,  C07C61/15 ,  C07C61/04 ,  C07C87/28

CPC分类号： C07C61/40 ,  C07C51/487 ,  Y02P20/582

公开(公告)号：EP1591437B1

公开(公告)日：2009-11-25

申请号：EP05076500.7

申请日：2000-05-12

申请人： Nereus Pharmaceuticals, Inc. ,  The Regents of the University of California, Office of Technology Transfer, University of California

发明人： Palladino, Michael ,  Theodorakis, Emmanuel, A

IPC分类号： C07C61/35 ,  C07C61/29 ,  C07C69/753 ,  C07C69/757 ,  C07C69/007 ,  C07C69/00 ,  C07C33/14 ,  C07C13/60 ,  A61K31/22 ,  A61K31/215 ,  A61K31/19 ,  A61K31/045 ,  A61K31/015

CPC分类号： C07C62/32 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  C07B2200/05 ,  C07C61/29 ,  C07C61/35 ,  C07C69/753 ,  C07C2603/26