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    Bifunctional chelating agents
    3.
    发明公开
    Bifunctional chelating agents 失效
    Bifunktionelle chelatbildende Agenzien。

    公开(公告)号：EP0279307A2

    公开(公告)日：1988-08-24

    申请号：EP88101776.8

    申请日：1988-02-08

    Applicant: ABBOTT LABORATORIES

    Inventor： Johnson, David K. ,  Kline, Steven J.

    IPC: C07C229/36 ,  C07C331/28 ,  C07C335/16 ,  A61K49/02

    CPC classification number: C07C275/42 ,  A61K47/50 ,  C07C335/22

    Abstract: The present invention provides bifunctional chelating agents comprising a unique substrate reactive moiety incorporated into a carboxymethyl arm of a polyaminopolycarboxylate chelating framework capable of forming stable complexes with metal ions.

    Abstract translation: 本发明提供了双功能螯合剂，其包含结合到能与金属离子形成稳定的络合物的聚氨基多羧酸盐螯合骨架的羧甲基臂的独特的底物反应性部分。

    Ion-capture assays and devices
    6.
    发明公开
    Ion-capture assays and devices 失效
    Ionenfang-Teste und -Vorrichtungen。

    公开(公告)号：EP0326100A2

    公开(公告)日：1989-08-02

    申请号：EP89101263.5

    申请日：1989-01-25

    Applicant: ABBOTT LABORATORIES

    Inventor： Hiltibran, Robert G. ,  Jou, Yi-Her ,  Kline, Steven J. ,  Schultz, Steven George ,  Stroupe, Stephen Denham

    IPC: G01N33/537 ,  G01N33/543 ,  G01N33/538

    CPC classification number: G01N33/538 ,  G01N33/54366 ,  G01N33/57473

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-­specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

    Abstract translation: 本发明提出了新的分离和测定方法，其允许指示剂和捕获试剂在溶液中以避免减慢的免疫反应动力学的问题。 分离过程包括与带电物质结合的分析物特异性可溶性捕获试剂和相反带电的不溶性固相材料。 将疑似含有分析物的流体样品与捕获试剂在溶液中混合以形成带电的捕获试剂/分析物复合物。 当结合完成时，溶液与相反电荷的固相材料接触以吸引，附着和从流体样品中分离捕获试剂/分析物复合物。 使用合适的指示剂，即与能够产生可检测信号的标签缀合的第二分析物特异性结合物质，可以进行夹心和竞争性测定。 通过与相反电荷的固相材料接触可以将测定反应复合物与溶液分离，并通过检测指示剂试剂的标记来监测分析物的存在或量。

    Ion-capture assays and devices
    8.
    发明公开
    Ion-capture assays and devices 失效
    离子测定和装置

    公开(公告)号：EP0326100A3

    公开(公告)日：1990-11-07

    申请号：EP89101263.5

    申请日：1989-01-25

    Applicant: ABBOTT LABORATORIES

    Inventor： Hiltibran, Robert G. ,  Jou, Yi-Her ,  Kline, Steven J. ,  Schultz, Steven George ,  Stroupe, Stephen Denham

    IPC: G01N33/537 ,  G01N33/543 ,  G01N33/538

    CPC classification number: G01N33/538 ,  G01N33/54366 ,  G01N33/57473

    Abstract: This invention presents novel separation and assay procedures which allows both the indicator and the capture reagents to be in solution to avoid problems of slowed immunoreaction kinetics. The separation procedure involves an analyte-specific soluble capture reagent, that is conjugated to a charged substance, and an insoluble solid phase material that is oppositely charged. A fluid sample suspected of containing the analyte is mixed with the capture reagent in solution to form a charged capture reagent/analyte complex. When binding is complete, the solution is contacted to the oppositely charged solid phase material to attract, attach, and separate the capture reagent/analyte complex from the fluid sample. With the appropriate indicator reagent, i.e., a second analyte-­specific binding substance which is conjugated to a label capable of producing a detectable signal, both sandwich and competitive assays can be performed. The assay reaction complex can be separated from the solution by contact with the oppositely charged solid phase material, and the presence or amount of analyte is monitored by detecting the label of the indicator reagent.

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