公开(公告)号：EP0805812B1

公开(公告)日：2001-06-13

申请号：EP96903364.6

申请日：1996-01-11

申请人： Abbott Laboratories

发明人： MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  PRATT, John, K. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  YAMAMOTO, Diane, M.

IPC分类号： C07D487/02 ,  A61K31/505 ,  C07D495/02 ,  C07D475/02 ,  C07D487/00

CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.

公开(公告)号：EP0808318B1

公开(公告)日：2000-06-28

申请号：EP96903340.6

申请日：1996-01-11

申请人： Abbott Laboratories

发明人： MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  ELMORE, Steven, W. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  WENDT, Michael, D. ,  YAMAMOTO, Diane, M.

IPC分类号： C07D495/04 ,  C07D491/048 ,  C07D487/04 ,  C07D403/06 ,  C07D491/147 ,  C07D495/14 ,  C07D487/16 ,  C07D471/14 ,  A61K31/395

CPC分类号： C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/04 ,  C07D495/14

摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.

公开(公告)号：EP0942911B1

公开(公告)日：2001-10-17

申请号：EP97951555.8

申请日：1997-12-04

申请人： Abbott Laboratories

发明人： MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F. ,  WENDT, Michael, D. ,  HAIGHT, Anthony, R. ,  ZHANG, Weijiang

IPC分类号： C07D491/04 ,  A61K31/415

CPC分类号： C07D491/04

摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 adrenoreceptors and treating BPH.

公开(公告)号：EP0805812A1

公开(公告)日：1997-11-12

申请号：EP96903364.0

申请日：1996-01-11

申请人： Abbott Laboratories

发明人： MEYER, Michael, D. ,  ALTENBACH, Robert, J. ,  BASHA, Fatima, Z. ,  CARROLL, William, A. ,  DRIZIN, Irene ,  KERWIN, James, F., Jr. ,  LEBOLD, Suzanne, A. ,  LEE, Edmund, L. ,  PRATT, John, K. ,  SIPPY, Kevin, B. ,  TIETJE, Karin, R. ,  YAMAMOTO, Diane, M.

IPC分类号： A61K31 ,  A61P13 ,  A61P15 ,  A61P25 ,  C07D401 ,  C07D403 ,  C07D471 ,  C07D473 ,  C07D475 ,  C07D487 ,  C07D491 ,  C07D495 ,  C07D498

CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.

公开(公告)号：EP1976514A2

公开(公告)日：2008-10-08

申请号：EP07718092.5

申请日：2007-01-17

申请人： ABBOTT LABORATORIES

发明人： VERLINDEN, Marleen ,  MEYER, Michael, D. ,  DECKER, Michael, W. ,  SULLIVAN, James, P. ,  BUNNELLE, William, H.

IPC分类号： A61K31/40 ,  A61K31/435 ,  A61P25/28

CPC分类号： A61K31/40 ,  A61K31/435 ,  A61K31/4439 ,  G01N33/944 ,  G01N2500/00

摘要： The invention relates to neuronal nicotinic receptor ligands, methods of identifying such ligands for neuronal nicotinic receptor modulation, particularly such ligands demonstrating beneficial side effect tolerability, and methods of using such neuronal nicotinic receptor ligands to provide pharmaceutical compositions and products.

公开(公告)号：EP1102754A1

公开(公告)日：2001-05-30

申请号：EP99939019.8

申请日：1999-08-06

申请人： ABBOTT LABORATORIES

发明人： ALTENBACH, Robert, J. ,  MEYER, Michael, D. ,  KERWIN, James, F., Jr. ,  HOLLADAY, Mark, W. ,  KHILEVICH, Albert ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey ,  CARROLL, William, A.

IPC分类号： C07D233/61 ,  A61K31/4164 ,  C07D405/04 ,  C07D413/12 ,  C07D409/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D405/12 ,  C07D277/28 ,  C07D263/32 ,  C07D263/48 ,  C07D277/40

CPC分类号： C07D233/64 ,  C07D233/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D409/12 ,  C07D417/12

摘要： Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with α1A agonists. Also disclosed are α1A agonist compositions and a method of activating α1 adrenoceptors in a mammal.

公开(公告)号：EP1147112A1

公开(公告)日：2001-10-24

申请号：EP00906998.0

申请日：2000-01-25

申请人： ABBOTT LABORATORIES

发明人： BUNNELLE, William, H. ,  CRISTINA, Daniela, Barlocco ,  DAANEN, Jerome, F. ,  DART, Michael, J. ,  MEYER, Michael, D. ,  RYTHER, Keith, B. ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  TOUPENCE, Richard, B.

IPC分类号： C07D487/08 ,  A61K31/395 ,  A61P25/00 ,  C07D471/08 ,  C07D519/00

CPC分类号： C07D471/08 ,  C07D401/08 ,  C07D487/08

摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：EP1095044A1

公开(公告)日：2001-05-02

申请号：EP99933919.5

申请日：1999-07-12

申请人： ABBOTT LABORATORIES

发明人： MEYER, Michael, D. ,  CARROLL, William, A.

IPC分类号： C07D495/04 ,  A61K31/519 ,  C07D491/048 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Compounds of Formula (I) and their pharmaceutically acceptable salts, esters and prodrugs thereof are selective alpha-1D adrenoceptor antagonists and may be useful for treating disease states wherein R2 is (a).

公开(公告)号：EP0422134A1

公开(公告)日：1991-04-17

申请号：EP90900592.0

申请日：1989-12-07

申请人： ABBOTT LABORATORIES

发明人： DeBERNARDIS, John, F. ,  MEYER, Michael, D. ,  SIPPY, Kevin, B.

IPC分类号： C07D209 ,  A61K31 ,  A61P9 ,  A61P25 ,  A61P43 ,  C07D221 ,  C07D223 ,  C07D403 ,  C07D405 ,  C07D417 ,  C07D491

CPC分类号： C07D405/06 ,  C07D209/62 ,  C07D209/70 ,  C07D221/16 ,  C07D417/06

摘要： Des 8-alkoxy-1,2,3,3a,8,8a-hexahydroindéno[1,2-c]pyrroles substitués; des 5-alkoxy-2,3,4,4a,9,9a-hexahydro-1H-indéno[2,1-c]pyridines; et des 9-alkoxy-2,3,3a,4,5,9a-hexahydro-1H-benz[e]isoindoles sont des agents récepteurs sélectifs de 5-HT, utiles notamment pour le traitement de l'angoisse, la dépression et l'hypertension.

公开(公告)号：EP1833824A1

公开(公告)日：2007-09-19

申请号：EP05855099.7

申请日：2005-12-21

申请人： ABBOTT LABORATORIES

发明人： PACE, Jennifer, M. ,  TIETJE, Karin ,  DART, Michael, J. ,  MEYER, Michael, D.

IPC分类号： C07D417/06 ,  C07D413/06 ,  C07D409/06 ,  C07D405/06 ,  C07D401/06 ,  A61K31/404 ,  A61K31/55 ,  A61K31/496 ,  A61K31/454 ,  A61K31/435 ,  A61K31/428 ,  A61K31/422

CPC分类号： C07D403/06 ,  C07D209/12 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention provides novel compounds of Formula (I), which are CB2 selective ligands useful for the treatment of pain.

摘要翻译： 本发明提供了式（I）的新型化合物，它们是用于治疗疼痛的CB 2选择性配体。