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1.发明公开SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开取代二氮杂如α-7烟碱型乙酰胆碱受体的配体
公开(公告)号：EP1664045A1
公开(公告)日：2006-06-07
申请号：EP04784568.0
申请日：2004-09-17
申请人： ABBOTT LABORATORIES
发明人： BASHA, Anwer , BUNNELLE, William, H. , DART, Michael, J. , GALLAGHER, Megan, E. , JI, Jianguo , PACE, Jennifer, M. , RYTHER, Keith, B. , TIETJE, Karin, R. , MORTELL, Kathleen, H. , NERSESIAN, Diana, L. , SCHRIMPF, Michael, R. , LI, Tao
IPC分类号： C07D471/04 , C07D487/04 , C07D487/08 , C07D471/08 , A61K31/435 , A61P25/00
CPC分类号： C07D487/08 , C07D471/04 , C07D471/08 , C07D487/04
摘要： Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
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公开(公告)号：EP1539733A2
公开(公告)日：2005-06-15
申请号：EP03770235.4
申请日：2003-08-13
申请人： Abbott Laboratories
IPC分类号： C07D401/04 , C07D417/04 , C07D403/04 , C07D471/04 , C07D495/04 , C07D409/04 , A61K31/4439 , A61K31/422 , A61K31/433 , A61K31/427 , A61K31/4178 , A61K31/437 , A61K31/4365 , A61K31/4025
CPC分类号： C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D495/04
摘要： Compounds of formula (I), are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.
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3.发明公开BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 失效双环取代的六氢苯并（E）与α-1肾上腺素能拮抗剂活性的异吲哚
公开(公告)号：EP0805812A1
公开(公告)日：1997-11-12
申请号：EP96903364.0
申请日：1996-01-11
申请人： Abbott Laboratories
发明人： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC分类号： A61K31 , A61P13 , A61P15 , A61P25 , C07D401 , C07D403 , C07D471 , C07D473 , C07D475 , C07D487 , C07D491 , C07D495 , C07D498
CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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4.发明公开TRICYCLIC SUBSTITUTED HEXAHYDROBENZ E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 失效三环取代六氢苯并（E）异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：EP0808318A1
公开(公告)日：1997-11-26
申请号：EP96903340.0
申请日：1996-01-11
申请人： Abbott Laboratories
发明人： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
CPC分类号： C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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5.发明公开TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS 失效三级和二级胺作为ALPHA-2拮抗剂和血清素录音抑制剂。
公开(公告)号：EP0646112A1
公开(公告)日：1995-04-05
申请号：EP93901313.0
申请日：1992-12-14
申请人： ABBOTT LABORATORIES
发明人： MEYER, Michael, D. , DeBERNARDIS, John, F. , PRASAD, Rajnandan , SIPPY, Kevin, B. , TIETJE, Karin, R.
IPC分类号： C07D317 , A61K31 , A61P9 , A61P25 , A61P27 , A61P43 , C07C217 , C07D209 , C07D215 , C07D217 , C07D231 , C07D235 , C07D241 , C07D263 , C07D265 , C07D271 , C07D275 , C07D277 , C07D279 , C07D285 , C07D307 , C07D311 , C07D319 , C07D327 , C07D333 , C07D335 , C07D405 , C07D407 , C07D409 , C07D413 , C07D417
CPC分类号： C07D209/48 , C07C217/74 , C07C2602/10 , C07D209/08 , C07D209/14 , C07D209/44 , C07D215/12 , C07D217/02 , C07D235/06 , C07D241/42 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D307/79 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
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公开(公告)号：EP1284976A2
公开(公告)日：2003-02-26
申请号：EP01944118.7
申请日：2001-04-27
申请人： Abbott Laboratories
发明人： SCHRIMPF, Michael, R. , TIETJE, Karin, R. , TOUPENCE, Richard, B. , JI, Jianguo , BASHA, Anwer , BUNNELLE, William, H. , DAANEN, Jerome, F. , PACE, Jennifer, M. , SIPPY, Kevin, B.
IPC分类号： C07D487/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals (nicotinic acetylcholine receptor ligands).
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7.发明授权BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 失效双环取代的六氢苯并（E）与α-1肾上腺素能拮抗剂活性的异吲哚
公开(公告)号：EP0805812B1
公开(公告)日：2001-06-13
申请号：EP96903364.6
申请日：1996-01-11
申请人： Abbott Laboratories
发明人： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC分类号： C07D487/02 , A61K31/505 , C07D495/02 , C07D475/02 , C07D487/00
CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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8.发明授权TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 失效三环取代六氢苯并[E]异吲哚ALPHA-1肾上腺素能受体拮抗剂
公开(公告)号：EP0808318B1
公开(公告)日：2000-06-28
申请号：EP96903340.6
申请日：1996-01-11
申请人： Abbott Laboratories
发明人： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
IPC分类号： C07D495/04 , C07D491/048 , C07D487/04 , C07D403/06 , C07D491/147 , C07D495/14 , C07D487/16 , C07D471/14 , A61K31/395
CPC分类号： C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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