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公开(公告)号：EP1740579A1
公开(公告)日：2007-01-10
申请号：EP05742125.7
申请日：2005-03-24
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要： Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：EP1740579B1
公开(公告)日：2015-08-19
申请号：EP05742125.7
申请日：2005-03-24
申请人： AbbVie Inc. , Makoto, Aoyama
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
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公开(公告)号：EP2056869A2
公开(公告)日：2009-05-13
申请号：EP07811045.9
申请日：2007-08-03
申请人： ABBOTT LABORATORIES
IPC分类号： A61K39/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在预防和/或治疗急性和慢性炎症和其他疾病中的用途。
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公开(公告)号：EP2064336A2
公开(公告)日：2009-06-03
申请号：EP07873427.4
申请日：2007-09-07
申请人： ABBOTT LABORATORIES
发明人： WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
CPC分类号： A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
摘要翻译： 本发明包括IL-13结合蛋白。 具体地，本发明涉及嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hIL-13活性有害的病症的人类受试者中。
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公开(公告)号：EP1928237A2
公开(公告)日：2008-06-11
申请号：EP06824879.8
申请日：2006-09-01
申请人： ABBOTT LABORATORIES
发明人： BRIENLINGER, Eric, C. , CALDERWOOD, David, J. , FRANK, Kristine, E. , BETSCHMANN, Patrick , HIRST, Gavin, C. , MORYTKO, Michael, J. , DIXON, Richard, W.
IPC分类号： A01N43/50
CPC分类号： C07D487/04
摘要： The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I), wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
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公开(公告)号：EP1928506A2
公开(公告)日：2008-06-11
申请号：EP06813554.0
申请日：2006-08-18
申请人： ABBOTT LABORATORIES
IPC分类号： A61K49/00 , A61K39/395 , A61K31/60 , A61K31/551 , A61K31/496 , A61K31/445 , A61K31/4152 , A61K31/365 , A61K31/343 , A61K31/192
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/244 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/64 , C07K2317/94 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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