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公开(公告)号：EP1740579B1
公开(公告)日：2015-08-19
申请号：EP05742125.7
申请日：2005-03-24
申请人： AbbVie Inc. , Makoto, Aoyama
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
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公开(公告)号：EP1740579A1
公开(公告)日：2007-01-10
申请号：EP05742125.7
申请日：2005-03-24
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要： Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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3.发明授权
公开(公告)号：EP2970215B1
公开(公告)日：2019-04-17
申请号：EP14710280.0
申请日：2014-03-14
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying X. , ZHAO, Hongyu H. , LI, Huan-Qiu , BREWER, Jason T. , ZANZE, Irini , DIETRICH, Justin , VASUDEVAN, Anil , DJURIC, Stevan, W. , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D207/48 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61P25/00
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公开(公告)号：EP2560973A1
公开(公告)日：2013-02-27
申请号：EP10850401.0
申请日：2010-10-21
申请人： Abbvie Inc.
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , C07D471/14 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/04 , C07D498/04 , Y02E60/321
摘要： The present application relates to 1,2,3,4)4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H- pyrido[3,4- d (][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H- pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-6] [1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
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5.发明公开PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开吡咯烷，药物组合物ORDER及其在治疗中
公开(公告)号：EP2970215A1
公开(公告)日：2016-01-20
申请号：EP14710280.0
申请日：2014-03-14
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying X. , ZHAO, Hongyu H. , LI, Huan-Qiu , BREWER, Jason T. , ZANZE, Irini , DIETRICH, Justin , VASUDEVAN, Anil , DJURIC, Stevan, W. , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D207/48 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/12 , C07D207/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to pyrrolidine derivatives of formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
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公开(公告)号：EP3150607A1
公开(公告)日：2017-04-05
申请号：EP16195747.7
申请日：2010-10-21
申请人： AbbVie Inc.
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , C07D471/14 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/04 , C07D498/04 , Y02E60/321
摘要： The present application relates to 1,2,3,4)4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H- pyrido[3,4- d (][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H- pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-6] [1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及到1,2,3,4）5,6,7-八氢吡嗪并[1,2-α] [1,4]苯并二氮杂，-1,2,3，5,6-， 7-八氢吡嗪并[1）2-] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b八氢-1H-吡啶并[3,4-D（] [2] 苯并吖庚因，甲基-1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-α] [1]苯并吖庚因-1,2,3，5-六氢 - 7 H吡嗪并[ 1,2-α] [4,1] benzoxazepines，和2,3,4,4a，5,6-六氢-1 H-吡嗪并[2,1-D] [1,5] benzoxazepines，和5.6 ，7,7A，8,9,10,11-八氢吡嗪并[1,2-D]吡啶并[3.2-6] [1,4]式的二氮杂衍生物（I）worin R 1，R 2，R 3 中，R 4，R 5，R 6，X 1，X 2，X 3，X 4，Y 1，Y 2，和Y 3如说明书中所定义。因此，本申请涉及组合物，其包括测试的化合物，和 使用测试化合物和组合物，和方法鉴定测试的化合物治疗的疾病病症的方法。
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公开(公告)号：EP2560973B1
公开(公告)日：2016-11-16
申请号：EP10850401.0
申请日：2010-10-21
申请人： Abbvie Inc.
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , C07D471/14 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/04 , C07D498/04 , Y02E60/321
摘要： The present application relates to 1,2,3,4)4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H- pyrido[3,4- d (][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H- pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-6] [1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
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公开(公告)号：EP2421870B1
公开(公告)日：2016-03-09
申请号：EP10716195.2
申请日：2010-04-22
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/00
CPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04
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