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公开(公告)号：EP1740579A1
公开(公告)日：2007-01-10
申请号：EP05742125.7
申请日：2005-03-24
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要： Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：EP1740579B1
公开(公告)日：2015-08-19
申请号：EP05742125.7
申请日：2005-03-24
申请人： AbbVie Inc. , Makoto, Aoyama
发明人： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
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公开(公告)号：EP2421870A2
公开(公告)日：2012-02-29
申请号：EP10716195.2
申请日：2010-04-22
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/00
CPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/04
摘要： The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-
a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-
a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1
H -pyrido[3,4-
d ][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-
a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7
H -pyrazino[1,2-
a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1
H -pyrazino[2,1-
d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-
d ]pyrido[3,2-
b ][1,4]diazepine derivatives of formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , X
1 , X
2 , X
3 , X
4 , Y
1 , Y
2 , and Y
3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.-
公开(公告)号：EP2432783A1
公开(公告)日：2012-03-28
申请号：EP10720502.3
申请日：2010-05-20
发明人： WELCH, Dennie, S. , AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan, W. , WILSON, Noel, S. , TURNER, Sean, C. , KRUGER, Albert, W. , RELO, Ana-Lucia , SHEKHAR, Shashank , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan, F. , LI, Huanqiu , THOMPSON, Christina, M. , ZHANG, Min
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , A61P25/00 , A61K31/551 , A61K31/554 , A61K31/553
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
摘要： The present application relates to processes for making aryl- and heteroaryl-fused decahydropyrroloazepine derivatives of formula (1-5), wherein the variables are as defined in the specification.
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公开(公告)号：EP2167491A1
公开(公告)日：2010-03-31
申请号：EP08770094.4
申请日：2008-06-04
发明人： AKRITOPOULOU-ZANZE, Irini , WAKEFIELD, Brian D , MACK, Helmut , TURNER, Sean C , GASIECKI, Alan F , GRACIAS, Vijaya J , SARRIS, Kathy , KALVIN, Douglas M , MICHMERHUIZEN, Melissa J , SHUAI, Qi , PATEL, Jyoti R , BAKKER, Margaretha , TEUSCH, Nicole , JOHNSON, Eric F. , KOVAR, Peter J , DJURIC, Stevan W , LONG, Andrew J , VASUDEVAN, Anil , HOBSON, Adrian , ST. JOHN MOORE, Nigel , WANG, Lu , GEORGE, Dawn , LI, Biqin , FRANK, Kristine
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.
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公开(公告)号：EP2432783B1
公开(公告)日：2013-05-01
申请号：EP10720502.3
申请日：2010-05-20
发明人： WELCH, Dennie, S. , AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan, W. , WILSON, Noel, S. , TURNER, Sean, C. , KRUGER, Albert, W. , RELO, Ana-Lucia , SHEKHAR, Shashank , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan, F. , LI, Huanqiu , THOMPSON, Christina, M. , ZHANG, Min
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , A61P25/00 , A61K31/551 , A61K31/554 , A61K31/553
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
摘要： The present application relates to processes for making aryl- and heteroaryl-fused decahydropyrroloazepine derivatives of formula (1-5), wherein the variables are as defined in the specification.
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