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公开(公告)号：EP3891187A1
公开(公告)日：2021-10-13
申请号：EP19890398.1
申请日：2019-02-15
发明人： PARK, Eunyoung , LEE, Yangsoon , CHUNG, Hyejin , SUNG, Eunsil , YOO, Jiseon , PARK, Minji , SON, Yong-Gyu , CHOI, Hyoju , KIM, Eunjung , JUNG, Jaeho , YOU, Weon-Kyoo , LEE, Sang Hoon , FANG, Lei , JIANG, Wenqing
IPC分类号： C07K16/46 , C12N15/13 , A61K39/395 , A61P35/00
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公开(公告)号：EP4403218A2
公开(公告)日：2024-07-24
申请号：EP24170761.1
申请日：2018-12-14
申请人： ABL Bio, Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-Gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
IPC分类号： A61P25/00
CPC分类号： C07K16/2863 , C07K16/18 , C07K2317/3120130101 , C07K2317/9420130101 , C07K2317/9220130101 , C07K2317/7720130101 , A61P25/16 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3420130101 , C07K2317/3520130101 , C07K2317/52620130101 , C07K2317/56520130101 , C07K2317/62220130101 , C07K2317/3320130101 , A61K2039/50520130101 , A61P25/00
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：EP4025257A1
公开(公告)日：2022-07-13
申请号：EP20861806.6
申请日：2020-07-27
发明人： PARK, Yun Hee , SONG, Ho Young , RYU, Hyun Min , KIM, Sung Min , BAEK, Ju Yuel , OH, Ji Hye , HAN, Nara , KIM, Hyoung Rae , PARK, Kyung Eun , LEE, Hyeun Joung , LEE, Ju Young , KANG, Dae Hyuck , YANG, Young-Jae , YOU, Ji-Na , KIM, Yong Zu , LEE, Chang Sun , CHAE, Jeiwook , JUNG, Jinwon , KIM. Juhee , LEE, Bora , SONG, Daehae , SUNG, Byungje , YEOM, Donghoon , EOM, Jaehyun , HONG, Youngeun , AHN, Jinhyung , LEE, Yangsoon , PARK, Kyungjin , YOO, Jiseon , PARK, Minji
IPC分类号： A61K47/68 , A61K31/5517 , A61P35/00 , C07K16/28
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公开(公告)号：EP4403218A3
公开(公告)日：2024-11-06
申请号：EP24170761.1
申请日：2018-12-14
申请人： ABL Bio, Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-Gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：EP3777895A1
公开(公告)日：2021-02-17
申请号：EP19826406.1
申请日：2019-06-26
申请人： ABL Bio Inc.
发明人： PARK, Kyungjin , CHUNG, Hyejin , PARK, Kyeongsu , LEE, Yangsoon , CHANG, Mikyung , JEON, Jaehyoung , KIM, Youngkwang , JEONG, Junhyun , YOO, Jiseon , KIM, Yeunju , YEOM, Donghoon , KIM, Eunjung , LEE, Bora , JUNG, Jinwon
摘要： Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.
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公开(公告)号：EP3725806A1
公开(公告)日：2020-10-21
申请号：EP18889608.8
申请日：2018-12-14
申请人： ABL Bio Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.
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