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    METHOD AND SYSTEM FOR IN VITRO DEVELOPMENTAL TOXICITY TESTING
    3.
    发明公开
    METHOD AND SYSTEM FOR IN VITRO DEVELOPMENTAL TOXICITY TESTING 有权
    VERFAHREN UND SYSTEMFÜRIN-VITRO-ENTWICKLUNGSTOXIZITÄTSPRÜFUNG

    公开(公告)号：EP2900807A4

    公开(公告)日：2016-06-01

    申请号：EP13840538

    申请日：2013-09-30

    申请人： AGENCY SCIENCE TECH & RES

    发明人： YU HANRY ,  TOH YI-CHIN ,  XING JIANGWA

    IPC分类号： C12N5/0735 ,  G01N33/48 ,  G01N33/50

    CPC分类号： G01N33/5014 ,  G01N33/5026 ,  G01N33/5044 ,  G01N33/5073

    摘要： A method and system of in vitro developmental toxicity testing comprising the steps of micropatterning an extracellular matrix; growing embryonic stem cells on the micropatterned extracellular matrix in the presence of mesoendermal induction and testing for change of the geometrical mesoendoderm structure in the presence or absence of a test compound wherein (1) a decrease in mesoendodermal differentiation and/or (2) a change in morphology of the geometrical mesoendoderm structure in the presence of the test compound compared to cells in the absence of the test compound indicates that the test compound is a developmental toxic agent.

    摘要翻译： 一种体外发育毒性试验的方法和系统，包括微细胞外基质的步骤; 在存在或不存在测试化合物的情况下，在介孔介导诱导的存在下在微图案化的细胞外基质上培养胚胎干细胞并测试几何中胚层结构的变化，其中（1）中胚层分化的减少和/或（2）变化 在不存在测试化合物的情况下，在测试化合物存在下的几何中内胚层结构的形态学表明测试化合物是发育毒性剂。

    APPARATUS FOR CULTURING ANCHORAGE DEPENDENT CELLS
    4.
    发明公开
    APPARATUS FOR CULTURING ANCHORAGE DEPENDENT CELLS 有权
    VORRICHTUNG ZUR KULTIVIERUNGVERANKERUNGSABHÄNGIGERZELLEN

    公开(公告)号：EP2344622A4

    公开(公告)日：2014-04-23

    申请号：EP09819524

    申请日：2009-10-08

    申请人： AGENCY SCIENCE TECH & RES

    发明人： YU HANRY ,  XIA LEI ,  LEO HWA LIANG

    IPC分类号： C12M1/14 ,  C12M1/00 ,  C12M3/00 ,  C12M3/06 ,  C12N5/071

    CPC分类号： C12M23/44 ,  C12M21/08 ,  C12M23/34 ,  C12M23/46 ,  C12M23/58 ,  C12M25/06 ,  C12M29/10

    摘要： The invention relates to an apparatus (1) for culturing anchorage-dependent cells. The apparatus (1) comprises a housing (2) with an inlet (4) and an outlet (5), and a plurality of culture plates (6) removably stacked within the housing (2). The housing (2) has a circumferential wall (7), a base (8) and a top wall (9). The base (8) comprises the inlet (4) and the top wall (9) comprises the outlet (5). The circumferential wall (7) of the housing (2) defines a longitudinal axis thereof, as well as an inner cross section perpendicular to the longitudinal axis. Shape and dimensions of the inner cross section are essentially uniform along the longitudinal axis. The culture plates (6) are arranged at least essentially parallel to each other. Each plate (6) is mounted and sealed to the circumferential wall (7) of the housing (2). Plates (6) are arranged at a distance from each other. Each culture plate (6) has a through hole (14), so that inlet (4) and outlet (5) are in fluid communication. Each through hole (14) is positioned at an outer end of the respective culture plate (6), proximate the circumferential wall (7). Through holes (14) of adjacent culture plates (6) are distally positioned in the plane of the inner cross section of the housing (2).

    摘要翻译： 本发明涉及一种用于培养锚固依赖细胞的装置（1）。 装置（1）包括具有入口（4）和出口（5）的壳体（2）和可移除地堆叠在壳体（2）内的多个培养板（6）。 壳体（2）具有圆周壁（7），基部（8）和顶壁（9）。 底座（8）包括入口（4），顶壁（9）包括出口（5）。 壳体（2）的周向壁（7）限定其纵向轴线，以及垂直于纵向轴线的内部横截面。 内横截面的形状和尺寸沿着纵向轴线基本均匀。 培养板（6）至少基本上彼此平行地布置。 每个板（6）被安装并密封到壳体（2）的周壁（7）。 板（6）彼此间隔一定距离。 每个培养板（6）具有通孔（14），使得入口（4）和出口（5）流体连通。 每个通孔（14）位于相应的培养板（6）的外端处，靠近周壁（7）。 相邻培养皿（6）的通孔（14）远离定位在壳体（2）的内横截面的平面内。

    SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE
    9.
    发明公开
    SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE 审中-公开
    新疆维吾尔自治区ON IX UNG UNG UNG UNG UNG UNG UNG UNG

    公开(公告)号：EP2033047A4

    公开(公告)日：2010-06-30

    申请号：EP07748739

    申请日：2007-06-29

    申请人： AGENCY SCIENCE TECH & RES

    发明人： SUN WANXIN ,  YU HANRY

    IPC分类号： G02F1/37 ,  G01N21/64 ,  G02B21/00 ,  G02B21/08

    CPC分类号： G02B21/0024 ,  G01N21/6458 ,  G01N21/6486 ,  G02B21/086

    摘要： A microscope for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source for irradiating a scan area of the sample and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element for scanning the light over the sample; a focusing element having a numerical aperture NAi to focus the light onto the sample; a first optical condenser to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector collecting light from the first face for detecting the first optical emission from the scan area.

    摘要翻译： 一种用于高光学散射系数生物组织的光学成像的显微镜，包括用于照射样品的扫描区域并产生光学发射的光学激发源，其中样品具有面向源的第一面和面向源的第二面 。 用于扫描样品上的光的二维元素; 具有数值孔径NAi以将光聚焦到样本上的聚焦元件; 收集来自所述第一面的光的第一光学聚光器，所述收集的光包括源透射光和在所述样品中产生的第一光发射，所述冷凝器的NA2大于NAi; 滤光器，用于阻挡发射光源; 具有对应于样品的照射面积的尺寸的孔，由冷凝器产生的样品的共轭图像位置处的孔; 以及光学检测器，其从第一面收集光，以检测来自扫描区域的第一光发射。