Method for simulating a production process of a substance
    4.
    发明公开
    Method for simulating a production process of a substance 审中-公开
    Verfahren zur Simulation eines Herstellungsprozesses eines Stoffes

    公开(公告)号:EP1752899A1

    公开(公告)日:2007-02-14

    申请号:EP06016619.6

    申请日:2006-08-09

    IPC分类号: G06F19/00

    CPC分类号: G06F19/12

    摘要: A method for simulating a substance production process using cells based on differential equations concerning intracellular metabolites and gene expression comprising preparing the differential equations concerning intracellular metabolites and gene expression, assigning values for parameters in the differential equations required for the simulation and solving the differential equations with the assigned values, which is characterized by the following (a) to (d): (a) the differential equations include a differential equation including a specific growth rate of the cells, and the specific growth rate is represented as a function of time; (b) all or a part of parameters of the differential equations are represented as a function of the specific growth rate or a function of time; (c) the differential equations include a formation rate for formation of a cell component from an intracellular metabolite, and the formation rate is represented as a function of the specific growth rate or a function of time; and (d) the differential equations include an inflow rate of a metabolite taken up from the outside of the cells and/or an outflow rate of a metabolite excreted out of the cells from the inside of the cells, and the inflow rate and/or the outflow rate is represented as a function of the specific growth rate or a function of time.

    摘要翻译: 一种使用基于细胞内代谢物和基因表达的微分方程的细胞模拟物质生产过程的方法,包括制备关于细胞内代谢物和基因表达的微分方程,为模拟所需的微分方程分配参数值并求解微分方程, 分配值,其特征在于以下(a)至(d):(a)微分方程包括包括细胞的比生长速率的微分方程,并且比生长速率表示为时间的函数; (b)将微分方程的全部或部分参数表示为比生长速率或时间函数的函数; (c)微分方程包括从细胞内代谢物形成细胞成分的形成速率,并且形成速率表示为比生长速率或时间函数的函数; 和(d)微分方程式包括从细胞外吸收的代谢物的流入速率和/或从细胞内部排出细胞的代谢物的流出速率和流入速率和/或 流出率表示为比生长速率或时间函数的函数。