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    METHOD OF DECOMPOSING PROTEIN WITH SULFONIC ACID COMPOUND
    2.
    发明公开
    METHOD OF DECOMPOSING PROTEIN WITH SULFONIC ACID COMPOUND 审中-公开
    METHOD FOR蛋白与磺酸REMOVAL

    公开(公告)号：EP1522593A4

    公开(公告)日：2008-07-23

    申请号：EP03720985

    申请日：2003-04-28

    申请人： ARKRAY INC

    发明人： YONEHARA SATOSHI ,  ISHIMARU KAORI ,  HIRAI KAORU

    IPC分类号： C12Q1/26 ,  C12Q1/37 ,  G01N33/72 ,  G01N33/14 ,  G01N33/50

    CPC分类号： G01N33/723 ,  C12Q1/26 ,  C12Q1/37 ,  G01N2333/906

    摘要： A method of assaying a saccharified protein in a sample with the use of oxidation-reduction reaction, in which highly reliable measurements can be obtained. A sample containing a saccharified protein is treated with protease in the presence of a sulfonic acid compound, so that the saccharified protein is decomposed. Saccharified portion of the resultant saccharified protein decomposition product is reacted with fructosylamino acid oxidase, and this oxidation-reduction reaction is measured, thereby determining the amount of saccharified protein. Sodium laurylsulfate can be used as the sulfonic acid compound.

    SPECIMEN HAVING CAPABILITY OF SEPARATING SOLID COMPONENT
    4.
    发明公开
    SPECIMEN HAVING CAPABILITY OF SEPARATING SOLID COMPONENT 有权
    模式，容量已经分离固体组分

    公开(公告)号：EP1271143A4

    公开(公告)日：2007-04-18

    申请号：EP01912407

    申请日：2001-03-15

    申请人： ARKRAY INC

    发明人： HIRAI KAORU ,  YONEHARA SATOSHI

    IPC分类号： G01N21/78 ,  G01N31/22 ,  G01N21/68 ,  G01N21/86 ,  G01N33/48 ,  G01N33/50 ,  G01N33/52

    CPC分类号： G01N21/78 ,  G01N21/8483 ,  G01N33/5002 ,  G01N33/521 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A specimen having the capability of separating a solid component, characterized in that it comprises a porous reagent layer containing beads, an inorganic gel and a reagent undergoing a detectable reaction with a substance to be detected and a support for the reagent layer, wherein the beads are adhered to one another by the inorganic gel, interstices are formed between the beads to capture the solid component. The specimen can thus used for separating a blood cell component from a total blood containing a blood cell component and a blood plasma component and detecting a substance to be detected, such as glucose, contained in the plasma component. The use of the specimen allows the measurement of a substance to be detected by means of a transmitted light, exhibits good oxygen permeability, and thus can be used for measuring a substance to be detected with improved accuracy.

    METHOD OF ASSAY WITH SULFONIC ACID COMPOUND AND NITRO COMPOUND
    5.
    发明公开
    METHOD OF ASSAY WITH SULFONIC ACID COMPOUND AND NITRO COMPOUND 有权
    与磺酸和硝基化合物测试程序

    公开(公告)号：EP1515144A4

    公开(公告)日：2006-05-17

    申请号：EP03720984

    申请日：2003-04-28

    申请人： ARKRAY INC

    发明人： YONEHARA SATOSHI ,  ISHIMARU KAORI ,  HIRAI KAORU

    IPC分类号： C12Q1/26 ,  C12Q1/28 ,  G01N33/72 ,  G01N21/77 ,  G01N31/00 ,  G01N33/66

    CPC分类号： C12Q1/28 ,  C12Q1/26 ,  G01N33/72

    摘要： A method for determining a substance in a sample through an oxidation-reduction reaction, which gives found values with excellent reliability. Prior to the oxidation-reduction reaction, at least either of a sulfonic acid compound and a nitro compound is added to the sample to eliminate the influence of hemoglobin and any hemoglobin decomposition products as reducible substances contained in the sample. Subsequently, a reduction or oxidation product derived from the substance to be assayed is caused to generate, and the amount thereof is measured by an oxidation-reduction reaction. The amount of the substance to be assayed is determined from the found value. The sulfonic acid compound may be sodium lauryl sulfate, and the nitro compound may be 4-nitrophenol, etc.

    METHOD OF PRE-TREATING SAMPLE FOR MEASURING SACCHARIFIED AMINE AND METHOD OF MEASURING SACCHARIFIED AMINE
    6.
    发明公开
    METHOD OF PRE-TREATING SAMPLE FOR MEASURING SACCHARIFIED AMINE AND METHOD OF MEASURING SACCHARIFIED AMINE 有权
    工艺用于样品的用于确定加糖AMINES用于确定加糖胺准备和方法

    公开(公告)号：EP1443115A4

    公开(公告)日：2006-02-01

    申请号：EP02801510

    申请日：2002-10-09

    申请人： ARKRAY INC

    发明人： YONEHARA SATOSHI ,  KOMORI TSUGUKI

    IPC分类号： C12Q1/26 ,  C12Q1/37 ,  G01N33/68 ,  G01N33/72 ,  C12Q1/28 ,  G01N33/48 ,  G01N33/50

    CPC分类号： C12Q1/26 ,  C12Q1/37 ,  G01N33/723 ,  G01N2333/906

    摘要： It is intended to provide a method of pre-treating a sample for measuring a saccharified amine to thereby enable highly reliable measurement of the saccharified amine. A saccharified amino acid in the sample is decomposed by treating with fructosyl amino acid oxidase FAOD, then the saccharified amine to be measured contained in the sample is treated with FAOD and the oxidation-reduction reaction is measured to thereby quantify the saccharified amine. The FAOD whereby the saccharified amino acid is treated and the FAOD whereby the saccharified amine is treated may have either the same or different substrate specificities. In case of using the same FAOD, the saccharified amino acid is decomposed by treating with the FAOD and then the FAOD is inactivated with a protease. At the same time, the saccharified amine is decomposed and the same FAOD is added to the decomposition product followed by the measurement of the oxidation-reduction reaction.

    METHOD OF QUANTIFYING HEMOGLOBIN AND METHOD OF MEASURING GLYCATION RATIO OF HEMOGLOBIN
    9.
    发明公开
    METHOD OF QUANTIFYING HEMOGLOBIN AND METHOD OF MEASURING GLYCATION RATIO OF HEMOGLOBIN 有权
    方法定量血红蛋白和方法用于测量GLYKATIONSVERHÄLTNISSES血红蛋白

    公开(公告)号：EP1329721A4

    公开(公告)日：2006-08-23

    申请号：EP01970262

    申请日：2001-09-27

    申请人： ARKRAY INC

    发明人： YONEHARA SATOSHI ,  YAGI YUJI

    IPC分类号： G01N21/31 ,  G01N21/78 ,  G01N33/72

    CPC分类号： G01N33/721 ,  G01N21/31 ,  G01N21/78 ,  G01N33/723 ,  Y10S436/904

    摘要： A method of quantifying hemoglobin whereby the Hb content in a sample can be easily and accurately determined without causing any environmental problem. Hemoglobin in a sample is denatured with a tetrazolium compound and then the optical change of the sample is measured at an absorption wavelength specific to the denatured hemoglobin thus obtained. The hemoglobin content in the sample can be calculated based on the optical change. The measurement wavelength as described above preferably falls within a range of from 520 to 670 nm. According to this method, the Hb content can be determined at a high accuracy, as shown in fig. 1.

    METHOD OF PREVENTING WRONG COLOR FORMATION OF N-(CARBOXYMETHYLAMINOCARBONYL)-4,4 -BIS(DIMETHYLAMINO)DIPHENYLAMINE SODIUM, REA GENT SOLUTION FOR THE METHOD, AND MEASUREMENT METHOD EMPLOYING THE METHOD
    10.
    发明公开
    METHOD OF PREVENTING WRONG COLOR FORMATION OF N-(CARBOXYMETHYLAMINOCARBONYL)-4,4 -BIS(DIMETHYLAMINO)DIPHENYLAMINE SODIUM, REA GENT SOLUTION FOR THE METHOD, AND MEASUREMENT METHOD EMPLOYING THE METHOD 有权
    方法，用于防止错误的COLOR N-（羧甲基氨基羰基）-4,4-双（二甲氨基）联苯胺钠，试剂溶液中形成FOR THE METHOD AND过程中使用的测量方法

    公开(公告)号：EP1512751A4

    公开(公告)日：2006-05-03

    申请号：EP03725755

    申请日：2003-05-02

    申请人： ARKRAY INC

    发明人： YONEHARA SATOSHI ,  KOMORI TSUGUKI

    IPC分类号： C12Q1/26

    CPC分类号： C12Q1/26

    摘要： A method of preventing wrong color formation of N-(carboxymethylaminocarbonyl)-4,4'-bis(dimethylamino)diphenylamine sodium as a color-forming substrate to thereby improve the precision of determination based on an oxidation-reduction reaction with the color-forming substrate. A tetrazolium compound, a sodium azide, and the color-forming substrate are added to a sample in the presence of a surfactant, and that oxidizing substance in the sample which is derived from a substance to be determined is reacted, with the aid of an oxidoreductase, with the color-forming substrate which forms a color upon oxidation. The amount of the oxidizing substance is determined by measuring the amount of the color formed. In the reaction mixture, the amounts of the tetrazolium compound, sodium azide, and surfactant are in the ranges of 0.01 to 1 mmol, 0.003 to 0.5 mmol, and 0.006 to 0.4 mmol, respectively, per µmol of the color-forming substrate. The pH of the reaction mixture is adjusted to 6 to 9.