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公开(公告)号：EP1728784A4
公开(公告)日：2008-02-20
申请号：EP05710602
申请日：2005-02-17
申请人： ASTELLAS PHARMA INC
发明人： YAMADA HIROYOSHI , ITAHANA HIROTSUNE , MORITOMO AYAKO , MATSUZAWA TAKAHO , HARADA KOICHIRO , FUJIYASU JIRO , KOGA YUJI , OKU MAKOTO , OKAZAKI TOSHIO , AKUZAWA SHINOBU , WATANABE TOSHIHIRO
IPC分类号： C07C279/22 , A61K31/166 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/385 , A61K31/41 , A61K31/4168 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/438 , C07D207/20 , C07D209/54 , C07D209/96 , C07D211/70 , C07D221/20 , C07D233/50 , C07D249/14 , C07D257/06 , C07D263/28 , C07D277/18 , C07D303/06 , C07D305/14 , C07D307/94 , C07D309/06 , C07D309/20 , C07D311/96 , C07D317/12 , C07D319/14 , C07D327/04 , C07D335/04 , C07D339/06
CPC分类号： C07D311/96 , A61K31/166 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/385 , A61K31/41 , A61K31/4168 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/438 , C07C279/22 , C07D207/20 , C07D209/54 , C07D209/96 , C07D211/70 , C07D221/20 , C07D233/50 , C07D249/14 , C07D257/06 , C07D263/28 , C07D277/18 , C07D303/06 , C07D305/14 , C07D307/94 , C07D309/06 , C07D309/20 , C07D317/12 , C07D319/14 , C07D327/04 , C07D335/04 , C07D339/06
摘要： A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly for 5-HT2B receptor and 5-HT7 receptor, among serotonin receptor subtypes, and exhibiting an excellent pharmacological effect compared with a conventional compound having an antagonistic activity to only one of the 5-HT2B receptor and 5-HT7 receptor. Thus, it is useful as a highly efficacious and safe preventive for migraine.
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公开(公告)号：EP1923387A4
公开(公告)日：2009-10-28
申请号：EP06782418
申请日：2006-08-07
申请人： ASTELLAS PHARMA INC
发明人： YAMADA HIROYOSHI , ITAHANA HIROTSUNE , MORITOMO AYAKO , MATSUZAWA TAKAHO , NOZAWA EISUKE , AKUZAWA SHINOBU , HARADA KOICHIRO
IPC分类号： C07D209/88 , A61K31/381 , A61K31/385 , A61K31/403 , A61K31/407 , A61K31/435 , A61K31/437 , A61K31/438 , A61K31/454 , A61K31/5377 , A61K31/538 , A61P1/00 , A61P25/06 , A61P43/00 , C07D221/16 , C07D265/38 , C07D333/78 , C07D401/04 , C07D403/04 , C07D405/04
CPC分类号： C07D209/88 , C07D221/16 , C07D265/38 , C07D333/78 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/06 , C07D413/04 , C07D413/06 , C07D471/04 , C07D491/10 , C07D495/10
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公开(公告)号：EP2772484A4
公开(公告)日：2015-03-25
申请号：EP12840990
申请日：2012-10-17
申请人： ASTELLAS PHARMA INC
发明人： KAWAKAMI SHIMPEI , SAKURAI MINORU , KAWANO NORIYUKI , SUZUKI TAKAYUKI , SHIRAISHI NOBUYUKI , HAMAGUCHI WATARU , SEKIOKA RYUICHI , MORITOMO HIROYUKI , MORITOMO AYAKO
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P3/10 , A61P19/10 , A61P25/04 , A61P25/18
CPC分类号： C07D237/28 , C07D231/56 , C07D239/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04
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公开(公告)号：EP2301922A4
公开(公告)日：2012-06-06
申请号：EP09766638
申请日：2009-06-16
申请人： ASTELLAS PHARMA INC
发明人： KAMIKUBO TAKASHI , MIURA MASANORI , OKUDA TAKAO , MAKI KEISUKE , HIRAYAMA FUKUSHI , MORITOMO AYAKO , KOMIYA YURIKO , MATSUURA KEISUKE , IBUKA RYOTARO
IPC分类号： C07D213/64 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/538 , A61K31/5415 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07D213/69 , C07D213/79 , C07D401/06 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/12
CPC分类号： C07D401/06 , A61K31/13 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/538 , A61K31/5415 , C07D213/64 , C07D213/69 , C07D213/79 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/12
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