公开(公告)号：EP1553094A4

公开(公告)日：2006-10-11

申请号：EP03766722

申请日：2003-08-04

申请人： ASTELLAS PHARMA INC ,  KOTOBUKI PHARMACEUTICAL CO LTD

发明人： TOMIYAMA HIROSHI ,  NODA ATSUSHI ,  KITTA KAYOKO ,  KOBAYASHI YOSHINORI ,  IMAMURA MASAKAZU ,  MURAKAMI TAKESHI ,  IKEGAI KAZUHIRO ,  SUZUKI TAKAYUKI ,  KUROSAKI EIJI

IPC分类号： C07D309/12 ,  A61K31/351 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07D309/10

CPC分类号： C07D309/12 ,  C07D309/10

摘要： Azulene derivatives represented by the following general formula (I) and salts thereof are useful as Na+-glucose cotransporter inhibitors in, for example, remedies for diabetes, etc., in particular, insulin-independent diabetes (type 2 diabetes), insulin-dependent diabetes (type 1 diabetes), etc., and remedies for various diabetes-related diseases such as insulin resistant disease and obesity. These compounds are characterized in that an azulene ring is bonded, either directly or via an optionally halogenated lower alkylene, to a benzene ring and the benzene ring is directly bonded to a sugar residue.

公开(公告)号：EP1609785A4

公开(公告)日：2008-10-22

申请号：EP04720254

申请日：2004-03-12

申请人： ASTELLAS PHARMA INC ,  KOTOBUKI PHARMACEUTICAL CO LTD

发明人： IMAMURA MASAKAZU ,  MURAKAMI TAKESHI ,  SHIRAKI RYOTA ,  IKEGAI KAZUHIRO ,  SUGANE TAKASHI ,  IWASAKI FUMIYOSHI ,  KUROSAKI EIJI ,  TOMIYAMA HIROSHI ,  NODA ATSUSHI ,  KITTA KAYOKO ,  KOBAYASHI YOSHINORI

IPC分类号： A61K31/351 ,  A61K31/381 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  C07D207/06 ,  C07D309/10 ,  C07D333/12 ,  C07D333/16 ,  C07D333/54 ,  C07D405/04 ,  C07D405/10 ,  C07D407/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D417/10 ,  C07D493/04 ,  C07D495/04 ,  A61K31/49 ,  C07D407/10

CPC分类号： C07D495/04 ,  A61K31/351 ,  A61K31/381 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/5377 ,  C07D405/10 ,  C07D407/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

摘要： A C-glycoside derivative represented by the following general formula (I) or its salt which is a compound useful as a Na+-glucose co-transportation inhibitor in a remedy for, e.g., diabetes, in particular, insulin-independent diabetes (type 2 diabetes) and insulin-dependent diabetes (type 1 diabetes), as well as a remedy for insulin resistance diseases and various diseases relating to diabetes including obesity. This compound is characterized in that the ring B is bonded to the ring A via -X- and the ring A is bonded directly to a sugar residue.