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1.发明公开PROCESS FOR PRODUCTION OF AZULENE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS OF THE SAME 审中-公开用于生产甘菊环烃衍生物和中间产品及其合成
公开(公告)号：EP1783122A4
公开(公告)日：2008-12-10
申请号：EP05765585
申请日：2005-07-07
发明人： TOMIYAMA HIROSHI , YOKOTA MASAYUKI , NODA ATSUSHI , KOBAYASHI Y , OGASAWARA JUNKO , HAYASHI YASUMASA , INAKOSHI MASATOSHI , NAKAMURA HIROFUMI , KOIDE TOKUO , SAKAMOTO KENICHIRO , YAMASHITA YOHEI , MIYAFUJI AKIO , SUZUKI TAKAYUKI , KAWANO NORIYUKI , MIYATA JUNJI , IMAMURA MASAKAZU , SUGANE TAKASHI
IPC分类号： C07D309/10 , C07C43/225 , C07C49/223 , C07H7/04 , C07H15/04
CPC分类号： C07C49/255 , C07C45/48 , C07C45/63 , C07C45/71 , C07C49/245 , C07H7/04 , C07H15/04
摘要： A process for producing azulene derivatives useful as Na+-glucose cotransporter inhibitor easily and simply in high yield at a low cost which is industrially advantageous and excellent in environmental protection, characterized by subjecting at least one compound selected from among specific penta- and tetraacyl precursors of the azulene derivatives and salts of the precursors to reduction and deblocking to obtain a C-glycoside compound; and useful intermediates obtained in the above process.
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公开(公告)号：EP1609785A4
公开(公告)日：2008-10-22
申请号：EP04720254
申请日：2004-03-12
发明人： IMAMURA MASAKAZU , MURAKAMI TAKESHI , SHIRAKI RYOTA , IKEGAI KAZUHIRO , SUGANE TAKASHI , IWASAKI FUMIYOSHI , KUROSAKI EIJI , TOMIYAMA HIROSHI , NODA ATSUSHI , KITTA KAYOKO , KOBAYASHI YOSHINORI
IPC分类号： A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , A61P3/04 , A61P3/10 , C07D207/06 , C07D309/10 , C07D333/12 , C07D333/16 , C07D333/54 , C07D405/04 , C07D405/10 , C07D407/04 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D493/04 , C07D495/04 , A61K31/49 , C07D407/10
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： A C-glycoside derivative represented by the following general formula (I) or its salt which is a compound useful as a Na+-glucose co-transportation inhibitor in a remedy for, e.g., diabetes, in particular, insulin-independent diabetes (type 2 diabetes) and insulin-dependent diabetes (type 1 diabetes), as well as a remedy for insulin resistance diseases and various diseases relating to diabetes including obesity. This compound is characterized in that the ring B is bonded to the ring A via -X- and the ring A is bonded directly to a sugar residue.
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公开(公告)号：EP2042498A4
公开(公告)日：2011-11-09
申请号：EP07790741
申请日：2007-07-13
申请人： ASTELLAS PHARMA INC
发明人： HAMADA NORITAKA , MIZOGUCHI RYO , SANO KUNIYUKI , SAKAIDA TAKAAKI , AWAMURA YUJI , IWAKAWA YU , TOBE TAKAHIKO , SUGANE TAKASHI
IPC分类号： C07D413/14 , A61K31/4439 , A61P25/18 , A61P25/28 , A61P43/00
CPC分类号： C07D413/14
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公开(公告)号：EP1293503A4
公开(公告)日：2008-04-02
申请号：EP01930192
申请日：2001-05-17
申请人： ASTELLAS PHARMA INC
发明人： TOBE TAKAHIKO , SUGANE TAKASHI , HAMAGUCHI WATARU , SHIMADA ITSURO , MAENO KYOICHI , MIYATA JUNJI , KIMIZUKA TETSUYA , SUZUKI TAKESHI , KOHARA ATSUYUKI , MORITA TAKUMA , ARLT MICHAEL , GREINER HARTMUT
IPC分类号： A61K31/41 , A61K31/4155 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61P9/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/10 , C07D495/04
CPC分类号： C07D249/08 , A61K31/41 , A61K31/4155 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , C07D249/10 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/10 , C07D495/04
摘要： Triazole derivatives which have a glycine transporter inhibitory activity and are useful as drugs; and novel triazole derivatives. Because of having an excellent glycine transporter inhibitory activity, the above triazole derivatives are useful as remedies.
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公开(公告)号：EP2065369A4
公开(公告)日：2011-12-28
申请号：EP07792835
申请日：2007-08-22
申请人： ASTELLAS PHARMA INC
发明人： ISHII TAKAHIRO , SUGANE TAKASHI , KAKEFUDA AKIO , TAKAHASHI TATSUHISA , KANAYAMA TAKATOSHI , SATO KENTARO , KURIWAKI IKUMI , KITADA CHIKA , SUZUKI JOTARO
IPC分类号： C07D209/08 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/53 , A61K31/5377 , A61P13/02 , A61P13/10 , C07D211/44 , C07D213/74 , C07D235/30 , C07D237/22 , C07D249/14 , C07D251/42 , C07D285/135 , C07D295/16 , C07D401/12 , C07D405/12
CPC分类号： C07D209/08 , C07D211/44 , C07D213/74 , C07D235/30 , C07D237/22 , C07D249/14 , C07D251/42 , C07D285/135 , C07D295/16 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
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公开(公告)号：EP2308869A4
公开(公告)日：2011-07-27
申请号：EP09797891
申请日：2009-07-13
申请人： ASTELLAS PHARMA INC
发明人： AOKI SATOSHI , MUNAKATA RYOSUKE , KAWANO NORIYUKI , SAMIZU KIYOHIRO , OKA HIROMASA , ISHII TAKAHIRO , SUGANE TAKASHI
IPC分类号： C07D401/14 , A61K31/4545 , A61P25/04 , A61P43/00 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2631233A4
公开(公告)日：2014-03-19
申请号：EP11834469
申请日：2011-10-21
申请人： ASTELLAS PHARMA INC
发明人： IDEYAMA YUKITAKA , KUROMITSU SADAO , FURUTANI TAKASHI , TAKEDA MASAYOSHI , KONAGAI SATOSHI , YAMADA TOMOHIRO , TANIGUCHI NOBUAKI , KONDOH YUTAKA , HIRANO MASAAKI , WATANABE KAZUSHI , SUGANE TAKASHI , KAKEFUDA AKIO
IPC分类号： C07D401/12 , A61K31/496 , A61K31/506 , A61P5/26 , A61P35/00 , C07D403/12
CPC分类号： C07D401/02 , A61K31/496 , A61K31/506 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/12
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8.发明公开PYRIDYL NON-AROMATIC NITROGENATED HETEROCYCLIC-1-CARBOXYLATE ESTER DERIVATIVE 有权吡啶基（不是芳族氮化杂环-1-羧酸酯）衍生物
公开(公告)号：EP1849773A4
公开(公告)日：2011-06-15
申请号：EP06713839
申请日：2006-02-16
申请人： ASTELLAS PHARMA INC
发明人： ISHII TAKAHIRO , SUGANE TAKASHI , MAEDA JUN , NARAZAKI FUMIE , KAKEFUDA AKIO , SATO KENTARO , TAKAHASHI TATSUHISA , KANAYAMA TAKATOSHI , SAITOH CHIKASHI , SUZUKI JOTARO , KANAI CHISATO
IPC分类号： C07D213/65 , A61K31/44 , A61K31/4545 , A61K31/4709 , C07D213/80 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
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