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公开(公告)号：EP1553094A4
公开(公告)日：2006-10-11
申请号：EP03766722
申请日：2003-08-04
发明人： TOMIYAMA HIROSHI , NODA ATSUSHI , KITTA KAYOKO , KOBAYASHI YOSHINORI , IMAMURA MASAKAZU , MURAKAMI TAKESHI , IKEGAI KAZUHIRO , SUZUKI TAKAYUKI , KUROSAKI EIJI
IPC分类号： C07D309/12 , A61K31/351 , A61P3/04 , A61P3/10 , A61P43/00 , C07D309/10
CPC分类号： C07D309/12 , C07D309/10
摘要： Azulene derivatives represented by the following general formula (I) and salts thereof are useful as Na+-glucose cotransporter inhibitors in, for example, remedies for diabetes, etc., in particular, insulin-independent diabetes (type 2 diabetes), insulin-dependent diabetes (type 1 diabetes), etc., and remedies for various diabetes-related diseases such as insulin resistant disease and obesity. These compounds are characterized in that an azulene ring is bonded, either directly or via an optionally halogenated lower alkylene, to a benzene ring and the benzene ring is directly bonded to a sugar residue.
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公开(公告)号：EP1908757A4
公开(公告)日：2010-05-19
申请号：EP06767927
申请日：2006-07-06
发明人： IMAMURA MASAKAZU , SUZUKI TAKAYUKI , MURAKAMI TAKESHI , NAKANISHI KEITA , UEBAYASHI HIROSHI , NAKAMURA HARUKA , YUDA MASAMICHI , AMENOMIYA NAOKO , AWAMURA YUUJI , TOMIYAMA HIROSHI
IPC分类号： C07D309/10 , A61K31/351 , A61P3/10 , C07C215/90
CPC分类号： C07C215/90 , C07D309/10
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3.发明公开PROCESS FOR PRODUCTION OF AZULENE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS OF THE SAME 审中-公开用于生产甘菊环烃衍生物和中间产品及其合成
公开(公告)号：EP1783122A4
公开(公告)日：2008-12-10
申请号：EP05765585
申请日：2005-07-07
发明人： TOMIYAMA HIROSHI , YOKOTA MASAYUKI , NODA ATSUSHI , KOBAYASHI Y , OGASAWARA JUNKO , HAYASHI YASUMASA , INAKOSHI MASATOSHI , NAKAMURA HIROFUMI , KOIDE TOKUO , SAKAMOTO KENICHIRO , YAMASHITA YOHEI , MIYAFUJI AKIO , SUZUKI TAKAYUKI , KAWANO NORIYUKI , MIYATA JUNJI , IMAMURA MASAKAZU , SUGANE TAKASHI
IPC分类号： C07D309/10 , C07C43/225 , C07C49/223 , C07H7/04 , C07H15/04
CPC分类号： C07C49/255 , C07C45/48 , C07C45/63 , C07C45/71 , C07C49/245 , C07H7/04 , C07H15/04
摘要： A process for producing azulene derivatives useful as Na+-glucose cotransporter inhibitor easily and simply in high yield at a low cost which is industrially advantageous and excellent in environmental protection, characterized by subjecting at least one compound selected from among specific penta- and tetraacyl precursors of the azulene derivatives and salts of the precursors to reduction and deblocking to obtain a C-glycoside compound; and useful intermediates obtained in the above process.
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4.发明公开2-CYANO-4-FLUOROPYRROLIDINE DERIVATIVE OR ITS SALT 审中-公开2-CYANO-4-FLUORPYRROLIDINDERIVAT ODER DESSEN SALZ
公开(公告)号：EP1541551A4
公开(公告)日：2007-01-24
申请号：EP03741499
申请日：2003-07-18
申请人： ASTELLAS PHARMA INC
发明人： HAYAKAWA MASAHIKO , NEGORO KENJI , MIYAMOTO SATOSHI , SUZUKI TAKAYUKI , MARUYAMA TATSUYA , NAKANO RYOSUKE
IPC分类号： C07D207/16 , A61K31/4025 , A61K31/4155 , A61K31/439 , A61K31/454 , A61K31/5377 , A61K31/541 , A61P3/10 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D451/04 , C07D471/06
CPC分类号： C07D401/12 , C07D207/16 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D451/04
摘要： It is intended to provide a compound having an excellent effect of inhibiting dipeptidylpeptidase IV, and an excellent remedy for insulin-dependent diabetes (type 1 diabetes), in particular, insulin-independent diabetes (type 2 diabetes), insulin resistance disease and obesity based on the above effect.
摘要翻译： 本发明意图提供抑制二肽基肽酶IV的优异效果的化合物以及胰岛素依赖性糖尿病（1型糖尿病），特别是胰岛素非依赖性糖尿病（2型糖尿病），胰岛素抵抗性疾病和基于肥胖症的优异的治疗剂 对上述影响。
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公开(公告)号：EP2772484A4
公开(公告)日：2015-03-25
申请号：EP12840990
申请日：2012-10-17
申请人： ASTELLAS PHARMA INC
发明人： KAWAKAMI SHIMPEI , SAKURAI MINORU , KAWANO NORIYUKI , SUZUKI TAKAYUKI , SHIRAISHI NOBUYUKI , HAMAGUCHI WATARU , SEKIOKA RYUICHI , MORITOMO HIROYUKI , MORITOMO AYAKO
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P3/10 , A61P19/10 , A61P25/04 , A61P25/18
CPC分类号： C07D237/28 , C07D231/56 , C07D239/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04
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