-
1.发明授权AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权氨基四氢萘衍生物的药物组合物阶及其治疗用途
公开(公告)号：EP2396296B1
公开(公告)日：2016-05-25
申请号：EP10706575.7
申请日：2010-02-16
发明人： AMBERG, Wilhelm , OCHSE, Michael , LANGE, Udo , KLING, Andreas , BEHL, Berthold , HORNBERGER, Wilfried , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07C215/70 , C07C311/00 , C07C317/00 , C07C233/00 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D275/02 , C07D305/08 , C07D333/04 , C07F7/10 , A61K31/16 , A61P25/00
CPC分类号： C07C311/05 , C07C215/64 , C07C217/74 , C07C233/18 , C07C233/19 , C07C233/69 , C07C255/58 , C07C271/24 , C07C307/06 , C07C309/65 , C07C311/07 , C07C311/09 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/17 , C07C311/18 , C07C311/20 , C07C311/24 , C07C317/18 , C07C317/28 , C07C2601/02 , C07C2601/04 , C07C2602/10 , C07D205/04 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/36 , C07D207/48 , C07D213/71 , C07D231/18 , C07D233/84 , C07D249/12 , C07D261/08 , C07D265/30 , C07D275/02 , C07D295/096 , C07D295/135 , C07D305/08 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07F7/0818
-
2.发明公开PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开吡咯烷，药物组合物ORDER及其在治疗中
公开(公告)号：EP2970215A1
公开(公告)日：2016-01-20
申请号：EP14710280.0
申请日：2014-03-14
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying X. , ZHAO, Hongyu H. , LI, Huan-Qiu , BREWER, Jason T. , ZANZE, Irini , DIETRICH, Justin , VASUDEVAN, Anil , DJURIC, Stevan, W. , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D207/48 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/12 , C07D207/48 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to pyrrolidine derivatives of formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
-
公开(公告)号：EP3191471B1
公开(公告)日：2020-03-11
申请号：EP15762980.9
申请日：2015-09-10
发明人： AMBERG, Wilhelm , BREWER, Jason T. , HUTCHINS, Charles , LANGE, Udo , LAO, Yanbin , LI, Huan-Qiu , POHLKI, Frauke , VASUDEVAN, Anil , WANG, Ying , ZHAO, Hongyu
IPC分类号： C07D403/12
-
4.发明公开AMINOCHROMANE, AMINOTHIOCHROMANE AND AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开氨基苯并二氢吡喃，AMINOTHIOCHROMAN-和氨基 - 1,2,3,4-四氢喹啉衍生物，药物组合物和正确使用IN THERAPY
公开(公告)号：EP3057960A1
公开(公告)日：2016-08-24
申请号：EP14790543.4
申请日：2014-10-16
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying , ZHAO, Hongyu , LI, Huan-Qiu , BREWER, Jason , VASUDEVAN, Anil , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D405/14 , C07D311/58 , C07D405/04 , A61K31/352 , A61P25/02
CPC分类号： A61K31/501 , A61K31/397 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4433 , C07D311/58 , C07D405/04 , C07D405/14
摘要： The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及药物组合物，其包括寻求氨基苯并二氢吡喃噻喃及氨基-1,2,3,4-四氢喹啉衍生物，以及使用搜索的氨基苯并二氢吡喃噻喃及氨基-1,2,3,4-四氢喹啉衍生物用于治疗目的。 的氨基苯并二氢吡喃噻喃及氨基-1,2,3,4-四氢喹啉衍生物是GlyT1抑制剂。
-
公开(公告)号：EP3057958B1
公开(公告)日：2019-05-01
申请号：EP14792415.3
申请日：2014-10-16
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying , ZHAO, Hongyu , LI, Huan-Qiu , BREWER, Jason , VASUDEVAN, Anil , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D233/42 , C07D401/12 , C07D205/04 , C07D207/273 , A61K31/4164 , A61P25/00
-
公开(公告)号：EP3057960B1
公开(公告)日：2019-02-27
申请号：EP14790543.4
申请日：2014-10-16
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying , ZHAO, Hongyu , LI, Huan-Qiu , BREWER, Jason , VASUDEVAN, Anil , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D405/14 , C07D311/58 , C07D405/04 , A61K31/352 , A61P25/02
-
7.发明公开4,5-DIHYDROPYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开4,5-二氢吡唑衍生物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：EP3191471A1
公开(公告)日：2017-07-19
申请号：EP15762980.9
申请日：2015-09-10
发明人： AMBERG, Wilhelm , BREWER, Jason T. , HUTCHINS, Charles , LANGE, Udo , LAO, Yanbin , LI, Huan-Qiu , POHLKI, Frauke , VASUDEVAN, Anil , WANG, Ying , ZHAO, Hongyu
IPC分类号： C07D403/12
摘要： The present invention relates to 4,5-dihydropyrazole derivatives of the formula (I) and physiologically tolerated salts thereof which are GlyT1 inhibitors. The invention further relates to pharmaceutical compositions comprising such 4,5-dihydropyrazole derivatives, and the use of such 4,5-dihydropyrazole derivatives for therapeutic purposes.
摘要翻译： 本发明涉及式（I）的4,5-二氢吡唑衍生物及其生理学耐受的盐，它们是GlyT1抑制剂。 本发明还涉及包含这种4,5-二氢吡唑衍生物的药物组合物，以及这种4,5-二氢吡唑衍生物用于治疗目的的用途。
-
8.发明公开N-SUBSTITUTED AMINOBENZOCYCLOHEPTENE, AMINOTETRALINE, AMINOINDANE AND PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开N-取代AMINOBENZOCYCLOHEPTEN-，AMINOTETRALIN-，AMINOINDAN- AND苯基烷基胺，含药物组合物及其用途THERAPEUTIC
公开(公告)号：EP2780328A1
公开(公告)日：2014-09-24
申请号：EP12791146.9
申请日：2012-11-19
IPC分类号： C07D233/84 , A61K31/4178 , A61P25/04 , A61P25/18
CPC分类号： C07D403/12 , C07D233/84 , C07D305/08
摘要： The present invention relates to N-substituted aminobenzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I),(II), (III) or (IV) or a physiologically tolerated salt thereof. The invention relates topharmaceutical compositions comprising such N-substituted amino-benzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives, and the use of such N-substituted aminobenzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives for therapeutic purposes. The N-substituted aminobenzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives are GlyT1 inhibitors.
-
9.发明授权
公开(公告)号：EP2970215B1
公开(公告)日：2019-04-17
申请号：EP14710280.0
申请日：2014-03-14
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying X. , ZHAO, Hongyu H. , LI, Huan-Qiu , BREWER, Jason T. , ZANZE, Irini , DIETRICH, Justin , VASUDEVAN, Anil , DJURIC, Stevan, W. , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D207/48 , A61K31/4155 , A61K31/4178 , A61K31/4439 , A61P25/00
-
公开(公告)号：EP3341369A1
公开(公告)日：2018-07-04
申请号：EP16757262.7
申请日：2016-08-26
发明人： LANGE, Udo , OCHSE, Michael , VAN DER KAM, Elizabeth , VAN BERGEIJK, Jeroen , TURNER, Sean , OELLIEN, Frank , WALLESER, Patrick , AMBERG, Wilhelm , HORNBERGER, Wilfried , GENESTE, Herve , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.03 秒)
