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公开(公告)号：EP3341369A1
公开(公告)日：2018-07-04
申请号：EP16757262.7
申请日：2016-08-26
发明人： LANGE, Udo , OCHSE, Michael , VAN DER KAM, Elizabeth , VAN BERGEIJK, Jeroen , TURNER, Sean , OELLIEN, Frank , WALLESER, Patrick , AMBERG, Wilhelm , HORNBERGER, Wilfried , GENESTE, Herve , MEZLER, Mario , HUTCHINS, Charles
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P25/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to heterocyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
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2.发明公开
公开(公告)号：EP3601255A1
公开(公告)日：2020-02-05
申请号：EP18716451.2
申请日：2018-03-20
发明人： BACKFISCH, Gisela , BAKKER, Margaretha , BLACK, Lawrence , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , KLING, Andreas , LAKICS, Viktor , MACK, Helmut , RELO, Ana Lucia , OELLIEN, Frank
IPC分类号： C07D401/12 , C07D405/12 , C07D207/16 , A61P25/24 , A61P25/14 , A61P9/00 , A61P25/22 , A61P25/28 , A61P25/18 , A61P25/30 , A61P3/10 , A61K31/40
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公开(公告)号：EP3380483A1
公开(公告)日：2018-10-03
申请号：EP16804731.4
申请日：2016-11-24
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , RELO, Ana Lucia
IPC分类号： C07D498/04 , C07D498/14 , A61K31/553 , A61P25/24
CPC分类号： C07D498/04 , A61P25/18 , A61P25/22 , A61P25/24 , C07D498/14
摘要： The present invention relates to compound of formula (I) (I) wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：EP3655392A1
公开(公告)日：2020-05-27
申请号：EP18743735.5
申请日：2018-07-16
发明人： AMBERG, Wilhelm , GENESTE, Hervé , HORNBERGER, Wilfried , LANGE, Udo , MEZLER, Mario , OCHSE, Michael , OELLIEN, Frank , TURNER, Sean C , VAN BERGEIJK, Jeroen , VAN DER KAM, Elizabeth
IPC分类号： C07D217/04 , C07D401/06 , C07D405/06 , C07D409/06 , A61P25/28 , A61K31/4725
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公开(公告)号：EP3394050A1
公开(公告)日：2018-10-31
申请号：EP16820275.2
申请日：2016-12-22
发明人： AMBERG, Wilhelm , LANGE, Udo , GENESTE, Herve , OCHSE, Michael , BIESINGER, Ralf , OELLIEN, Frank
IPC分类号： C07D405/04 , A61K31/353 , C07C211/00 , C07D205/04 , C07D207/06 , C07D265/38 , C07D211/32 , C07D413/12 , A61P25/00
CPC分类号： C07D413/12 , C07C59/72 , C07C229/30 , C07C229/36 , C07C229/46 , C07C229/48 , C07C229/50 , C07C2601/04 , C07C2601/14 , C07C2602/10 , C07C2602/38 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/16 , C07D209/52 , C07D209/94 , C07D211/32 , C07D211/62 , C07D261/12 , C07D265/36 , C07D265/38 , C07D311/04 , C07D311/58 , C07D405/04 , C07D405/14
摘要： The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
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公开(公告)号：EP3636651A1
公开(公告)日：2020-04-15
申请号：EP19212082.2
申请日：2016-11-24
发明人： BACKFISCH, Gisela , BAKKER, Margaretha Henrica Maria , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , RELO, Ana Lucia
IPC分类号： C07D498/04 , C07D498/14 , A61K31/553 , A61P25/24
摘要： The present invention relates to compound of formula (I)
wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT 2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT 2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT 2C receptor.-
公开(公告)号：EP3535244A1
公开(公告)日：2019-09-11
申请号：EP17800433.9
申请日：2017-11-02
发明人： AMBERG, Wilhelm , VAN BERGEIJK, Jeroen , GENESTE, Herve , HORNBERGER, Wilfried , VAN DER KAM, Elizabeth Louise , LANGE, Udo , MEZLER, Mario , OCHSE, Michael , OELLIEN, Frank , WALLESER, Patrick , TURNER, Sean C
IPC分类号： C07D221/20 , C07D205/12 , C07D491/107 , A61K31/397 , A61K31/438 , A61P25/00
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公开(公告)号：EP3353155A1
公开(公告)日：2018-08-01
申请号：EP16770000.4
申请日：2016-09-21
发明人： BACKFISCH, Gisela , BAKKER, Margaretha , BLAICH, Günter , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , KLING, Andreas , LAKICS, Viktor , MACK, Helmut , OELLIEN, Frank , PETER, Raimund , POHLKI, Frauke , RELO, Ana Lucia
IPC分类号： C07D241/20 , C07D213/56 , A61K31/4439 , A61K31/497 , A61P25/00
CPC分类号： C07D213/56 , C07D241/20
摘要： The present invention relates to pyridyl or pyrazinyl compounds carrying a methyl- bound N-amide moiety derived from an α-amino acid of formula I where the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, and to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of the 5-HT2C receptor.
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