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公开(公告)号：EP3993837A1
公开(公告)日：2022-05-11
申请号：EP20734426.8
申请日：2020-06-30
发明人： MARIANI, Maurizio F. , FUGAZZA, Lorenza , CHICCO, Daniela , POMPER, Martin Gilbert , RAY, Sangeeta
IPC分类号： A61K51/04 , A61P35/00 , A61K103/00 , A61K103/30
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公开(公告)号：EP3536345A1
公开(公告)日：2019-09-11
申请号：EP19169083.3
申请日：2015-05-06
发明人： RAY, Sangeeta , POMPER, Martin G. , MEADE, Thomas J. , MEASE, Ronnie C , CHEN, Ying , YANG, Xing , ROTZ, Matthew
IPC分类号： A61K51/04 , A61K49/00 , A61K49/10 , A61P35/00 , A61K49/12 , A61K51/06 , C07D257/02 , C07D403/14 , A61K103/00 , A61K103/20 , A61K103/30 , A61K103/32
摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T 1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86 Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
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3.发明公开LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), BIOLOGICAL EVALUATION, AND USE AS IMAGING AGENTS 有权前列腺特异膜抗原，标志着抑制剂（PSMA），生物学评价，并使用用作成像剂
公开(公告)号：EP2170075A2
公开(公告)日：2010-04-07
申请号：EP08779786.6
申请日：2008-06-26
CPC分类号： A61K51/0472 , A61K31/145 , A61K31/195 , A61K31/395 , A61K31/4402 , A61K38/06 , A61K51/0402 , C07D213/38 , C07D215/12 , C07D257/00 , C07D257/02 , C07F13/00 , C12Q1/37 , G01N33/57434 , G01N33/60 , G01N2500/04 , A61K2300/00
摘要： The present invention provides radiolabeled compounds of formulae (VII) and (VIII) comprising a urea derivative, a linker, a metal chelating group, and a radiolabeled or isotopically labelled metal, pharmaceutical compositions comprising such radiolabeled compounds and methods of detecting PSMA expressing tumors. The compounds of the invention are useful for providing diagnosis of cancer.
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公开(公告)号：EP3964502A1
公开(公告)日：2022-03-09
申请号：EP21198449.7
申请日：2010-03-19
发明人： POMPER, Martin G. , MEASE, Ronnie C. , RAY, Sangeeta , CHEN, Ying
IPC分类号： C07D257/00 , A61K31/41 , A61K49/00 , A61P35/00
摘要： Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
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公开(公告)号：EP3964498A1
公开(公告)日：2022-03-09
申请号：EP21198593.2
申请日：2010-03-19
发明人： POMPER, Martin G , MEASE, Ronnie C , RAY, Sangeeta , CHEN, Ying
IPC分类号： C07D209/10 , C07D311/82 , A61K31/352 , A61K49/00 , A61P35/00
摘要： Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
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公开(公告)号：EP3524277A1
公开(公告)日：2019-08-14
申请号：EP19163516.8
申请日：2012-11-30
摘要： The present invention provides a compound contains a PSMA binding Lys-Glu urea moiety linked to DOTA in complex with 111 In 3+ and its use in imaging PSMA cells.
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公开(公告)号：EP2785712B1
公开(公告)日：2019-05-01
申请号：EP12853926.9
申请日：2012-11-30
IPC分类号： A61K51/08 , A61K51/04 , C07K5/068 , C07K5/02 , C07K5/08 , C07K5/09 , C07K5/097 , A61P35/00 , C07D403/14 , C07D403/12 , A61K31/4196 , A61K38/06
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公开(公告)号：EP2408755A2
公开(公告)日：2012-01-25
申请号：EP10754194.8
申请日：2010-03-19
发明人： POMPER, Martin G. , MEASE, Ronnie C. , RAY, Sangeeta , CHEN, Ying
IPC分类号： C07D257/00 , A61K31/41 , A61K49/00 , A61P35/00
CPC分类号： C07D257/02 , A61K49/0052 , A61K51/0421 , A61K51/044 , A61K51/0446 , A61K51/0453 , A61K51/0472 , C07D209/12 , C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/20 , C07D311/82 , C07F5/027 , C07F13/005 , G01N33/5091
摘要： Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, ad tumor mapping are also described.
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公开(公告)号：EP4420730A2
公开(公告)日：2024-08-28
申请号：EP24179804.0
申请日：2010-03-19
发明人： POMPER, Martin G. , MEASE, Ronnie C. , RAY, Sangeeta , CHEN, Ying
IPC分类号： A61P35/00
CPC分类号： C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/82 , C07D257/02 , C07D209/12 , C07D311/20 , A61P35/00
摘要： Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
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公开(公告)号：EP4420730A3
公开(公告)日：2024-11-13
申请号：EP24179804.0
申请日：2010-03-19
发明人： POMPER, Martin G. , MEASE, Ronnie C. , RAY, Sangeeta , CHEN, Ying
IPC分类号： C07D257/00 , A61K31/41 , A61K49/00 , A61P35/00
摘要： Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
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