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1.发明授权LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), BIOLOGICAL EVALUATION, AND USE AS IMAGING AGENTS 有权前列腺特异膜抗原，标志着抑制剂（PSMA），生物学评价，并使用用作成像剂
公开(公告)号：EP2170075B1
公开(公告)日：2014-12-03
申请号：EP08779786.6
申请日：2008-06-26
IPC分类号： C07D213/38 , C07D215/12 , A01N47/28 , A61K31/17 , C07F13/00 , C07D257/00 , G01N33/574 , A61K31/145 , A61K31/195 , A61K31/395 , A61K51/04 , A61K31/4402 , A61K38/06
CPC分类号： A61K51/0472 , A61K31/145 , A61K31/195 , A61K31/395 , A61K31/4402 , A61K38/06 , A61K51/0402 , C07D213/38 , C07D215/12 , C07D257/00 , C07D257/02 , C07F13/00 , C12Q1/37 , G01N33/57434 , G01N33/60 , G01N2500/04 , A61K2300/00
摘要： The present invention provides radiolabeled compounds of formulae (VII) and (VIII) comprising a urea derivative, a linker, a metal chelating group, and a radiolabeled or isotopically labelled metal, pharmaceutical compositions comprising such radiolabeled compounds and methods of detecting PSMA expressing tumors. The compounds of the invention are useful for providing diagnosis of cancer.
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2.发明公开LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), BIOLOGICAL EVALUATION, AND USE AS IMAGING AGENTS 有权前列腺特异膜抗原，标志着抑制剂（PSMA），生物学评价，并使用用作成像剂
公开(公告)号：EP2170075A2
公开(公告)日：2010-04-07
申请号：EP08779786.6
申请日：2008-06-26
CPC分类号： A61K51/0472 , A61K31/145 , A61K31/195 , A61K31/395 , A61K31/4402 , A61K38/06 , A61K51/0402 , C07D213/38 , C07D215/12 , C07D257/00 , C07D257/02 , C07F13/00 , C12Q1/37 , G01N33/57434 , G01N33/60 , G01N2500/04 , A61K2300/00
摘要： The present invention provides radiolabeled compounds of formulae (VII) and (VIII) comprising a urea derivative, a linker, a metal chelating group, and a radiolabeled or isotopically labelled metal, pharmaceutical compositions comprising such radiolabeled compounds and methods of detecting PSMA expressing tumors. The compounds of the invention are useful for providing diagnosis of cancer.
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公开(公告)号：EP4192524A2
公开(公告)日：2023-06-14
申请号：EP21853121.8
申请日：2021-08-06
IPC分类号： A61K51/08 , A61K103/10 , C07K1/13 , A61K38/12 , C07K5/12
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公开(公告)号：EP2633063A2
公开(公告)日：2013-09-04
申请号：EP11837147.5
申请日：2011-10-28
CPC分类号： A61K49/0002 , A61K38/20 , A61K49/0013 , A61K49/0045 , A61K49/04 , A61K51/0491 , A61K51/0495 , C12N15/85 , C12N2710/10043 , C12Q1/6886 , C12Q1/6897 , G01N33/574
摘要： Genetic constructs comprising reporter genes operably linked to cancer specific or cancer selective promoters (such as the progression elevated gene-3 (PEG-3) promoter) are provided, as are methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. Transgenic animals in which a reporter gene is linked to a cancer specific or cancer selective promoter, and which may be further genetically engineered, bred or selected to have a predisposition to develop cancer, are also provided.
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公开(公告)号：EP2318366A2
公开(公告)日：2011-05-11
申请号：EP09803670.0
申请日：2009-07-31
CPC分类号： A61K51/0455 , A61K9/127 , A61K51/0402 , C07B2200/05 , C07C275/16 , C07C275/18 , C07D213/61 , C07D213/74 , C07D213/82 , C07F7/2212 , Y02P20/55
摘要： Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
摘要翻译： 描述了具有放射性同位素取代基的前列腺特异性膜抗原（PSMA）结合化合物及其化学前体。 化合物包括含吡啶化合物，具有苯肼结构的化合物和酰化赖氨酸化合物。 该化合物允许放射性核素准备用于单光子发射计算机断层摄影术（SPECT）和正电子发射断层摄影术（PET）用于成像，例如前列腺癌细胞和血管生成。
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