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公开(公告)号：EP2016189A2
公开(公告)日：2009-01-21
申请号：EP06847588.8
申请日：2006-12-11
申请人： Advanced Liquid Logic, Inc. , Duke University , The Board of Trustees of The Leland Stanford Junior University
发明人： POLLACK, Michael, G. , PAMULA, Vamsee, K. , ALLEN, Dwayne, J. , FAIR, Richard, B. , GRIFFIN, Peter
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the reagents for conducting a pyrosequencing protocol. The invention also includes a droplet microactuator or droplet microactuator system, having one or more input reservoirs loaded with a sample for conducting a pyrosequencing protocol.
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公开(公告)号：EP2016189B1
公开(公告)日：2012-01-25
申请号：EP06847588.8
申请日：2006-12-11
申请人： Advanced Liquid Logic, Inc. , Duke University , The Board of Trustees of the Leland Stanford Junior University
发明人： POLLACK, Michael, G. , PAMULA, Vamsee, K. , ALLEN, Dwayne, J. , FAIR, Richard, B. , GRIFFIN, Peter
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the reagents for conducting a pyrosequencing protocol. The invention also includes a droplet microactuator or droplet microactuator system, having one or more input reservoirs loaded with a sample for conducting a pyrosequencing protocol.
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公开(公告)号：EP2016091A2
公开(公告)日：2009-01-21
申请号：EP06849949.0
申请日：2006-12-11
发明人： POLLACK, Michael, G. , PAMULA, Vamsee, K. , SRINIVASAN, Vijay , PAIK, Philip, Y. , ECKHARDT, Allen, E. , FAIR, Richard, B.
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using discrete droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting biochemical reactions, such as the reagents described for use in nucleic acid amplification protocols, affinity-based assay protocols, sequencing protocols, and protocols for analyses of biological fluids.
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公开(公告)号：EP2016091B1
公开(公告)日：2010-12-08
申请号：EP06849949.0
申请日：2006-12-11
发明人： POLLACK, Michael, G. , PAMULA, Vamsee, K. , SRINIVASAN, Vijay , PAIK, Philip, Y. , ECKHARDT, Allen, E. , FAIR, Richard, B.
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using discrete droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting biochemical reactions, such as the reagents described for use in nucleic acid amplification protocols, affinity-based assay protocols, sequencing protocols, and protocols for analyses of biological fluids.
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5.发明授权METHODS AND APPARATUS FOR MANIPULATING DROPLETS BY ELECTROWETTING-BASED TECHNIQUES 有权基于电极润湿的方法和设备技术操纵液滴的
公开(公告)号：EP1554568B1
公开(公告)日：2014-10-29
申请号：EP03751751.3
申请日：2003-04-24
申请人： Duke University
IPC分类号： G01N27/403
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： A method for splitting a droplet into two or more droplets includes providing a starting droplet on a surface comprising an array of electrodes and a substantially co-planar array of reference elements. The electrode array comprises at least three electrodes comprising a first outer electrode, a medial electrode adjacent to the first outer electrode, and a second outer electrode adjacent to medial electrode. The starting droplet is initially disposed on at least one of the three electrodes and at least partially overlaps at least one other of the three electrodes. The method further includes activating each of the three electrodes to spread the starting droplet across the three electrodes, and de-activating the medial electrode to split the starting droplet into first and second split droplets. The first split droplet is thereby disposed on the first outer electrode and the second split droplet is disposed on the second outer electrode.
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6.发明授权APPARATUSES AND METHODS FOR MANIPULATING DROPLETS ON A PRINTED CIRCUIT BOARD 有权器件和方法滴在电路板上MANIPULATION
公开(公告)号：EP1859330B1
公开(公告)日：2012-07-04
申请号：EP06734056.2
申请日：2006-01-30
申请人： Duke University
CPC分类号： G01N27/44769 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502792 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0663 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/1827 , B01L2400/0415 , B01L2400/0424 , B81B3/0021 , B81B2201/058 , B81C1/00119 , C12Q1/6846 , G01N27/447 , G01N27/44791 , G05D7/0694 , H01L21/6715 , Y10T436/2575
摘要： Apparatuses and methods for manipulating droplets on a printed circuit board (PCB) are disclosed. Droplets are actuated upon a printed circuit board substrate surface by the application of electrical potentials to electrodes defined on the PCB. The use of soldermask as an electrode insulator for droplet manipulation as well techniques for adapting other traditional PCB layers and materials for droplet-based microfluidics are also disclosed.
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7.发明公开APPARATUSES AND METHODS FOR MANIPULATING DROPLETS ON A PRINTED CIRCUIT BOARD 有权器件和方法滴在电路板上MANIPULATION
公开(公告)号：EP1859330A2
公开(公告)日：2007-11-28
申请号：EP06734056.2
申请日：2006-01-30
申请人： Duke University
IPC分类号： G05D19/00
CPC分类号： G01N27/44769 , B01F13/0071 , B01F13/0076 , B01L3/502707 , B01L3/502792 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2200/12 , B01L2300/0645 , B01L2300/0663 , B01L2300/0819 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/089 , B01L2300/12 , B01L2300/1827 , B01L2400/0415 , B01L2400/0424 , B81B3/0021 , B81B2201/058 , B81C1/00119 , C12Q1/6846 , G01N27/447 , G01N27/44791 , G05D7/0694 , H01L21/6715 , Y10T436/2575
摘要： Apparatuses and methods for manipulating droplets on a printed circuit board (PCB) are disclosed. Droplets are actuated upon a printed circuit board substrate surface by the application of electrical potentials to electrodes defined on the PCB. The use of soldermask as an electrode insulator for droplet manipulation as well techniques for adapting other traditional PCB layers and materials for droplet-based microfluidics are also disclosed.
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8.发明公开METHODS AND APPARATUS FOR MANIPULATING DROPLETS BY ELECTROWETTING-BASED TECHNIQUES 有权基于电极润湿的方法和设备技术操纵液滴的
公开(公告)号：EP1554568A2
公开(公告)日：2005-07-20
申请号：EP03751751.3
申请日：2003-04-24
申请人： DUKE UNIVERSITY
IPC分类号： G01N27/403
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： A method for splitting a droplet into two or more droplets includes providing a starting droplet on a surface comprising an array of electrodes and a substantially co-planar array of reference elements. The electrode array comprises at least three electrodes comprising a first outer electrode, a medial electrode adjacent to the first outer electrode, and a second outer electrode adjacent to medial electrode. The starting droplet is initially disposed on at least one of the three electrodes and at least partially overlaps at least one other of the three electrodes. The method further includes activating each of the three electrodes to spread the starting droplet across the three electrodes, and de-activating the medial electrode to split the starting droplet into first and second split droplets. The first split droplet is thereby disposed on the first outer electrode and the second split droplet is disposed on the second outer electrode.
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