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公开(公告)号：EP3161130B1
公开(公告)日：2020-03-25
申请号：EP15811279.7
申请日：2015-06-26
发明人： STANTON, Lawrence , SATHIYANATHAN, Padmapriya , COOL, Simon , NURCOMBE, Victor , SAMSONRAJ, Rebekah M.
IPC分类号： C12N5/074 , C12N5/0735 , C12N5/0775 , A61K35/545 , C12Q1/68 , A61K35/28 , A61P19/00
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公开(公告)号：EP2334786A2
公开(公告)日：2011-06-22
申请号：EP09784536.6
申请日：2009-02-19
IPC分类号： C12N5/07 , A61K31/727 , B01D15/38 , C07K14/51
CPC分类号： A61K38/1875 , A61K31/727 , A61K31/737 , A61K35/28 , A61K2035/124 , A61L27/26 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2430/02 , B01D15/3823 , C07K14/51 , C08B37/0003 , C08B37/0075 , C12N5/0663 , C12N2501/155 , C12N2501/90
摘要： The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
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公开(公告)号：EP3004181A1
公开(公告)日：2016-04-13
申请号：EP14805119.6
申请日：2014-05-27
发明人： COOL, Simon , NURCOMBE, Victor
IPC分类号： C08B37/10 , A61K31/727 , C12N5/02 , A61F2/00
CPC分类号： C08B37/0075 , A61K31/727 , A61K38/39 , A61L27/20 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/236 , A61K2300/00
摘要： A heparan sulphate that binds vitronectin is disclosed.
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公开(公告)号：EP2324065A1
公开(公告)日：2011-05-25
申请号：EP09813323.4
申请日：2009-09-11
IPC分类号： C08B37/10 , A61P19/08 , A61K31/727 , C07K14/51
CPC分类号： A61K38/1875 , A61K31/727 , A61K31/737 , A61K35/28 , A61K2035/124 , A61L27/26 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2430/02 , B01D15/3823 , C07K14/51 , C08B37/0003 , C08B37/0075 , C12N5/0663 , C12N2501/155 , C12N2501/90
摘要： The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
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公开(公告)号：EP3242669A1
公开(公告)日：2017-11-15
申请号：EP16735241.8
申请日：2016-01-08
发明人： COOL, Simon , NURCOMBE, Victor
IPC分类号： A61K31/727 , A61P17/02 , C08B37/00
CPC分类号： C08B37/0075 , A61K31/727 , A61K38/1858 , A61K45/06 , A61L33/0011 , A61L2300/42 , A61L2400/18 , A61P17/02 , C08B37/0078 , C08B37/0081 , A61K2300/00
摘要： Affinity purification of platelet-derived growth factor-binding heparan sulphate from porcine mucosa (HS6) is disclosed. Also disclosed is the use of HS6 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
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公开(公告)号：EP3137509A1
公开(公告)日：2017-03-08
申请号：EP15786841.5
申请日：2015-04-30
发明人： COOL, Simon , NURCOMBE, Victor , LEE, Jonathan
IPC分类号： C08B37/10 , C12P19/04 , C07K14/495 , A61K31/727 , A61P19/08 , A61P17/02 , A61L27/10 , C12N5/077 , A01N1/00
CPC分类号： A61L27/20 , A01N1/0226 , A61K8/735 , A61K31/727 , A61L15/44 , A61L15/60 , A61L27/34 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2420/02 , A61L2430/06 , C07K14/495 , C08B37/0075 , C12N5/0662 , C12N2501/15 , C12N2501/91 , C08L5/10
摘要： A heparan sulphate that binds TGPβ1 is disclosed.
摘要翻译： 公开了结合TGPβ1的硫酸乙酰肝素。
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公开(公告)号：EP2997047A1
公开(公告)日：2016-03-23
申请号：EP13884688.6
申请日：2013-05-16
发明人： NURCOMBE, Victor , COOL, Simon
IPC分类号： C08B37/10 , C12P19/04 , A61K31/727 , A61P19/08
CPC分类号： C08B37/0075 , A61K9/0019 , A61K31/737 , A61K35/28 , A61K38/1825 , A61L27/20 , A61L2430/02 , C08B37/0078 , C12N5/0662 , C12N5/0663 , C12N2501/115 , C12N2501/91
摘要： A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells whilst maintaining their pluripotency/multipotency.
摘要翻译： 公开了一类结构上和功能上相关的分离的硫酸乙酰肝素。 已发现新型类肝素硫酸盐结合FGF2并增强干细胞的增殖，同时维持其多能性/多潜能性。
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公开(公告)号：EP2516628A1
公开(公告)日：2012-10-31
申请号：EP10839913.0
申请日：2010-12-22
发明人： COOL, Simon , NURCOMBE, Victor
IPC分类号： C12N5/0775 , A61K31/727 , A61L27/56 , A61F2/28 , A61K35/28 , A61P19/00
CPC分类号： A61L27/3895 , A61K35/28 , A61L27/3834 , A61L27/3847 , A61L2430/02 , C12N5/0663 , C12N2500/34
摘要： The use of mesenchymal stem cells cultured in the presence of HS-2 for the treatment of bone fracture. Repair of bone fracture using such cells is enhanced compared with the treatment of bone fracture using mesenchymal cells cultured without HS-2. These mesenchymal stem cells may be formulated in a pharmaceutical composition and injected directly into tissues surrounding the fracture or used in a biocompatible implant or prosthesis.
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公开(公告)号：EP3724238A1
公开(公告)日：2020-10-21
申请号：EP18888625.3
申请日：2018-12-11
IPC分类号： C08B37/10 , A61K31/727 , A61P19/08
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公开(公告)号：EP3004181B1
公开(公告)日：2019-01-02
申请号：EP14805119.6
申请日：2014-05-27
发明人： COOL, Simon , NURCOMBE, Victor
IPC分类号： C08B37/10 , A61K31/727 , C12N5/02 , A61F2/00
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