公开(公告)号：EP2188252B1

公开(公告)日：2011-04-13

申请号：EP08831946.2

申请日：2008-09-19

申请人： Amgen Inc. ,  EPIX Pharmaceuticals, Inc.

发明人： NEIRA, Susana, C. ,  YU, Xiang ,  BURLI, Roland ,  LANMAN, Brian ,  CEE, Victor

IPC分类号： C07D205/04 ,  A61K31/397 ,  A61P37/06 ,  C07D401/10 ,  A61K31/4427

CPC分类号： C07D205/04 ,  C07D401/10

摘要： The present invention relates to amides that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non- glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

公开(公告)号：EP2121648A2

公开(公告)日：2009-11-25

申请号：EP07753654.8

申请日：2007-03-21

申请人： EPIX Pharmaceuticals, Inc.

发明人： SAHA, Ashis ,  YU, Xiang, Y. ,  LOBERA, Mercedes ,  LIN, Jian ,  CHERUKU, Srinivasa, R. ,  BECKER, Oren ,  MARANTZ, Yael ,  SCHUTZ, Nili ,  BURLI, Roland ,  CEE, Victor, J. ,  GOLDEN, Jennifer ,  LANMAN, Brian, Alan ,  NEIRA, Susana ,  ORBACH, Pini ,  McCAULEY, Dilara. ,  SHARADENDU, Anurag. ,  SHACHAM, Sharon. ,  PENLAND, Robert.C. ,  NOIMAN, Silvia. ,  GANNON, Kimberley. ,  ZHANG, Zhaoda.

IPC分类号： C07D307/81 ,  C07D405/10 ,  C07D405/04 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10 ,  C07D471/04 ,  C07D491/04

CPC分类号： C07D491/048 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

公开(公告)号：EP2142509B1

公开(公告)日：2013-12-04

申请号：EP08743008.8

申请日：2008-04-16

申请人： Amgen, Inc

发明人： ALLEN, Jennifer, R. ,  BURLI, Roland ,  BRYAN, Marian, C. ,  CAO, Guo-Qiang ,  NEIRA, Susana, C. ,  REED, Anthony, B.

IPC分类号： C07D215/22 ,  C07D405/04 ,  C07D409/04 ,  C07D471/04 ,  A61K31/435 ,  A61K31/4375 ,  A61P7/06

CPC分类号： C07D471/04 ,  C07D215/22 ,  C07D405/04 ,  C07D409/04

公开(公告)号：EP2150251B9

公开(公告)日：2013-02-27

申请号：EP08767502.1

申请日：2008-04-29

申请人： Amgen, Inc

发明人： ALLEN, Jennifer R. ,  BURLI, Roland ,  FROHN, Michael J. ,  HUNGATE, Randall W. ,  NEIRA, Susana C. ,  REED, Anthony B.

IPC分类号： C07D495/04 ,  C07D513/04 ,  A61K31/4365 ,  A61K31/437 ,  A61P7/06 ,  A61P9/10

CPC分类号： A61K31/4365 ,  A61K31/437 ,  C07D495/04 ,  C07D513/04

公开(公告)号：EP2155680A1

公开(公告)日：2010-02-24

申请号：EP08742727.4

申请日：2008-04-09

申请人： Amgen, Inc

发明人： ALLEN, Jennifer R. ,  BURLI, Roland ,  GOLDEN, Jennifer E. ,  MULLER, Kristine M. ,  REED, Anthony B.

IPC分类号： C07D213/16 ,  C07D309/04 ,  C07D333/10 ,  C07C15/24 ,  C07C235/04 ,  A61K31/44 ,  A61K31/381

CPC分类号： C07D213/16 ,  C07D213/56 ,  C07D309/04 ,  C07D309/06 ,  C07D333/10 ,  C07D333/24

摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

公开(公告)号：EP1991530A1

公开(公告)日：2008-11-19

申请号：EP07751202.8

申请日：2007-02-20

申请人： Amgen Inc. ,  Memory Pharmaceuticals Corporation

发明人： ARRINGTON, Mark, P. ,  LIU, Ruiping ,  HOPPER, Allen, T. ,  CONTICELLO, Richard, D. ,  NGUYEN, Truc, M. ,  GAUSS, Carla, Maria ,  BURLI, Roland ,  HITCHCOCK, Stephen, A. ,  HU, Essa ,  KUNZ, Roxanne ,  NIXEY, Thomas ,  RUMFELT, Shannon

IPC分类号： C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/10 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10

CPC分类号： C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/10 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

摘要： The present invention is directed tojcjnnoline compounds of formula (I) that are PDE 1 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. This invention is also directed to methods of treating diseases treatable by inhibition of PDElO enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 本发明涉及作为PDE1抑制剂的式（I）的炔丙醇化合物，含有此类化合物的药物组合物以及制备此类化合物的方法。 本发明还涉及治疗通过抑制PDE10酶如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相型障碍，强迫性障碍等可治疗的疾病的方法。

公开(公告)号：EP1960363A2

公开(公告)日：2008-08-27

申请号：EP06844992.5

申请日：2006-12-08

申请人： Amgen, Inc.

发明人： ALLEN, Jennifer R. ,  TEGLEY, Christopher M. ,  BISWAS, Kaustav ,  BURLI, Roland ,  MULLER, Kristine M. ,  FROHN, Michael J. ,  GOLDEN, Jennifer E. ,  MERCEDE, Stephanie J. ,  NEIRA, Susana C. ,  PETERKIN, Tanya A. N. ,  HUNGATE, Randall W. ,  KURZEJA, Robert ,  YU, Violeta ,  DAO, Jennifer

IPC分类号： C07D215/22

CPC分类号： C07D215/22 ,  C07D215/56 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  G01N33/542

摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.

公开(公告)号：EP2155680B1

公开(公告)日：2013-12-04

申请号：EP08742727.4

申请日：2008-04-09

申请人： Amgen, Inc

发明人： ALLEN, Jennifer R. ,  BURLI, Roland ,  GOLDEN, Jennifer E. ,  MULLER, Kristine M. ,  REED, Anthony B.

IPC分类号： C07D213/16 ,  C07D309/04 ,  C07D333/10 ,  C07C15/24 ,  C07C235/04 ,  A61K31/44 ,  A61K31/381

CPC分类号： C07D213/16 ,  C07D213/56 ,  C07D309/04 ,  C07D309/06 ,  C07D333/10 ,  C07D333/24

公开(公告)号：EP2155746A2

公开(公告)日：2010-02-24

申请号：EP08767526.0

申请日：2008-05-02

申请人： Amgen, Inc

发明人： ALLEN, Jennifer R. ,  BISWAS, Kaustav ,  BURLI, Roland ,  GOLDEN, Jennifer E. ,  MERCEDE, Stephanie ,  TEGLEY, Christopher M.

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/5377 ,  A61P7/06

CPC分类号： C07D471/04

摘要： Compounds of Formula (I) are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure where the definitions of the variables are provided herein.

公开(公告)号：EP2150251A1

公开(公告)日：2010-02-10

申请号：EP08767502.1

申请日：2008-04-29

申请人： Amgen, Inc

发明人： ALLEN, Jennifer R. ,  BURLI, Roland ,  FROHN, Michael J. ,  HUNGATE, Randall W. ,  NEIRA, Susana C. ,  REED, Anthony B.

IPC分类号： A61K31/4365 ,  A61K31/437 ,  A61P7/06 ,  A61P9/10 ,  A61P9/12 ,  A61P3/10 ,  A61P17/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D495/04 ,  C07D513/04

CPC分类号： A61K31/4365 ,  A61K31/437 ,  C07D495/04 ,  C07D513/04

摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure:(I) where the definitions of the variables are provided herein.