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1.发明公开QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS 有权CHINAZOLINVERBINDUNGEN ALS SERIN- / THREONINKINASEHEMMER
公开(公告)号：EP2739618A1
公开(公告)日：2014-06-11
申请号：EP12769775.3
申请日：2012-08-03
发明人： BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
IPC分类号： C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D405/14 , C07D403/12
摘要： Compounds having the formula (I) wherein R
1 , R
2 , R
3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.-
公开(公告)号：EP2739618B1
公开(公告)日：2015-09-16
申请号：EP12769775.3
申请日：2012-08-03
发明人： BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
IPC分类号： C07D405/14 , C07D403/12 , C07D413/14 , A61K31/517 , A61P35/00
CPC分类号： C07D405/14 , C07D403/12
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公开(公告)号：EP2990407A1
公开(公告)日：2016-03-02
申请号：EP15175131.0
申请日：2009-05-13
发明人： LE HUEROU, Yvan , BLAKE, James, F. , GUNWARDANA, Indrani, W. , MOHR, Peter, J. , WALLACE, Eli, M. , WANG, Bin , CHICARELLI, Mark , LYON, Michael
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式I化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：EP1663210A1
公开(公告)日：2006-06-07
申请号：EP04781809.1
申请日：2004-08-20
发明人： WALLACE, Eli, M. , LYSSIKATOS, Joseph, P. , MARLOW, Allison, L. , HURLEY, Brian, T. , KOCH, Kevin
IPC分类号： A61K31/4184 , C07D235/08
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9, and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP1482944A2
公开(公告)日：2004-12-08
申请号：EP03716498.5
申请日：2003-03-13
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4184 , C07D413/02 , C07D403/02 , C07D235/14
CPC分类号： C07D235/06 , C07D401/06 , C07D403/06
摘要： Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R1, R2, R7, R9, R10, R11 and R12 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP2990407B1
公开(公告)日：2019-10-16
申请号：EP15175131.0
申请日：2009-05-13
发明人： LE HUEROU, Yvan , BLAKE, James, F. , GUNWARDANA, Indrani, W. , MOHR, Peter, J. , WALLACE, Eli, M. , WANG, Bin , CHICARELLI, Mark , LYON, Michael
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP2307409B1
公开(公告)日：2015-08-12
申请号：EP09747404.3
申请日：2009-05-13
发明人： LE HUEROU, Yvan , BLAKE, James, F. , GUNWARDANA, Indrani, W. , MOHR, Peter, J. , WALLACE, Eli, M. , WANG, Bin , CHICARELLI, Mark , LYON, Michael
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2081918A2
公开(公告)日：2009-07-29
申请号：EP07843704.3
申请日：2007-10-03
发明人： AHRENDT, Kateri , DELISLE, Robert, Kirk , HANS, Jeremy , LYSSIKATOS, Joseph, P. , ROBINSON, John, E. , WALLACE, Eli, M. , ZHAO, Qian
IPC分类号： C07D285/12 , C07D413/06 , C07D413/12 , A61K31/433 , A61P35/00
CPC分类号： C07D285/12 , C07D413/06 , C07D413/12
摘要： This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment of various disorders.
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公开(公告)号：EP1482932A1
公开(公告)日：2004-12-08
申请号：EP03714148.8
申请日：2003-03-13
IPC分类号： A61K31/4184 , C07D235/04 , C07D235/06
CPC分类号： C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
摘要： Disclosed are compounds of the formula I, and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1 , R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
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公开(公告)号：EP2678329A1
公开(公告)日：2014-01-01
申请号：EP12716770.8
申请日：2012-02-24
发明人： BLAKE, James, F , DELISLE, Robert, Kirk , DE MEESE, Lisa, A. , GRAHAM, James, M. , LE HUEROU, Yvan , LYON, Michael , ROBINSON, John, E. , WALLACE, Eli, M. , WANG, Bin , XU, Rui
IPC分类号： C07D401/06 , C07D471/04 , C07D519/00 , A61K31/4709 , A61P29/00
CPC分类号： C07D471/04 , C07D401/06 , C07D487/04 , C07D487/10 , C07D491/048 , C07D519/00
摘要： Compounds of Formula I: in which R
1 , R
2 , R
3 , R
4 and R
10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
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