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1.发明授权COMPOSES TRICYCLIQUES AYANT UNE ACTIVITE VIS-A-VIS DES INTEGRINES NOTAMMENT VIS-A-VIS DE L'INTEGRINE ALPHA vBETA3, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES DE CE PROCEDE, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT 失效WITH对整TRIZYCLISCHE TIES，特别是在素αVβ3整联蛋白，生产和诉讼的中间产品的方法，它们作为包含新药与YOU药物组合物
公开(公告)号：EP0888292B1
公开(公告)日：2001-10-31
申请号：EP97915519.9
申请日：1997-03-20
发明人： BERNARD, Serge , CARNIATO, Denis , GOURVEST, Jean-François , TEUTSCH, Jean-Georges , KNOLLE, Jochen , STILZ, Hans-Ulrich , WEHNER, Volkmar , BODARY, Sarah, C. , GADEK, Thomas, R. , MCDOWELL, Robert, S. , PITTI, Robert, M.
IPC分类号： C07C281/12 , C07D233/52 , C07C337/08 , C07D239/18 , C07D317/70 , A61K31/19 , A61K31/415 , A61K31/505 , A61K31/36
CPC分类号： C07D239/18 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/71 , C07C49/747 , C07C49/755 , C07C281/12 , C07C281/18 , C07C331/04 , C07C331/10 , C07C331/12 , C07C331/14 , C07C337/08 , C07C2603/30 , C07D233/52 , Y02P20/55 , C07C49/753
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2.发明公开DERIVES D'IMINOGUANIDINES, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION COMME MEDICAMENTS 有权IMINOGUANIDINE衍生物，生产与应用，药物
公开(公告)号：EP1133476A1
公开(公告)日：2001-09-19
申请号：EP99956122.8
申请日：1999-11-23
发明人： CARNIATO, Denis,Résidence Le Samoa Entrée B , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , RUXER, Jean-Marie , BODARY, Sarah, C.
IPC分类号： C07D233/52 , C07C281/18 , A61K31/4168 , A61K31/155 , A61P19/10
CPC分类号： C07C281/18 , C07D233/52
摘要： The invention concerns compounds of formula (I) wherein: m = 1, 2 or 3; n = 1, 2 or 3; R5 represents a group selected among COR6, CO2R6, SO2R6, SO2NHR6, SO2NHCOR6, SO2NHCO2R6, CONH2, CONHR6; R1, R2, R4, R6, R7 R8 and R12 are as defined in the description, in all their possible isomeric forms, their physiologically acceptable salts, their prodrugs. The invention also concerns the method for preparing them, their use as medicines in particular for treating osteoporosis and the pharmaceutical compositions containing them.
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3.发明授权
公开(公告)号：EP1133478B1
公开(公告)日：2016-01-06
申请号：EP99956120.2
申请日：1999-11-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , RUXER, Jean-Marie , BODARY, Sarah, C.
IPC分类号： C07D239/16 , C07C279/22 , C07C311/06 , A61K31/505
CPC分类号： C07D239/16 , C07C279/22 , C07C311/06
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4.发明授权
公开(公告)号：EP1133491B1
公开(公告)日：2003-02-19
申请号：EP99956121.0
申请日：1999-11-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , BODARY, Sarah, C.
IPC分类号： C07D405/12 , A61K31/495
CPC分类号： C07D405/12
摘要： The invention concerns compounds of formula (I) wherein: m = 1, 2 or 3; n = 1, 2 or 3; R5 represents a group selected among COR6, CO2R6, SO2R6, SO2NHR6, SO2NHCOR6, SO2NHCO2R6, CONH2 and CONHR6; R1, R2, R4, R5, R6 and R7 are as defined in the description, in all their possible isomeric forms, their physiologically acceptable salts, their prodrugs. The invention also concerns the method for preparing them, their use as medicines in particular for treating osteoporosis and pharmaceutical compositions containing them.
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公开(公告)号：EP0865446B1
公开(公告)日：2007-03-21
申请号：EP96942315.1
申请日：1996-12-06
申请人： Aventis Pharma S.A.
发明人： KITAMURA, Kazuyuki , KOMIYAMA, Osamu , INAZU, Mizuho , BARON, Roland , GADEK, Thomas , KNOLLE, Jochen , STILZ, Han-Ulrich , WEHNER, Volkmar , MCDOWELL, Robert, S.
IPC分类号： C07K7/06 , C07K14/705 , A61K38/04
CPC分类号： C07K5/0821 , A61K38/04 , A61K38/05 , A61K38/07 , A61K38/12 , A61K38/1703 , A61K38/39 , C07C271/22 , C07C279/08 , C07C279/20 , C07K5/0202 , C07K5/0817 , C07K5/1019 , C07K5/1024 , C07K14/46 , C07K14/745 , C07K14/78
摘要： The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by general formula (IX) and so on, as well as a biologically acceptable salt thereof, wherein R16 represents -N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents -NH-, -O- or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.
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6.发明授权DERIVES D'HYDRAZONO-BENZAZULENE, COMPOSITIONS PHARMACEUTIQUES ET INTERMEDIAIRES 有权肼基benzazulene衍生物，药物组合物和中间产品
公开(公告)号：EP1017681B1
公开(公告)日：2003-04-09
申请号：EP98945363.4
申请日：1998-09-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOUBET, François , GOURVEST, Jean-François , KNOLLE, Jochen , MCDOWELL, Robert , SCHEUNEMANN, Karl-Heinz
IPC分类号： C07D233/52 , A61K31/415 , C07C49/747 , C07C333/04 , C07C323/22
CPC分类号： C07C333/04 , C07C49/747 , C07C323/22 , C07D233/52
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7.发明授权DERIVES D'IMINOGUANIDINES, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION COMME MEDICAMENTS 有权IMINOGUANIDINE衍生物，生产与应用，药物
公开(公告)号：EP1133476B1
公开(公告)日：2006-08-02
申请号：EP99956122.8
申请日：1999-11-23
发明人： CARNIATO, Denis, Résidence Le Samoa Entrée B , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , RUXER, Jean-Marie , BODARY, Sarah, C.
IPC分类号： C07D233/52 , C07C281/18 , A61K31/4168 , A61K31/155 , A61P19/10
CPC分类号： C07C281/18 , C07D233/52
摘要： The invention concerns compounds of formula (I) wherein: m = 1, 2 or 3; n = 1, 2 or 3; R5 represents a group selected among COR6, CO2R6, SO2R6, SO2NHR6, SO2NHCOR6, SO2NHCO2R6, CONH2, CONHR6; R1, R2, R4, R6, R7 R8 and R12 are as defined in the description, in all their possible isomeric forms, their physiologically acceptable salts, their prodrugs. The invention also concerns the method for preparing them, their use as medicines in particular for treating osteoporosis and the pharmaceutical compositions containing them.
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8.发明公开
公开(公告)号：EP1157028A1
公开(公告)日：2001-11-28
申请号：EP00906440.3
申请日：2000-02-21
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , BODARY, Sarah, C.
IPC分类号： C07J41/00 , A61K31/565 , A61K31/58
CPC分类号： C07J41/0005
摘要： The invention concerns compounds of formula (I) wherein: X, Y, R1, R2, Z, G are as defined in the description, the methods for preparing them and the intermediates in said method, their use as medicine and the pharmaceutical compositions containing them.
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9.发明公开
公开(公告)号：EP1133478A1
公开(公告)日：2001-09-19
申请号：EP99956120.2
申请日：1999-11-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , RUXER, Jean-Marie , BODARY, Sarah, C.
IPC分类号： C07D239/16 , C07C279/22 , C07C311/06 , A61K31/505
CPC分类号： C07D239/16 , C07C279/22 , C07C311/06
摘要： The invention concerns compounds of formula (I) wherein: m = 1, 2 or 3; n = 1, 2 or 3; R5 represents a group selected among COR6, CO2R6, SO2R6, SO2NHR6, SO2NHCOR6, SO2NHCO2R6, CONH2 and CONHR6; R1, R2, R4, R6, R7 and R8 are as defined in the description, in all their possible isomeric forms, their physiologically acceptable salts, their prodrugs. The invention also concerns the method for preparing them, their use as medicines in particular for treating osteoporosis and the pharmaceutical compositions containing them.
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10.发明授权COMPOSES TRICYCLIQUES, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES DE CE PROCEDE, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT 有权DREIRINGIGE化合物的方法，为自己的产品，这个过程之间，其应用药物和你的药物组合物含
公开(公告)号：EP1017680B1
公开(公告)日：2007-02-07
申请号：EP98945362.6
申请日：1998-09-23
发明人： CARNIATO, Denis , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , McDOWELL, Robert , PEYMAN, Anuschirwan
IPC分类号： C07D233/52 , C07D233/50 , C07D239/18 , C07D239/14 , C07D401/12 , C07D407/12 , C07C69/76 , C07C69/003 , C07C65/40 , C07C235/84 , C07C271/22 , A61K31/415 , A61K31/505
CPC分类号： C07D239/42 , C07D233/52 , C07D401/12 , C07D405/12
摘要： The invention concerns products of formula (I) in which R1 represents -CONH - [A] - [B] -COR6, [A], [B]; R2, R3, R4, R5 and G are as defined in the description, and their salt additives with acids, bases and esters, the method for preparing them and the intermediates of said method, their application as medicines and the pharmaceutical compositions containing them.
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