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1.发明公开MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS 审中-公开吗啉和四氢衍生物及其作为抑制剂CATHEPSIN
公开(公告)号：EP1515726A1
公开(公告)日：2005-03-23
申请号：EP03739296.6
申请日：2003-06-25
发明人： GRAUPE, Michael , PALMER, James, T. , PATTERSON, John, W. , PICKETT, Stephen, D. , ALDOUS, David, J. , THURAIRATNAM, Sukanthini , TIMM, Andreas, P. , HALLEY, Frank , LAI, Justine , LINK, John , LI, Jiayao
IPC分类号： A61K31/5375 , C07D271/06 , C07D263/56 , C07D413/12 , C07D498/04 , C07D213/40 , C07D295/185 , A61K31/5377 , A61K31/4245
CPC分类号： C07D213/40 , A61K31/4245 , A61K31/5375 , A61K31/5377 , C07C317/44 , C07C323/60 , C07D205/08 , C07D207/24 , C07D213/75 , C07D223/12 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D277/26 , C07D277/64 , C07D285/08 , C07D295/185 , C07D413/04 , C07D413/12
摘要： The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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公开(公告)号：EP1383748A2
公开(公告)日：2004-01-28
申请号：EP01988420.4
申请日：2001-12-24
发明人： GRAUPE, Michael , PATTERSON, John , PICKETT, Stephen, D. , LINK, John , LI, Jiayao , ALDOUS, David , THURAIRATNAM, Sukanthini , TIMM, Andreas , HALLEY, Frank , LAI, Justine
IPC分类号： C07D263/56 , C07D277/64 , C07D295/18 , C07C317/44 , C07D271/06 , C07C323/60 , C07D205/08 , C07D277/26 , C07C317/50 , C07D207/26 , C07D233/10 , C07D498/04 , C07D271/10 , C07D413/04 , C07D223/12 , A61K31/16 , A61P29/00
CPC分类号： C07D207/273 , A61K31/5375 , A61K31/5377 , C07C317/44 , C07C323/60 , C07D205/08 , C07D207/24 , C07D213/40 , C07D223/10 , C07D223/12 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D277/26 , C07D277/64 , C07D285/08 , C07D295/185 , C07D413/04 , C07D413/12 , Y02A50/411
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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3.发明公开SUBSTITUTED 1H-PYRROLO 3,2-B, 3,2-C, AND 2,3-C¨PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 有权取代的1H-吡咯并[3,2-B，3,2-C和2,3- C]吡啶-2-羧酰胺和相关类似物如酪蛋白激酶I-EPSILON的抑制剂
公开(公告)号：EP1747220A1
公开(公告)日：2007-01-31
申请号：EP04812567.8
申请日：2004-12-01
发明人： METZ, William, A. , HALLEY, Frank , DUTRUC-ROSSET, Gilles , CHOI-SLEDESKI, Yong, Mi , POLI, Gregory, B. , FINK, David, M. , DOERFLINGER, Gilles , HUANG, Bao-Guo , GELORMINI, Ann, Marie , GAMBOA, Juan, A. , GIOVANNI, Andrew , ROEHR, Joachim, E. , TSAY, Joseph, T. , CAMACHO, Fernando , HURST, William, J. , HARNISH, Stephen, W. , CHIANG, Yulin
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
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4.发明授权SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 有权取代的1H-吡咯并[3,2-B，3,2-C和2,3- C]吡啶-2-羧酰胺和相关类似物如酪蛋白激酶I-EPSILON的抑制剂
公开(公告)号：EP1747220B1
公开(公告)日：2009-04-15
申请号：EP04812567.8
申请日：2004-12-01
发明人： METZ, William, A. , HALLEY, Frank , DUTRUC-ROSSET, Gilles , CHOI-SLEDESKI, Yong, Mi , POLI, Gregory, B. , FINK, David, M. , DOERFLINGER, Gilles , HUANG, Bao-Guo , GELORMINI, Ann, Marie , GAMBOA, Juan, A. , GIOVANNI, Andrew , ROEHR, Joachim, E. , TSAY, Joseph, T. , CAMACHO, Fernando , HURST, William, J. , HARNISH, Stephen, W. , CHIANG, Yulin
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
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