专利检索 ap:("BARNES JEWISH HOSPITAL" OR "DOW CHEMICAL CO") AND inv:"WICKLINE SAMUEL A" 第 1 页

1.

发明公开
CHELATING AGENTS WITH LIPOPHILIC CARRIERS 审中-公开
标题翻译：螯合剂具有亲脂性载体

公开(公告)号：EP1594550A4

公开(公告)日：2007-07-11

申请号：EP04705340

申请日：2004-01-26

申请人： BARNES JEWISH HOSPITAL , DOW CHEMICAL CO

发明人： LANZA GREGORY M , WICKLINE SAMUEL A , ATHEY PHILLIP S , GULYAS GYONGYI , KIEFER GARRY E

IPC分类号： A61K49/18 , C07F9/10

CPC分类号： C07F9/10 , A61K49/103 , A61K49/1806

摘要： Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.

2.

发明公开
IMPROVED EFFICACY AND SAFETY OF TARGETED PARTICULATE AGENTS WITH DECOY SYSTEMS 审中-公开
标题翻译：改进效率和诱饵的系统为目标TELCHENFÖRMIGEN资金安全

公开(公告)号：EP1720521A4

公开(公告)日：2008-11-05

申请号：EP05749878

申请日：2005-02-10

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY M , WICKLINE SAMUEL A

IPC分类号： A61K9/127 , A61K9/14 , A61K9/51 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12

CPC分类号： A61K9/1075 , A61K9/127 , A61K49/0002 , A61K51/1234 , A61K51/1244 , B82Y5/00

3.

发明公开
BLOOD CLOT-TARGETED NANOPARTICLES 审中-公开
标题翻译：血液凝块纳米展望

公开(公告)号：EP1539252A4

公开(公告)日：2008-03-12

申请号：EP03793255

申请日：2003-08-20

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY , WICKLINE SAMUEL A

IPC分类号： A61K51/00 , G01T1/161 , A61B5/055 , A61B8/00 , A61B8/06 , A61K20060101 , A61K9/107 , A61K9/14 , A61K47/06 , A61K47/30 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/16 , A61K49/18 , A61K49/22 , A61K51/08 , A61K51/10 , A61K51/12

CPC分类号： A61K51/1227 , A61K47/6843 , A61K47/6907 , A61K49/0471 , A61K49/1806 , A61K49/1812 , A61K49/227 , B82Y5/00

4.

发明公开
EMULSION PARTICLES FOR IMAGING AND THERAPY AND METHODS OF USE THEREOF 审中-公开
标题翻译：对于图片乳液中的颗粒和治疗及其使用方法

公开(公告)号：EP1651276A4

公开(公告)日：2009-05-06

申请号：EP04780338

申请日：2004-08-06

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY M , WICKLINE SAMUEL A

IPC分类号： A61K49/04 , A61B5/055 , A61K49/00 , A61K51/00

CPC分类号： B82Y5/00 , A61K49/049

5.

发明公开
ENHANCED DRUG DELIVERY 审中-公开
标题翻译：改良药品CHARGE

公开(公告)号：EP1684724A4

公开(公告)日：2008-04-02

申请号：EP04811756

申请日：2004-11-19

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY M , WICKLINE SAMUEL A

IPC分类号： A61K9/00 , A61K20060101 , A61K9/127 , A61K9/51 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/04

CPC分类号： A61K9/0009 , A61K9/1075 , A61K41/0047 , A61K47/6909 , A61K51/0408 , A61K51/1227

6.

发明公开
INTEGRIN TARGETED IMAGING AGENTS 审中-公开
标题翻译：目标整联蛋白试剂FOR IMAGING

公开(公告)号：EP1572639A4

公开(公告)日：2006-08-09

申请号：EP03707550

申请日：2003-01-24

申请人： BARNES JEWISH HOSPITAL , BRISTOL MYERS SQUIBB MEDICAL I

发明人： LANZA GREGORY , WICKLINE SAMUEL A , HARRIS TOM

IPC分类号： A61K47/22 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/18 , A61K51/00 , A61B5/055 , A61B8/00 , C07D413/00

CPC分类号： A61K49/223 , A61K47/6907 , A61K49/0002 , A61K49/1833 , B82Y5/00

7.

发明公开
SITE SPECIFIC BINDING SYSTEM, IMAGING COMPOSITIONS AND METHODS 失效
标题翻译：局部特定绑定系统PICTURES令人信服的组合物和方法

公开(公告)号：EP0831933A4

公开(公告)日：2001-05-30

申请号：EP96919451

申请日：1996-06-06

申请人： BARNES JEWISH HOSPITAL D B A

发明人： LANZA GREGORY M , WICKLINE SAMUEL A

IPC分类号： G01R33/28 , A61B5/055 , A61B8/06 , A61K9/107 , A61K9/127 , A61K49/00 , A61K49/04 , A61K49/18 , A61K51/00 , A61K51/12 , G01N33/58 , C07K1/00 , C12P13/18 , G01N33/53

CPC分类号： A61K49/18 , A61K49/1812 , G01N33/586 , Y10S514/937

8.

发明公开
DETECTION AND IMAGING OF TARGET TISSUE 审中-公开
标题翻译：检测级和目标组织的成像

公开(公告)号：EP2019667A4

公开(公告)日：2012-08-22

申请号：EP07761521

申请日：2007-04-27

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY M , WICKLINE SAMUEL A

IPC分类号： A61K9/127 , A61B5/055 , A61K49/18 , A61K51/12

CPC分类号： A61K49/1809 , A61K49/0041 , A61K49/0082 , A61K49/0093 , A61K51/122

9.

发明公开
SITE SPECIFIC BINDING SYSTEM, NUCLEAR IMAGING COMPOSITIONS AND METHODS 审中-公开
标题翻译： TARGET特异性结合体系，核成像组合物及方法

公开(公告)号：EP1251877A4

公开(公告)日：2009-07-22

申请号：EP99924489

申请日：1999-05-25

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY M , WICKLINE SAMUEL A

IPC分类号： A61K49/18 , G01R33/28 , A61B5/055 , A61B8/06 , A61K9/107 , A61K9/127 , A61K49/00 , A61K49/04 , A61K51/00 , A61K51/12 , G01N33/58

CPC分类号： A61K49/18 , A61K49/1812 , A61K51/1217 , A61K51/1234 , G01N33/586

摘要： A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance, positron emission tomography or nuclear imaging. Compositions for use in ultrasonic imaging of nature or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.

10.

发明公开
ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS 审中-公开
标题翻译：与温度相关的造影剂改进的超声检测

公开(公告)号：EP1363538A4

公开(公告)日：2009-05-13

申请号：EP02706070

申请日：2002-01-30

申请人： BARNES JEWISH HOSPITAL

发明人： LANZA GREGORY M , WICKLINE SAMUEL A , HALL CHRISTOPHER S

IPC分类号： G01R33/28 , A61B5/055 , A61B8/00 , A61K9/133 , A61K49/00 , A61K49/04 , A61K49/22 , A61K51/00 , A61B5/05 , A61B5/06 , A61K9/127 , A61K9/14

CPC分类号： A61K49/223 , A61K49/226 , Y10S514/937 , Y10S514/938

摘要： Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.