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1.发明授权SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权SUBSTANZ ZUR WIEDERHERSTELLUNG DER NORMALEN CO-EXPRESSION UND INTEREKTION ZWISCHEN LOX-UND NRAGE-PROTEINEN
公开(公告)号：EP1948128B1
公开(公告)日：2017-03-15
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61Q19/08 , A61K36/77 , A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
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公开(公告)号：EP2170259B1
公开(公告)日：2018-09-05
申请号：EP08774551.9
申请日：2008-06-30
CPC分类号： A61K8/602 , A61K8/41 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K31/132 , A61K2800/51 , A61Q19/06
摘要： This invention relates to the use of a preparation comprising sulfated oligosaccharides which trap spermine and/or spermidine, as an active slimming ingredient in a cosmetic, pharmaceutical and/or nutraceutical composition. One aspect of the invention is to supply a cosmetic, pharmaceutical or nutriceutical composition with a slimming effect.
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公开(公告)号：EP2157978A2
公开(公告)日：2010-03-03
申请号：EP08760699.2
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
IPC分类号： A61K36/14 , A61K8/97 , A61Q19/08 , A61P17/00 , A61K31/437
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the μ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
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公开(公告)号：EP2170358A2
公开(公告)日：2010-04-07
申请号：EP08786013.6
申请日：2008-07-09
IPC分类号： A61K36/00 , A61K31/136 , A61K31/192 , A61K31/353 , A61K31/404 , A61K31/407 , A61K31/60 , A61K8/35 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/97 , A61P3/10 , A61P17/00 , A61Q19/08 , A23L1/29 , G01N33/68
CPC分类号： G01N33/6803 , A61K8/347 , A61K8/365 , A61K8/368 , A61K8/415 , A61K8/492 , A61K8/498 , A61K8/97 , A61K31/05 , A61K31/136 , A61K31/185 , A61K31/192 , A61K31/353 , A61K31/404 , A61K31/407 , A61K31/60 , A61K36/00 , A61Q19/08 , A61K2300/00
摘要： The invention relates to the use, as active ingredient, of at least one substance that promotes AGE deglycation, for the preparation of a composition, especially for limiting the presence of AGEs in a tissue. The invention relates in particular to the use of such a substance for the preparation of a composition for use in preventing and/or combating the decrease in flexibility and/or plasticity and/or elasticity and/or functionality of a tissue, and/or in preventing and/or combating ageing of a tissue, by promoting AGE deglycation in the tissue, wherein said tissue is preferably the skin, or the tissue wall of a blood vessel or of an organ.
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公开(公告)号：EP2170307A2
公开(公告)日：2010-04-07
申请号：EP08786012.8
申请日：2008-07-09
IPC分类号： A61K31/05 , A61K31/122 , A61K31/353 , A61K31/7004 , A61K36/00 , A61K8/97 , A61K8/41 , A61K8/35 , A61K8/34 , A61P17/00 , A61P3/10 , A61Q19/08 , A23L1/29
CPC分类号： A61Q19/08 , A23L33/105 , A61K8/347 , A61K8/35 , A61K8/355 , A61K8/411 , A61K8/415 , A61K8/498 , A61K8/97 , A61K31/05 , A61K31/122 , A61K31/353 , A61K31/7004 , A61K36/15 , A61K36/45 , A61K36/48 , A61K36/52 , A61K36/70 , A61K36/708 , A61K36/73 , A61K36/734 , A61K36/76 , A61K36/77 , A61K36/889 , A61K36/90
摘要： The present invention relates to the use of an active substance that promotes the inhibition of AGE formation, for the preparation of a composition for preventing and/or combating the decrease in elastic and plastic properties of tissues, and in particular of the skin, for inhibiting AGE formation, or for preventing and/or combating protein glycation at the cutaneous level. The invention also relates to a method of screening for such active substances.
摘要翻译： 本发明涉及促进AGEs形成抑制活性物质的用途，用于制备组合物以预防和/或防止组织，特别是皮肤的弹性和塑性特性降低以抑制 AGEs的形成，或用于预防和/或防治皮肤中蛋白质的糖基化。 本发明还涉及筛选这种活性物质的方法。
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6.发明公开MC-1R, MC-2R, AND/OR µ OPIOID RECEPTORS STIMULATION 审中-公开MC-1R-，MC-2R-UND / ODER A OPIOID-REZEPTOR-STIMULATION
公开(公告)号：EP2157966A2
公开(公告)日：2010-03-03
申请号：EP08760698.4
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-1R, MC-2R, and the µ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
摘要翻译： 本发明涉及调节POMC基因（MC-1R，MC-2R和μ阿片受体）产物受体表达的活性物质，并且可能调节皮肤细胞中POMC的表达，特别是调节增殖 和表皮细胞的分化，以重新上皮，保持神经支配，刺激皮肤，或恢复正常的色素沉着，或抵抗衰老，或独立调节色素沉着或不是皮肤老化。 本发明还涉及筛选此类活性物质的方法。
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公开(公告)号：EP2170259A1
公开(公告)日：2010-04-07
申请号：EP08774551.9
申请日：2008-06-30
CPC分类号： A61K8/602 , A61K8/41 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K31/132 , A61K2800/51 , A61Q19/06
摘要： This invention relates to the use of a preparation comprising sulfated oligosaccharides which trap spermine and/or spermidine, as an active slimming ingredient in a cosmetic, pharmaceutical and/or nutraceutical composition. One aspect of the invention is to supply a cosmetic, pharmaceutical or nutriceutical composition with a slimming effect.
摘要翻译： 本发明涉及在化妆品，药物和/或营养组合物中作为活性减肥成分捕获精胺和/或亚精胺的硫酸化寡糖的制剂的用途。 本发明的一个方面是提供具有减肥效果的化妆品，药物或营养组合物。
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公开(公告)号：EP1853695A2
公开(公告)日：2007-11-14
申请号：EP06820794.3
申请日：2006-01-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , University Claude Bernard Lyon I
发明人： PERRIER, Eric , DAMOUR, Odile , ANDRE, Valerie
IPC分类号： C12M1/22
摘要： The invention relates to a cell culture device. This cell culture device (100), intended for receiving cells with their culture medium, is characterised in that it contains at least one cell-supporting layer of porous material, this layer being obtained by dehydration of an aqueous gel which is poured directly either into said well bottom (110-111), or into the bottom of a cradle or insert (150) of a size which is adapted for being insertable into the volume of the well. The invention enables a culture to be made which can be automated.
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公开(公告)号：EP2157966B1
公开(公告)日：2019-03-13
申请号：EP08760698.4
申请日：2008-06-06
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10.发明公开A METHOD FOR PRODUCING LANGERHANS CELLS AND/OR DERMAL/INTERSTITIAL DENTRITIC CELLS FROM CD14+ MONOCYTES 审中-公开用于生产朗格汉斯细胞和/或真皮/间质树突细胞CD14 +单核细胞
公开(公告)号：EP2064318A1
公开(公告)日：2009-06-03
申请号：EP07803152.3
申请日：2007-09-03
IPC分类号： C12N5/06
CPC分类号： C12N5/0639 , C12N5/0697 , C12N5/0698 , C12N2502/094 , C12N2502/097 , C12N2502/1121 , C12N2502/1157 , C12N2502/1323 , C12N2502/243
摘要： The present invention relates to a method for preparing Langerhans cells (LC), or dermal/interstitial dendritic cells (IDC) or LCs and IDCs from CD 14+ monocytes stemming from peripheral circulatory blood of a living being, and notably of a human being, comprising differentiation of CD 14+ monocytes into LCs, or into IDCs, or into LCs and IDCs by putting the CD 14+ monocytes in the presence of a cell environment comprising epithelial cells, such as keratinocytes, and/or mesenchymatous cells such as dermal fibroblasts. The present invention also relates to cell or tissue models comprising at least LCs and/or IDCs, and optionally macrophages and endothelial cells, able to be obtained according to this method, and to their uses.
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