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1.发明公开MC-1R, MC-2R, AND/OR µ OPIOID RECEPTORS STIMULATION 审中-公开MC-1R-，MC-2R-UND / ODER A OPIOID-REZEPTOR-STIMULATION
公开(公告)号：EP2157966A2
公开(公告)日：2010-03-03
申请号：EP08760698.4
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-1R, MC-2R, and the µ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
摘要翻译： 本发明涉及调节POMC基因（MC-1R，MC-2R和μ阿片受体）产物受体表达的活性物质，并且可能调节皮肤细胞中POMC的表达，特别是调节增殖 和表皮细胞的分化，以重新上皮，保持神经支配，刺激皮肤，或恢复正常的色素沉着，或抵抗衰老，或独立调节色素沉着或不是皮肤老化。 本发明还涉及筛选此类活性物质的方法。
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2.发明授权SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权SUBSTANZ ZUR WIEDERHERSTELLUNG DER NORMALEN CO-EXPRESSION UND INTEREKTION ZWISCHEN LOX-UND NRAGE-PROTEINEN
公开(公告)号：EP1948128B1
公开(公告)日：2017-03-15
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61Q19/08 , A61K36/77 , A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
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公开(公告)号：EP2245139A1
公开(公告)日：2010-11-03
申请号：EP09709947.7
申请日：2009-02-16
申请人： BASF Beauty Care Solutions France SAS , University Claude Bernard Lyon I , Centre National de la Recherche Scientifique (C.N.R.S) , Hospices Civils de Lyon
CPC分类号： C12N5/0068 , A61F2/142 , A61L27/3804 , A61L27/3839 , C12N5/0621 , C12N2533/54 , C12N2533/70 , C12N2533/72
摘要： The invention relates to a model of reconstructed cornea, which may be used especially in tissue engineering, to a biomaterial that may be used for preparing a reconstructed cornea, and also to a culture device allowing better reproducibility of the cultures of the model of reconstructed cornea.
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公开(公告)号：EP4262999A1
公开(公告)日：2023-10-25
申请号：EP21854671.1
申请日：2021-12-14
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公开(公告)号：EP2157966B1
公开(公告)日：2019-03-13
申请号：EP08760698.4
申请日：2008-06-06
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6.发明公开A METHOD FOR PRODUCING LANGERHANS CELLS AND/OR DERMAL/INTERSTITIAL DENTRITIC CELLS FROM CD14+ MONOCYTES 审中-公开用于生产朗格汉斯细胞和/或真皮/间质树突细胞CD14 +单核细胞
公开(公告)号：EP2064318A1
公开(公告)日：2009-06-03
申请号：EP07803152.3
申请日：2007-09-03
IPC分类号： C12N5/06
CPC分类号： C12N5/0639 , C12N5/0697 , C12N5/0698 , C12N2502/094 , C12N2502/097 , C12N2502/1121 , C12N2502/1157 , C12N2502/1323 , C12N2502/243
摘要： The present invention relates to a method for preparing Langerhans cells (LC), or dermal/interstitial dendritic cells (IDC) or LCs and IDCs from CD 14+ monocytes stemming from peripheral circulatory blood of a living being, and notably of a human being, comprising differentiation of CD 14+ monocytes into LCs, or into IDCs, or into LCs and IDCs by putting the CD 14+ monocytes in the presence of a cell environment comprising epithelial cells, such as keratinocytes, and/or mesenchymatous cells such as dermal fibroblasts. The present invention also relates to cell or tissue models comprising at least LCs and/or IDCs, and optionally macrophages and endothelial cells, able to be obtained according to this method, and to their uses.
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7.发明公开SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权物质恢复正常的共表达与互动之间LOX和NRAGE蛋白质
公开(公告)号：EP1948128A2
公开(公告)日：2008-07-30
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , University Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
摘要： The invention concerns a substance for restoring normal co-expression and interaction between LOX and NRAGE proteins. In particular, the invention concerns the use of an effective amount of at least one substance modulating the expression and/or the activity of LOX having the sequence ID N°1 and/or modulating the expression and/or the activity of NRAGE having the sequence ID N°2 for making a composition for modulating the interaction between the LOX and NRAGE proteins so as to regulate the balance between the phenomena of proliferating cells, of differentiation and apoptosis, in particular in cases where the interaction between LOX and NRAGE proteins is absent or altered. The invention enables in particular skin aging, lichen planus, a graft-versus-host reaction disease, an eczema, a psoriasis, and a cancer, in particular an epithelial cancer, particularly an epithelial skin cancer, of basocellular type, or of spinocellular type to prevented or treated.
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8.发明公开ACTIVE INGREDIENT THAT STIMULATES THE PROLIFERATION AND/OR ACTIVITY OF FIBROBLASTS 审中-公开增殖和/或活性刺激ACTIVE成纤维细胞
公开(公告)号：EP2273973A1
公开(公告)日：2011-01-19
申请号：EP08774074.2
申请日：2008-06-12
发明人： RIVAL, Delphine , ANDRE, Valérie , LAMY, Louis
摘要： The invention relates to a novel active ingredient that stimulates the proliferation and/or the activity of fibroblasts and also to its applications in the cosmetic or pharmaceutical, in particular dermatological, field. In particular, the active ingredient according to the invention comprises a combination of at least one Hibiscus Abelmoschus extract and a soy extract containing at least peptides.
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9.发明公开SUBSTANCES RAISING THE ACTIVATION THRESHOLD OF IMMUNE CELL 审中-公开物质卫生间AKTI AKTI AKTI EN LE LE LE EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP2252257A2
公开(公告)日：2010-11-24
申请号：EP09718916.1
申请日：2009-03-16
CPC分类号： A61K36/28 , A61K8/97 , A61K36/47 , A61K2800/75 , A61Q19/005
摘要： The present invention relates to the use of active substances that increase the activation threshold of immune cells as an active principle for the preparation of a cosmetic or pharmaceutical composition, especially a dermatological composition. The invention also relates to a method for screening such active substances.
摘要翻译： 本发明涉及增加免疫细胞的活化阈值的活性物质的用途，作为制备化妆品或药物组合物，特别是皮肤病学组合物的活性成分。 本发明还涉及筛选这种活性物质的方法。
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公开(公告)号：EP2157978A2
公开(公告)日：2010-03-03
申请号：EP08760699.2
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
IPC分类号： A61K36/14 , A61K8/97 , A61Q19/08 , A61P17/00 , A61K31/437
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the μ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
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