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1.发明授权Verfahren zur Herstellung optisch aktiver Alkohole unter Verwendung einer Dehydrogenase aus Azoarcus sp. EbN1 有权一种用于生产使用来自固氮弧菌属脱氢酶的光学活性醇的方法。 EbN1
公开(公告)号：EP2171074B1
公开(公告)日：2011-11-30
申请号：EP08774090.8
申请日：2008-06-16
申请人： BASF SE , Albert-Ludwigs-Universität Freiburg , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： BREUER, Michael , RABUS, Ralf , HEIDER, Johann
IPC分类号： C12P7/02
CPC分类号： C12P7/02
摘要： A method for producing optically active alcohols of formula (Ia) or (Ib), wherein R1, R2 are alkyl, alkenyl, aryl, or alkylaryl groups, which in turn can be mono-substituted or poly-substituted with alkyl, halogen, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 or NR2R3R4+X, wherein R2, R3 and R4 independently of each other are H or a low-alkyl or low-alkoxy radical, and X- is a counterion, with the stipulation that R1 is not identical to R2, by reduction of the corresponding ketone, the reduction being performed with a dehydrogenase having the polypeptide sequence SEQ ID NO:2 or NO:4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified relative to SEQ ID NO:2 or NO:4 by deletion, insertion, substitution, or a combination thereof.
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2.发明公开VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER ALKOHOLE UNTER VERWENDUNG EINER AZOARCUS SP. EBN1 DEHYDROGENASE 有权一种用于生产使用来自固氮弧菌属脱氢酶的光学活性醇的方法。 EbN1
公开(公告)号：EP2171074A1
公开(公告)日：2010-04-07
申请号：EP08774090.8
申请日：2008-06-16
申请人： BASF SE , Albert-Ludwigs-Universitaet Freiburg , Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.
发明人： BREUER, Michael , RABUS, Ralf , HEIDER, Johann
IPC分类号： C12P7/02
CPC分类号： C12P7/02
摘要： A method for producing optically active alcohols of formula (Ia) or (Ib), wherein R1, R2 are alkyl, alkenyl, aryl, or alkylaryl groups, which in turn can be mono-substituted or poly-substituted with alkyl, halogen, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 or NR2R3R4+X, wherein R2, R3 and R4 independently of each other are H or a low-alkyl or low-alkoxy radical, and X- is a counterion, with the stipulation that R1 is not identical to R2, by reduction of the corresponding ketone, the reduction being performed with a dehydrogenase having the polypeptide sequence SEQ ID NO:2 or NO:4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified relative to SEQ ID NO:2 or NO:4 by deletion, insertion, substitution, or a combination thereof.
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公开(公告)号：EP4409014A1
公开(公告)日：2024-08-07
申请号：EP22800120.2
申请日：2022-09-29
CPC分类号： C12Y602/01004 , C12Y602/01009 , C12Y602/01001 , C12Y208/03 , C12Y102/01076 , C12Y101/01001 , C12R2001/1920210501 , C12P17/04 , C12N15/70 , C12N15/52
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公开(公告)号：EP4263847A1
公开(公告)日：2023-10-25
申请号：EP21836205.1
申请日：2021-12-20
申请人： BASF SE
IPC分类号： C12P13/06 , C07C227/18 , C07C227/36 , C07C229/16
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6.发明公开
公开(公告)号：EP3470515A3
公开(公告)日：2019-05-29
申请号：EP18203725.9
申请日：2011-11-17
申请人： BASF SE
发明人： BREUER, Michael , HAUER, Bernhard , JENDROSSEK, Dieter , SIEDENBURG, Gabriele , PLEISS, Jürgen , SIRIM, Demet , RACOLTA, Silvia
摘要： Die vorliegende Erfindung betrifft neuartige Mutanten mit Cyclase-Aktivität und deren Anwendung in einem Verfahren zur biokatalytischen Cyclisierung von Terpenen, wie insbesondere zur Herstellung von Isopulegol durch Cyclisierung von Citronellal; ein Verfahren zur Herstellung von Menthol sowie Verfahren zur biokatalytischen Umsetzung weiterer Verbindungen mit Terpenähnlichen Strukturmotiven.
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公开(公告)号：EP3201184B1
公开(公告)日：2019-01-02
申请号：EP15770541.9
申请日：2015-09-28
申请人： BASF SE
发明人： BREUER, Michael , PELZER, Ralf
IPC分类号： C07D311/92 , C12P17/06
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公开(公告)号：EP3027759A1
公开(公告)日：2016-06-08
申请号：EP14741872.7
申请日：2014-07-21
申请人： BASF SE
发明人： BREUER, Michael , BREITSCHEIDEL, Boris , WAGNER, Hans-Günter , KRATZ, Detlef , HAUER, Bernhard , SCHEPS, Daniel , NEBEL, Bernd
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12Y114/15003 , C12Y118/01001 , Y02E50/10
摘要： A process for preparing 1-butanol from butane by incubating a host organism having a functional P153 enzyme under elevated butane pressure in the presence of oxygen.
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9.发明公开VERFAHREN ZUR HERSTELLUNG N-HETEROZYKLISCHER OPTISCH AKTIVER ALKOHOLE 审中-公开METHOD FOR PRODUCING N-杂环的光学活性醇
公开(公告)号：EP2643467A1
公开(公告)日：2013-10-02
申请号：EP11784705.3
申请日：2011-11-22
申请人： BASF SE
发明人： SCHNEIDER, Nina , BONNEKESSEL, Melanie , BREUER, Michael , DÄUWEL, Jürgen , DITRICH, Klaus , KARL, Ulrich , STÄB, Tobias
CPC分类号： C12N9/0006 , C07D211/22 , C07D213/30 , C12P7/22 , C12P17/10 , C12P17/12 , C12P41/002
摘要： Method for producing N-heterocyclic optically active alcohols of the formula (I), where R
1 represents alkyl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR
3 , OH, OR
3 , NO
2 , CN, CO, COOR
3 , NR
3 R
4 or NR
3 R
3 R
5+ X
- , where R
3 , R
4 and R
5 independently of one another are H or a low-alkyl or low-alkoxy radical and X
- is a counterion, R
2 is N-containing heteroaryl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR
3 , OH, OR
3 , NO
2 , CN, CO, COOR
3 , NR
3 R
4 or NR
3 R
3 R
5+ X
- , where R
3 , R
4 and R
5 independently of one another are H or a low-alkyl or low-alkoxy radical and X
- is a counterion, by reduction of the corresponding ketone, wherein the reduction is carried out using a dehydrogenase having the polypeptide sequence SEQ ID NO: 2 or NO: 4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified in comparison with SEQ ID NO: 2 or NO: 4 by deletion, insertion, substitution or a combination thereof.-
10.发明授权VERFAHREN ZUR HERSTELLUNG VON (4S)-3,4-DIHYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-2-ENON UND DERIVATEN DAVON UNTER VERWENDUNG DER AZOARCUS PHENYLETHANOL DEHYDROGENASE 有权用于生产（4S）-3,4-二羟基-2,6,6-三甲基环己-2- ENON及其衍生物的使用固氮弧菌苯乙醇脱氢酶
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