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公开(公告)号：EP4409014A1
公开(公告)日：2024-08-07
申请号：EP22800120.2
申请日：2022-09-29
CPC分类号： C12Y602/01004 , C12Y602/01009 , C12Y602/01001 , C12Y208/03 , C12Y102/01076 , C12Y101/01001 , C12R2001/1920210501 , C12P17/04 , C12N15/70 , C12N15/52
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公开(公告)号：EP3102675B1
公开(公告)日：2019-03-27
申请号：EP15709418.6
申请日：2015-02-02
申请人： BASF SE
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公开(公告)号：EP3436574A1
公开(公告)日：2019-02-06
申请号：EP17712983.0
申请日：2017-03-22
申请人： BASF SE
发明人： SAUM, Stephan , KIM, Woncheol , ZELDER, Oskar , JAITZIG, Jennifer , GUO, Zheyuan
IPC分类号： C12N9/10 , C12P7/62 , C08F220/18
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4.发明公开IMPROVED MICROORGANISMS FOR SUCCINIC ACID PRODUCTION 审中-公开VERBESSERTE MIKROORGANISMENFÜRDIE PRODUKTION VONBERNSTEINSÄURE
公开(公告)号：EP3102675A1
公开(公告)日：2016-12-14
申请号：EP15709418.6
申请日：2015-02-02
申请人： BASF SE
发明人： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHRÖDER, Hartwig , DANTAS COSTA, Esther , ZELDER, Oskar , VON ABENDROTH, Gregory , WITTMANN, Christoph , STELLMACHER, René , BECKER, Judith , LANGE, Anna , LYONS, Benjamin J. , LYONS, Thomas J. , DE CRECY, Eudes , HUGHES, Ewa
CPC分类号： C12N9/1205 , C12N15/52 , C12P7/46 , C12Y207/0104
摘要： The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
摘要翻译： 本发明涉及与其野生型相比具有由pykA基因编码的酶的活性降低的修饰微生物。 本发明还涉及有机化合物的制造方法和改性微生物的使用。
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公开(公告)号：EP2013353B1
公开(公告)日：2016-06-22
申请号：EP07727257.3
申请日：2007-03-23
申请人： BASF SE
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
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公开(公告)号：EP2235194B1
公开(公告)日：2011-07-20
申请号：EP09704118.0
申请日：2009-01-23
申请人： BASF SE
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C07C209/84 , C07C211/09
摘要： The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermative production of DAP using said isolating method and to a method for producing DAP-containing polymers using the isolated or fermatively produced DAPs according to said methods.
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7.发明公开PRODUCTION PROCESS FOR FINE CHEMICALS USING MICROORGANISMS WITH REDUCED ISOCITRATE DEHYDROGENASE ACTIVITY 审中-公开生产中使用微生物具有降低的异柠檬酸脱氢酶活性精细化工
公开(公告)号：EP2283142A1
公开(公告)日：2011-02-16
申请号：EP09738158.6
申请日：2009-04-28
申请人： BASF SE
发明人： HEROLD, Andrea , SCHRÖDER, Hartwig , JEONG, Weol Kyu , KLOPPROGGE, Corinna , ZELDER, Oskar , HAEFNER, Stefan , RICHTER, Ulrike , BECKER, Judith , WITTMANN, Christoph
CPC分类号： C12P13/001 , C12N9/0006 , C12P13/02 , C12P13/08 , C12P13/12 , C12P13/20
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.
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公开(公告)号：EP2013353A1
公开(公告)日：2009-01-14
申请号：EP07727257.3
申请日：2007-03-23
申请人： BASF SE
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
摘要： Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahy- drodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl- diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
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公开(公告)号：EP1907559A1
公开(公告)日：2008-04-09
申请号：EP06800212.0
申请日：2006-07-18
申请人： BASF SE
发明人： ZELDER, Oskar , HAEFNER, Stefan , KLOPPROGGE, Corinna , SCHRODER, Hartwig , HEROLD, Andrea , PATTERSON, Thomas, A. , HERMANN, Theron , YOCUM, Rogers, R. , WILLIAMS, Mark, K. , PERO, Janice, G.
IPC分类号： C12P13/12
摘要： This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
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公开(公告)号：EP3502241A1
公开(公告)日：2019-06-26
申请号：EP17209645.5
申请日：2017-12-21
申请人： BASF SE
发明人： HOFF, Birgit , BOEHMER, Nico , HAEFNER, Stefan , SCHROEDER, Hartwig , ZELDER, Oskar , WITTMANN, Christoph , SCHROER, Anna Christine
摘要： The present invention relates to a process of producing an organic compound, the process comprising
I) cultivating a genetically modified microorganism in a culture medium comprising at least one assimilable carbon source to allow the genetically modified microorganism to produce the organic compound,
II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises
A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the udhA -gene, compared to the original microorganism that has not been genetically modified,
and wherein the original microorganism belongs to the family Pasteurellaceae.
The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from at least one assimilable carbon source.
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