公开(公告)号：EP1545641A1

公开(公告)日：2005-06-29

申请号：EP03752202.6

申请日：2003-09-10

申请人： BAUSCH & LOMB INCORPORATED

发明人： BORAZJANI, Roya ,  AMMON, Daniel, M., Jr. ,  SALAMONE, Joseph, C. ,  HU, Zhenze ,  JANI, Dharmendra, M.

IPC分类号： A61L27/34 ,  A61L12/08

CPC分类号： C11D1/008 ,  A61L12/08 ,  A61L12/141 ,  A61L12/142 ,  A61L12/145 ,  A61L27/34 ,  C11D1/44 ,  C11D1/722 ,  C11D3/0078 ,  C11D3/227 ,  C11D3/323 ,  C11D3/3707 ,  C11D3/48 ,  C11D11/0041 ,  C08L71/02

摘要： Compositions for inhibiting attachment of microorganisms to the surface of biomaterials include a polyether, such as a poloxamer. The compositions are especially useful for treating contact lenses to prevent bacterial attachment to the lens.

公开(公告)号：EP2032102B1

公开(公告)日：2010-07-28

申请号：EP07798742.8

申请日：2007-06-19

申请人： Bausch & Lomb Incorporated

发明人： KNOX, Wayne, H. ,  DING, Li ,  KUNZLER, Jay, Friedrich ,  JANI, Dharmendra, M. ,  PINTO, Candido, D.

IPC分类号： A61F9/008 ,  A61F9/00

CPC分类号： A61F2/1624 ,  A61F2/16 ,  A61F2/1627 ,  A61F2/1635 ,  A61F9/008 ,  A61F9/00834 ,  A61F2009/00842 ,  A61F2009/00897 ,  G02C7/04 ,  G02C2202/14

摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, which exhibit little or no scattering loss. The method can he used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, which exhibit little or no scattering loss and are characterized by a positive change in refractive index.

公开(公告)号：EP1732620A1

公开(公告)日：2006-12-20

申请号：EP05726035.8

申请日：2005-03-22

申请人： BAUSCH & LOMB INCORPORATED

发明人： BUCOLO, Claudio ,  CRO, Melina, G. ,  MALTESE, Adriana, L. A. ,  JANI, Dharmendra, M.

IPC分类号： A61L31/04

CPC分类号： A61L31/042 ,  A61L31/10 ,  A61L31/143 ,  A61L2430/16

摘要： The present invention is directed to a viscoelastic composition comprising an aqueous solution having a minimum of about 0.01%w/v and a maximum of about 20%w/v of a viscoelastic polymer based upon the total volume of the viscoelastic composition. Typically, the viscoelastic composition further contains tris[hydroxymethyl]aminomethane and a polyol (for example sorbitol). The present invention also includes methods of use of the new viscoelastic composition and a packaging device.

公开(公告)号：EP2713950A1

公开(公告)日：2014-04-09

申请号：EP12724845.8

申请日：2012-05-29

申请人： Bausch & Lomb Incorporated ,  University of Rochester

发明人： SMITH, Thomas ,  KNOX, Wayne, H. ,  JANI, Dharmendra, M. ,  DING, Li

IPC分类号： A61F2/16 ,  A61F9/008 ,  A61L27/52

CPC分类号： G02B3/0087 ,  A61F2/1618 ,  A61F2/1627 ,  A61F9/00834 ,  A61L27/16 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/18 ,  A61L2430/16 ,  G02B2003/0093 ,  G02C2202/12 ,  G02C2202/14 ,  C08L33/10

摘要： A method for modifying the refractive index of an optical polymeric material. The method comprises continuously irradiating predetermined regions of an optical, polymeric material with femtosecond laser pulses to form a gradient index refractive structure within the material. An optical device includes an optical, polymeric lens material having an anterior surface and posterior surface and an optical axis intersecting the surfaces and at least one laser-modified, GRIN layer disposed between the anterior surface and the posterior surface and arranged along a first axis 45° to 90° to the optical axis, and further characterized by a variation in index of refraction across at least one of at least a portion of the adjacent segments and along each segment.

公开(公告)号：EP1811958A2

公开(公告)日：2007-08-01

申请号：EP05810156.9

申请日：2005-10-11

申请人： BAUSCH & LOMB INCORPORATED

发明人： KUNZLER, Jay, F. ,  JANI, Dharmendra, M. ,  SALAMONE, Joseph, C.

IPC分类号： A61K9/00

CPC分类号： A61K9/0051 ,  A61F9/0017

摘要： A method for making an ocular drug delivery device involves subjecting the device to a supercritical fluid to remove contaminants from the device. The supercritical fluid includes supercritical carbon dioxide. The contaminants include unreacted monomers or oligomers present in the polymeric material used to form the device.

公开(公告)号：EP2326285A2

公开(公告)日：2011-06-01

申请号：EP09751282.6

申请日：2009-05-18

申请人： Bausch & Lomb Incorporated ,  Rochester Institute of Technology ,  University Of Rochester

发明人： SMITH, Thomas ,  KNOX, Wayne, H. ,  DING, Li ,  JANI, Dharmendra, M. ,  LINHARDT, Jrffrey, G.

IPC分类号： A61F2/16

CPC分类号： A61F9/00804 ,  A61F2/1451 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  B29D11/00009 ,  G02C2202/14

摘要： An intraocular lens comprising an optical, polymeric material with predetermine regions that have been irradiated with light from a laser to form refractive structures. The refractive structures are characterized by a change in refractive index within the irradiated regions of the lens with little or no scattering loss. To facilitate the formation of the refractive structures the optical, polymeric material is prepared from at least one monomer having a photofunctional group, the monomer having a two-photon cross- section of at least 10 GM. The invention is also directed to a method for modifying the refractive index of an intraocular lens prior to the surgical insertion of the lens in a human eye. The described irradiation process is used in a manufacturing environment to create refractive structures in the intraocular lens. The method includes irradiating a solvated intraocular lens at predetermined regions with light from a laser to form refractive structures.

公开(公告)号：EP1732620B1

公开(公告)日：2008-07-23

申请号：EP05726035.8

申请日：2005-03-22

申请人： BAUSCH & LOMB INCORPORATED

发明人： BUCOLO, Claudio ,  CRO, Melina, G. ,  MALTESE, Adriana, L. A. ,  JANI, Dharmendra, M.

IPC分类号： A61L31/04

CPC分类号： A61L31/042 ,  A61L31/10 ,  A61L31/143 ,  A61L2430/16

摘要： The present invention is directed to a viscoelastic composition comprising an aqueous solution having a minimum of about 0.01%w/v and a maximum of about 20%w/v of a viscoelastic polymer based upon the total volume of the viscoelastic composition. Typically, the viscoelastic composition further contains tris[hydroxymethyl]aminomethane and a polyol (for example sorbitol). The present invention also includes methods of use of the new viscoelastic composition and a packaging device.

公开(公告)号：EP2326285B1

公开(公告)日：2012-02-15

申请号：EP09751282.6

申请日：2009-05-18

申请人： Bausch & Lomb Incorporated ,  Rochester Institute of Technology ,  University Of Rochester

发明人： SMITH, Thomas ,  KNOX, Wayne, H. ,  DING, Li ,  JANI, Dharmendra, M. ,  LINHARDT, Jeffrey, G.

IPC分类号： A61F2/16

CPC分类号： A61F9/00804 ,  A61F2/1451 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  B29D11/00009 ,  G02C2202/14

摘要： An intraocular lens comprising an optical, polymeric material with predetermine regions that have been irradiated with light from a laser to form refractive structures. The refractive structures are characterized by a change in refractive index within the irradiated regions of the lens with little or no scattering loss. To facilitate the formation of the refractive structures the optical, polymeric material is prepared from at least one monomer having a photofunctional group, the monomer having a two-photon cross- section of at least 10 GM. The invention is also directed to a method for modifying the refractive index of an intraocular lens prior to the surgical insertion of the lens in a human eye. The described irradiation process is used in a manufacturing environment to create refractive structures in the intraocular lens. The method includes irradiating a solvated intraocular lens at predetermined regions with light from a laser to form refractive structures.

公开(公告)号：EP2032102A2

公开(公告)日：2009-03-11

申请号：EP07798742.8

申请日：2007-06-19

申请人： Bausch & Lomb Incorporated

发明人： KNOX, Wayne, H. ,  DING, Li ,  KUNZLER, Jay, Friedrich ,  JANI, Dharmendra, M. ,  PINTO, Candido, D.

IPC分类号： A61F9/008 ,  A61F9/00

CPC分类号： A61F2/1624 ,  A61F2/16 ,  A61F2/1627 ,  A61F2/1635 ,  A61F9/008 ,  A61F9/00834 ,  A61F2009/00842 ,  A61F2009/00897 ,  G02C7/04 ,  G02C2202/14

摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, which exhibit little or no scattering loss. The method can he used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, which exhibit little or no scattering loss and are characterized by a positive change in refractive index.

摘要翻译： 用于改变光学聚合材料的折射率的方法。 该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。 照射导致折射光学结构的形成，其表现出很少或没有散射损失。 该方法可以用于修改在人眼中手术植入人工晶状体后的眼内透镜的折射率。 本发明还涉及一种包括折射光学结构的光学装置，其表现出很少或没有散射损失，并且其特征在于折射率的正变化。

公开(公告)号：EP1877856A1

公开(公告)日：2008-01-16

申请号：EP06758957.2

申请日：2006-05-02

申请人： BAUSCH & LOMB INCORPORATED

发明人： JANI, Dharmendra, M. ,  KUNZLER, Jay, F. ,  SALAMONE, Joseph, C.

IPC分类号： G02C7/10 ,  G02B5/23 ,  C07D311/92

CPC分类号： G02B5/23 ,  A61L27/50 ,  A61L2430/16 ,  G02B1/043 ,  G02C7/102 ,  G03C1/73

摘要： Polymeric compositions have photochromic and blue-light filtering ability and are useful in the manufacture of ophthalmic medical devices. The polymeric compositions comprise a photochromic material incorporated into polymeric host materials and are activatable by blue light having a first wavelength range to become photochromic, and are thereby capable of absorbing blue light in a second wavelength range. Methods of making the compositions comprise incorporating a photochromic material having a reactive functional group into a polymeric host material.