公开(公告)号：EP2446899A4

公开(公告)日：2013-08-14

申请号：EP10792358

申请日：2010-06-25

申请人： BIOLEADERS CORP ,  UNIV KOOKMIN IND ACAD COOP FOUND ,  KOREA RES INST OF BIOSCIENCE ,  INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NAT UNIVERSITY ,  NAT UNIV CHUNGBUK IND ACAD

发明人： SUNG MOON-HEE ,  POO HARYOUNG ,  KIM CHUL JOONG ,  CHOI YOUNG-KI ,  LIM YONG TAIK ,  JEONG DONG JIN ,  SHIM SANG-MU

IPC分类号： A61K39/39 ,  A61K39/145 ,  A61P31/16 ,  A61P35/00

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/543 ,  A61K2039/55583 ,  C12N2760/16134

摘要： The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.

公开(公告)号：EP1629104A4

公开(公告)日：2006-11-02

申请号：EP04736153

申请日：2004-06-04

申请人： BIOLEADERS CORP ,  M D LAB ,  BIOLEADERS JAPAN CORP ,  KOREA RES INST OF BIOSCIENCE

发明人： SUNG MOON HEE ,  KIM CHUL JOONG ,  JUNG CHANG MIN ,  HONG SEUNG PYO ,  LEE JONG SU ,  CHOI JAE CHUL ,  KIM KWANG ,  SHUNICHI KURODA ,  POO HA RYOUNG

IPC分类号： C12N15/86 ,  A61K39/00 ,  C07K14/025 ,  C07K14/165 ,  C12N9/00 ,  C12N15/74

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/523 ,  C07K2319/00 ,  C12N9/93 ,  C12N15/74 ,  C12N2710/20022 ,  C12N2770/20022

摘要： The present invention relates to a surface expression vector of SARS coronavirus antigen containing a gene encoding an antigen of SARS inducing coronavirus and any one or two or more of genes pgsB, pgsC and pgsA encoding poly-gamma-glutamic acid synthase complex, a microorganism transformed by the surface expression vector, and a SARS vaccine comprising the microorganism. According to the present invention, it is possible to economically produce a vaccine for prevention and treatment of SARS using a recombinant strain expressing an SARS coronavirus antigen on their surface.

公开(公告)号：EP2187897A4

公开(公告)日：2010-10-20

申请号：EP07808211

申请日：2007-09-13

申请人： BIOLEADERS CORP ,  KOREA RES INST OF BIOSCIENCE

发明人： SUNG MOON-HEE ,  KIM CHUL JOONG ,  POO HARYOUNG ,  CHOI YOUNG-KI ,  LEE IL HAN ,  YOO DAI-WON

IPC分类号： A61K31/785 ,  A61K47/30 ,  A61P31/12

CPC分类号： A61K31/785 ,  A61K38/164

公开(公告)号：EP1850870A4

公开(公告)日：2009-01-28

申请号：EP05819088

申请日：2005-12-06

申请人： BIOLEADERS CORP ,  M D LAB CO LTD ,  KOREA RES INST OF BIOSCIENCE

发明人： SUNG MOON HEE ,  KIM CHUL JOONG ,  POO HA RYOUNG ,  HONG SEUNG PYO ,  LEE JONG SOO ,  KIM JI YOUN

IPC分类号： A61K39/39 ,  A61K47/30

CPC分类号： A61K39/39 ,  A61K2039/55516