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1.发明授权NEW PYRIDONE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 有权与MCH拮抗作用及药物的新吡啶酮衍生物，这些化合物
公开(公告)号：EP2069327B1
公开(公告)日：2013-10-16
申请号：EP07819958.5
申请日：2007-08-20
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , ROTH, Gerald Juergen , KLEY, Joerg , RUDOLF, Klaus , HECKEL, Armin , SCHINDLER, Marcus , LOTZ, Ralf
IPC分类号： C07D401/10 , C07D403/10 , C07D403/14 , C07D405/12 , C07D409/14 , C07D417/06 , A61K31/435 , A61K31/495
CPC分类号： C07D401/14 , C07D213/63 , C07D213/69 , C07D213/74 , C07D237/14 , C07D237/16 , C07D239/52 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/14 , C07D409/14 , C07D417/12 , C07D451/06 , C07D471/04 , C07D513/04
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公开(公告)号：EP1828123A1
公开(公告)日：2007-09-05
申请号：EP05817469.9
申请日：2005-12-15
发明人： MCCONNELL, Darryl , WEYER-CZERNILOFSKY, Ulrike , IMPAGNATIELLO, Maria , STEURER, Steffen , BRUECKNER, Ralph , KRIST, Bernd , BETZEMEIER, Bodo , HILBERG, Frank , HECKEL, Armin , ROTH, Gerald Juergen , KLEY, Joerg , LEHMANN-LINTZ, Thorsten
IPC分类号： C07D209/34 , C07D405/06 , C07D403/12 , C07D413/04 , C07D401/10 , C07D405/10 , C07D403/04 , C07D401/14 , C07D409/04 , C07D401/04 , A61K31/4523 , A61P35/00
CPC分类号： C07D409/04 , C07D209/34 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/10 , C07D413/04
摘要： The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
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3.发明公开NEUE ALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的含烷基5 ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727799A1
公开(公告)日：2006-12-06
申请号：EP05715811.5
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D209/34 , C07D401/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D401/06 , A61K31/501 , A61P25/28
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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4.发明授权NEUE ALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的含烷基5 ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727799B1
公开(公告)日：2009-01-07
申请号：EP05715811.5
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D209/34 , C07D401/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D401/06 , A61K31/501 , A61P25/28
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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5.发明授权NEUE ARYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEY ARYL-HALTIGE 5-ACYLINDOLINONE，DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL
公开(公告)号：EP1727798B1
公开(公告)日：2008-10-29
申请号：EP05715810.7
申请日：2005-03-05
IPC分类号： C07D209/34 , A61K31/404
CPC分类号： C07D209/34 , C07D403/12 , C07D405/06
摘要： The invention relates to aryl-containing 5-acylindolinones of general formula (I) in which R1 to R3 are defined as in Claims 1 to 7, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, all of which having valuable pharmacological properties, particularly an inhibitory effect upon protein kinases, particularly an inhibitory effect upon the activity of glycogen synthase kinase (GSK-3).
摘要翻译： 本发明涉及通式为其中R 1至R 3的芳基的5-取代吲哚酮，其互变异构体，对映异构体，非对映异构体，其混合物 其具有有价值的药理学特性，特别是对蛋白激酶的抑制作用，特别是对糖原合酶激酶（GSK-3）的活性的抑制作用。
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6.发明公开(HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 审中-公开（杂）与MCH拮抗作用和芳基化合物药物同这些链接
公开(公告)号：EP1943231A1
公开(公告)日：2008-07-16
申请号：EP06807530.8
申请日：2006-10-25
发明人： ROTH, Gerald Juergen , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , STENKAMP, Dirk , LUSTENBERGER, Philipp , KLEY, Joerg , RUDOLF, Klaus , HECKEL, Armin , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf R. H.
IPC分类号： C07D237/08 , A61K31/501 , A61P3/04
CPC分类号： C07D237/08
摘要： The present invention relates to (hetero)aryl compounds of general formula (I) wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to 10 the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
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7.发明公开NEUE CYCLOALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW环烷基含有5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727812A1
公开(公告)日：2006-12-06
申请号：EP05715812.3
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D401/12 , C07D209/34 , C07D451/14 , C07D403/12 , C07D409/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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8.发明公开NEW PYRIDAZINE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 审中-公开与MCH拮抗作用及药物的新哒嗪，该链接包
公开(公告)号：EP2102171A1
公开(公告)日：2009-09-23
申请号：EP07848015.9
申请日：2007-12-10
发明人： LEHMANN-LINTZ, Thorsten , STENKAMP, Dirk , ROTH, Gerald Juergen , MUELLER, Stephan Georg , KLEY, Joerg , HECKEL, Armin , RUDOLF, Klaus , SCHINDLER, Marcus , LOTZ, Ralf , TIELMANN, Patrick
IPC分类号： C07D237/14 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/10 , C07D471/04 , A61K31/50 , A61K31/501 , A61P3/04
CPC分类号： C07D237/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/10 , C07D471/04
摘要： The present invention relates to compounds of general formula I wherein the groups and radicals B, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
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9.发明授权NEUE CYCLOALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW环烷基含有5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727812B1
公开(公告)日：2008-12-31
申请号：EP05715812.3
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D401/12 , C07D209/34 , C07D451/14 , C07D403/12 , C07D409/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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10.发明公开NEUE ARYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新芳基含5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727798A1
公开(公告)日：2006-12-06
申请号：EP05715810.7
申请日：2005-03-05
IPC分类号： C07D209/34 , A61K31/404
CPC分类号： C07D209/34 , C07D403/12 , C07D405/06
摘要： The invention relates to aryl-containing 5-acylindolinones of general formula (I) in which R1 to R3 are defined as in Claims 1 to 7, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, all of which having valuable pharmacological properties, particularly an inhibitory effect upon protein kinases, particularly an inhibitory effect upon the activity of glycogen synthase kinase (GSK-3).
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