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公开(公告)号：EP3383860A1
公开(公告)日：2018-10-10
申请号：EP16813199.3
申请日：2016-12-02
IPC分类号： C07D401/14 , C07D401/10 , C07D403/06 , C07D403/10 , C07D239/54 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/14 , A61K31/513 , A61P9/10 , A61P9/12 , A61P9/04
CPC分类号： C07D403/06 , C07D239/54 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/14
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：EP2785693B1
公开(公告)日：2016-05-18
申请号：EP12821212.3
申请日：2012-11-30
发明人： TURDI, Huji , HANGELAND, Jon J. , LAWRENCE, R. Michael , CHENG, Dong , AHMAD, Saleem , MENG, Wei , BRIGANCE, Robert Paul , DEVASTHALE, Pratik , ZHAO, Guohua
IPC分类号： C07D211/86 , C07D211/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/14 , C07F9/40 , A61K31/4418 , A61K31/4427 , A61P3/00
CPC分类号： A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/598
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公开(公告)号：EP1831180B1
公开(公告)日：2015-07-29
申请号：EP05855333.0
申请日：2005-12-23
IPC分类号： C07D239/26 , A61P3/10
CPC分类号： C07D239/26 , C07D239/42
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公开(公告)号：EP2785693A1
公开(公告)日：2014-10-08
申请号：EP12821212.3
申请日：2012-11-30
发明人： TURDI, Huji , HANGELAND, Jon J. , LAWRENCE, R. Michael , CHENG, Dong , AHMAD, Saleem , MENG, Wei , BRIGANCE, Robert Paul , DEVASTHALE, Pratik , ZHAO, Guohua
IPC分类号： C07D211/86 , C07D211/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/14 , C07F9/40 , A61K31/4418 , A61K31/4427 , A61P3/00
CPC分类号： A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D211/86 , C07D211/90 , C07D221/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/4006 , C07F9/5352 , C07F9/598
摘要： The present invention provides compounds of Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
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公开(公告)号：EP2558461A1
公开(公告)日：2013-02-20
申请号：EP11716736.1
申请日：2011-04-14
发明人： MENG, Wei , CHENG, Peter T. W.
IPC分类号： C07D403/12 , C07D417/12 , A61P3/10 , A61P3/04
CPC分类号： C07D403/12 , C07D417/12
摘要： Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , Y and X are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related disease employing the above compounds is also provided.-
公开(公告)号：EP1506211A1
公开(公告)日：2005-02-16
申请号：EP03736643.2
申请日：2003-05-15
CPC分类号： C07C43/225 , A61K31/70 , A61K31/7034 , A61K45/06 , C07C45/46 , C07C49/84 , C07H7/04 , C07H15/203 , A61K2300/00
摘要： An SGLT2 inhibiting compound is provided having the formula[Chemical structure] A method is also provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of the above compound alone or in combination with another antidiabetic agent or other therapeutic agent.
摘要翻译： 提供具有下式的SGLT2抑制性化合物：[化学结构]还提供了一种方法，用于单独或与另一种抗糖尿病剂或其他治疗剂组合使用SGLT2抑制量的上述化合物来治疗糖尿病和相关疾病。
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公开(公告)号：EP3468956A1
公开(公告)日：2019-04-17
申请号：EP17732693.1
申请日：2017-06-14
发明人： TORA, George, O. , FINLAY, Heather , JIANG, Wen , MENG, Wei , ZHANG, Xiaojun
IPC分类号： C07D239/60 , C07D401/12 , A61K31/513 , A61K31/506 , A61P9/00 , A61P9/04 , A61P9/10 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
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公开(公告)号：EP3468952A1
公开(公告)日：2019-04-17
申请号：EP17731794.8
申请日：2017-06-14
发明人： JIANG, Ji , FINLAY, Heather , KIM, Soong-Hoon , MENG, Wei , TORA, George O.
IPC分类号： C07D213/71 , C07D213/74 , C07D213/89 , C07D401/12 , C07D471/04 , A61K31/444 , A61P9/10
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9.发明公开DIHYDROPYRIDINONE MGAT2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS 审中-公开DIHYDROPYRIDINON-MGAT2-INHIBITOREN ZUR VERWENDUNG BEI DER BEHANDLUNG VON STOFFWECHSELERKRANKUNGEN
公开(公告)号：EP3114121A1
公开(公告)日：2017-01-11
申请号：EP15710687.3
申请日：2015-03-05
发明人： MENG, Wei , ZHAO, Guohua
IPC分类号： C07D401/14 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , A61K31/4418 , A61K31/444 , A61K31/506 , A61P3/00 , A61P9/00
CPC分类号： C07D409/14 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D409/04 , C07D417/14
摘要： or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
摘要翻译： 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的单酰基甘油酰基转移酶2型（MGAT2）抑制剂。
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10.发明公开PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS 有权膦酸盐和PHOSPHINATVERBINDUNGEN ALS葡萄糖激酶激活
公开(公告)号：EP2059522A2
公开(公告)日：2009-05-20
申请号：EP07812578.8
申请日：2007-07-03
发明人： RYONO, Dennis E. , CHENG, Peter T.W. , BOLTON, Scott A. , CHEN, Sean S. , SHI, Yan , MENG, Wei , TINO, Joseph A. , ZHANG, Hao , SULSKY, Richard B.
IPC分类号： C07F9/32 , C07F9/40 , A61K31/675 , A61P3/00
CPC分类号： C07F9/6539 , C07F9/582 , C07F9/587 , C07F9/65032 , C07F9/650964 , C07F9/650982 , C07F9/65181
摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure of Formula (I), wherein Formula (II) is a heteroaryl ring; R4 is -(CH2)n-Z-(CH2)m-PO(OR7)(OR8), -(CH2)nZ-(CH2)m-PO(OR7)R9, -(CH2)n-Z-(CH2)m-OPO(OR7)R9, -(CH2)nZ-(CH2)m-OPO(R9)(R10), or -(CH2)nZ-(CH2)m-PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
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